Martin Breuss
@BrEUssMartin
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Assistant Professor in Genetics Interested in genomic mosaicism and neurodevelopment. Opinions are my own.
CU Anschutz
Joined December 2013
#Eukaryogenesis entailed transfer of DNA from #mitochondria to nuclear genomes. @BrEUssMartin re a #PLOSBiology study of #Numtogenesis, extending this process to human somatic cells, correlating with #aging & disease. Primer: https://t.co/OUrC1I7DCN Paper: https://t.co/8s9lZxSgyT
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Ready to connect with industry leaders and propel your career? Don't miss out on this exclusive opportunity! Limited spots are available for discussions with leaders from @saphetor, @MirvieDx, @Regeneron, and @PacBio. Register now for the #ASHG webinar: https://t.co/rIfPQ9I2iX
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1/n Today in @ScienceMagazine: ‘Risk of meningomyelocele mediated by the common 22q11.2 deletion’. https://t.co/FyNib8ynJl
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Our new ms “Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain” is now at @Nature . https://t.co/LNXac5RkFb! We report on human forebrain dynamic assembly during development…1/n
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JOIN US in congratulating Dr. Alicia Guemez-Gamboa on her recent paper on PACS1 Syndrome in Nature Communications. 🎉 Read the publication here: https://t.co/KVtCM581RW
@pacs1foundation seed funding contributed to this work; excited for further collaborations towards a cure!
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Excited to welcome Prof. Naiara Aquizu from @ChildrensPhila @CHOP_Research to @UCSDHealth @UCSDJacobs GBSBC Seminar, speaking on 'Genetic and Epigenetic Mechanisms of Neural Dev. Dis.' Catch it Feb1 12N live or https://t.co/QL5I2tz7x4!
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Latest work from the @JagannathanLab led by our recent PhD🎓Divya @sciliator! Peptidyl-tRNA hydrolysis rate influences the efficiency of nonsense-mediated mRNA decay
biorxiv.org
Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that prevents the accumulation of harmful truncated proteins by degrading transcripts with premature termination codons (PTCs). NMD...
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GCBA Seminar announces Martin Breuss, PhD, Univ. of Colorado Anschutz Medical Campus, Dept. of Pediatrics – Clinical Genetics and Metabolism presenting "Genomic Mosaicism as a Tool to Understand Development and Homeostasis" @BrEUssMartin @UNMC_GCBA @UNMC_BISB In Person Seminar
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We are excited to share our laboratory's recent review on the origin, impact, and utility of genomic mosaicism in the brain in Neuroscience Bulletin ( https://t.co/m8Ye9nDvdg). Authored by Jared Graham in collaboration with @shishenyxx and @JSchlache.
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Check our new ms showing dorsal neocortical origin of inhibitory neurons that disperse radially from origins shared with excitatory neurons. "Cell-type-resolved somatic mosaicism reveals clonal dynamics of the human forebrain". @changukchung @shishenyxx
biorxiv.org
Debate remains around anatomic origins of specific brain cell subtypes and lineage relationships within the human forebrain. Thus, direct observation in the mature human brain is critical for a...
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We would like to send a warm acknowledgment to our resident Boettcher Scholar, Josh Mejia! Josh started in the lab in November 2022 via a Boettcher Collaboration grant. He will be continuing with us through the summer thanks to an additional Boettcher Collaboration grant.
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Check out our latest publication on tendon resident macrophages! In this study, we characterized resident macrophages during murine growth and development and highlighted potential interactions with fibroblasts and the ECM. https://t.co/HXGBgGxkkx
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Thrilled to share our work out on PNAS today! Great thanks to all the families who participated and all our collaborators. Special shot out to the terrific support from Joe @jogleeson_ucsd , and help from @HarryKiv @DavidSeivert in Gleeson Lab.
See our new paper 'TMEM161B modulates radial glial scaffolding in neocortical development'. Awesome job by @ErinLWang, to find cause of human #polymicrogyria (i.e. too many brain folds). co-discoverer @ChrisAWalsh1
https://t.co/k7g5P6cCtk
https://t.co/xJrEkF9bIO.
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Our deep learning-based tool, DeepMosaic, is now out on @NatureBiotech, thanks to Xin for the great work and @jogleeson_ucsd for the wonderful support. Thanks to all our collaborators for their contribution. Hope it will help folks doing mosaic detection! https://t.co/BDq7caAc9v
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Very excited that our newest work by @amberg_nicole @pauler_m and Carmen S @HippenmeyerLab @ISTAustria is out now - congratulations to all - If you want to know how PRC2 regulates cerebral cortex development at the single cell level check it out here
science.org
The genetic state of cellular environment shapes PRC2-mediated neural stem cell behavior in the developing cerebral cortex.
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Live at #2022NDiSTEM our fearless leaders Luuli Tran and @AmyBrig95370525 take the stage to accept our Chapter of the Year Award! They Thank Carlos for being an amazing mentor and @MrsMommyPhD for being our number one supporter!
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Funding success at all levels in our Department through the @NIDCR and MARC U*STAR program. Congratulations to the awardees! @Fantauzzo_Lab @wtforman @lomeli_shull @Artingerlab @NicholsLab
https://t.co/XmtwcM1Gso
news.cuanschutz.edu
Congratulations to Katherine Fantauzzo, PhD, Thomas Forman, Lomeli Shull, PhD, and Julio Jaime on their awards for craniofacial biology research.
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📢We have an opening for a postdoc in my lab! If you are interested in brain organoids and excited about development, evolution, or new technologies, please apply. We have a great record of postdoc success too! https://t.co/0bfNbYFEsF RTs much appreciated ☺️
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Screening sperm for new mutations may help doctors reduce the likelihood of a prospective father passing along a mutation that causes a miscarriage or a congenital disease in their offspring. https://t.co/wm6XqmLG0J great collaboration with @BrEUssMartin in @jogleeson_ucsd lab.
elifesciences.org
Screening sperm for new mutations may help fertility doctors reduce the likelihood of a prospective father passing along a mutation that causes a miscarriage or a congenital disease in their offspr...
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We also found a suggestion that some sperm lineages might be more mutable than others. However, we were underpowered to determine this conclusively. It might be an interesting aspect of what we define as 'Type III' mosaicism though!
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