In the other place you can find me under @stoplab.bsky.social

RT @luijsterburglab: Very proud of this international collaborative team effort defining ERCC1-hepatorenal syndrome as a severe multisystem….

RT @irgarner: Z desperacji mam nadzieję, że zabranie głosu na łamach najważniejszej gazety w Polsce skłoni kogoś do rozpatrzenia mojego wni….

RT @ERC_Research: New ERC report on EU competitiveness!. "It conveyed a shared message that fundamental research is not a luxury.”. ERC Pre….

RT @ula_lobodzinska: Masz 2 minuty, żeby z ramienia @ForumZZ przekonać Ministra Finansów do wyższych podwyżek niż 3% planowe w przyszłym ro….

RT @ItaiYanai: Dear early career scientists! Why not join us in September in Lithuania’s beautiful capital city for the EMBO Young Scientis….

RT @sz_twardoch: Mój dziadek Oskar Twardoch po raz pierwszy powołany do Wehrmachtu został 10 czerwca 1941 roku. Skierowano go na przeszkole….

RT @PhysInHistory: General Relativity for babies ✍️

RT @MasaAShimazoe: Go to the link to see our preprint about linker histone H1!.

I'm particularly grateful to @EMBO @EMBO_YIP and @NCN_PL for funding!.

And finally: The effect of SETD2 on transcription is indirect — it likely acts upstream, modulating a plethora of transcription factors. (5/5).

SETD2’s control of readthrough is independent of alternative polyadenylation. It highlights the importance of distinguishing these two processes: 3’ end processing & termination are not the same❗ (4/5).

In cells that don’t have SETD2 or it’s catalytically inactive, readthrough happens because:.1️⃣ TSS initiation is maintained,.2️⃣ 3’ end cleavage is impaired,.3️⃣ cryptic intragenic transcription gets triggered, especially close to the gene ends. (3/5).

We show that SETD2 activity has pleiotropic effects on protein-coding genes:.🟢 promotes proper transcription initiation for most of them (class I),.🛑 stimulates termination in ~20% — prevents transcriptional readthrough (class II). (2/5).

🚨New preprint from our labs (STOP lab & Nojima lab @pol2rna)! @kopczynska_m and Chihiro Nakayama have been digging into how chromatin remodeller SETD2 controls the start and end of transcription 👇 (1/5)

#EMBLSingleMolecule is starting! Exciting 4 days ahead! @EMBLEvents

RT @TheLancet: 🗨️ “Vaccines have done more to improve public health than any other medical intervention.”. A Viewpoint focuses on cancer va….

RT @tangming2005: 5 papers all computational biologists should read 🧵. 1. A Quick Guide to Organizing Computational Biology Projects.https:….

RT @tangming2005: 8/. Lesson?. Learn the fundamentals first. Use solid packages next. But always double-check the results. Even great too….

RT @ERC_Research: 🚀 Thinking of applying for an ERC grant? We have some great tips for researchers around the world! . The European Researc….

Beautiful!.