SchafferLab
@SchafferLab
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Joined February 2019
🔥new pre-print from the lab: nicked tRNAs are stable reservoirs of tRNA halves in cells and biofluids. 🧵on why (I think) this is an important study for everyone working on RNA fragments and/or #exRNAs. Spoiler: most RNA fragments... are not! [✂️🧬] https://t.co/1lbIHvSEbc
biorxiv.org
Cells can release ribosomes and full-length tRNAs into the extracellular space, but these species are rapidly processed by extracellular RNases into stable rRNA and tRNA-derived fragments (tDRs)....
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Really beautiful paper from the great Jack Parent @umich 'Self-organizing Single-Rosette Brain Organoids from Human Pluripotent Stem Cells'. Demonstrates a new type of human brain organoid, and models #pcdh19 female-specific epilepsy in a dish.
biorxiv.org
The field of brain organoid research is complicated by morphological variability with multiple neural rosette structures per organoid. We have developed a new human brain organoid technique that...
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We have liftoff! Great overviews of the official launch of the iPSC Neurodegenerative Disease Initiative (iNDI). Large-scale, NIH-funded resource of genetically-engineered isogenic iPSC lines harboring neurodegeneration-related mutations. https://t.co/recqVO9AVl
nia.nih.gov
Researchers can obtain stem cells that NIH Center for Alzheimer’s and Related Dementias (CARD) scientists have specially engineered for studying the genes behind Alzheimer’s disease several other...
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Registration is officially OPEN! We limit the meeting to 300 participants and we typically hit this number. It is in your best interest to register early. Trainees: if you would like to be considered for an oral presentation your abstract must be submitted by Sept 10.
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Happy to share our latest work published in @jbiolchem! We provide the first transcriptome-wide identification of RNA targets for human ADAR3 in glioblastoma cells, which we hope can be a starting ground for understanding this brain-specific RBP (1/4) https://t.co/rMgBcSAxFt
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Excited our study is out! Led by super talent @mariahhoye we discover new mechanisms by which Ddx3x mutations impair brain development and cause @ddx3x syndrome. We profile translation at onset of neurogenesis highlighting importance of RNA regulation 1/. https://t.co/N4mgjVSpOD
elifesciences.org
The RNA helicase DDX3X controls neural progenitor division, cell fate, and translation during embryonic brain development.
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Next week, Dr. @jogleeson_ucsd the Chief Medical Officer of n-Lorem, discusses the role of genetics in neurology, and his optimism for n-Lorem’s future. 🔎 Check here: https://t.co/vKhARyUfZg
#mynanorarestory #nlorem #nanorare #UCSD
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Happy to announce our lab is officially joining the Alzheimer's disease community with new funding support from the @CleveADRC, as well as an ADRD R03 from @NIHAging, to investigate RBPs in disease pathogenesis. Interested graduate students and postdocs, please inquire!
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Looking forward to attending Rustbelt RNA 2022 this year at CCF! Don't miss the opportunity to attend this outstanding event and see Cleveland in the fall 🍂🍂
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A spectrum depends on a spectrum:
Broad Spectrum of Autism Depends on Spectrum of Genetic Factors
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Check out the new awesome preprint from @NuinComm grad student @L_Rylaarsdam in @GuemezGamboaLab about #PACS1syndrome funded by @pacs1foundation and don’t miss the beautiful figures! #ProudPI
I am so excited to share my first @GuemezGamboaLab preprint! Here we investigate disease mechanisms of a #neurodevelopmentaldisorder called #PACS1syndrome. Read on to learn more!
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This is a wonderful program that I'm proud to be a part of, especially b/c it's how I met @DMortonPhD
https://t.co/eM1yc7W9UH
Applications are open for ASHG’s Human Genetics Scholars Initiative! This two-year program works to advance diversity and inclusion in the genetics and genomics workforce. Learn more and apply today.
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Our latest paper on brain mosaicism is online today. Thanks to all our co-authors and other contributors. This was a great collaboration with @shishenyxx, @JSchlache, @genomedan, and @jogleeson_ucsd. You can find it here https://t.co/DgFmvVuRtT .
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New preprint alert‼️ 2 postbacs, 4 years & 26 tandem repeats in the making. Super-postbac @AtagunUlas applies systematic mutagenesis to dissect the mechanism of repeat RNA aggregation, commonly found in neuromuscular diseases. Check out his 🧵👇 @YaleNeuro @YaleRNA @KavliAtYale
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Check out our new preview @NeuroCellPress on an intriguing study by @SchafferLab describing the effect of #CLP1 on mRNA 3' end diversity in #MotorNeuron models of #neurodegeneration. https://t.co/Rh0UnfwX77
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I was so excited to see this Preview by @STOPlabPI yesterday - it really made my day!
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So proud of my first graduate student, Geneva LaForce, who privately defended her thesis the same day her Neuron paper came out!
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