Kozo Tomita Lab: RNA Biology
@RnaLaboratory
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Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo Kashiwa, Chiba 277-0882, Japan
Joined December 2021
We are pleased to share our paper "Structures and mechanisms of U6 snRNA m6A modification by METTL16” Nature Communications https://t.co/FTYxDJm3f4
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Pseudouridylation of 7SK by PUS7 regulates Pol II transcription elongation - https://t.co/B11mxOv6Rp
#ScholarAlerts
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Taking part in an RNA epitranscriptomics workshop at EMBL Heidelberg — so inspiring, and great to meet so many amazing researchers on RNA modifications. The fall colors are beautiful.#EMBOEpitrans
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Final nail in the coffin…
🚀Introducing fully automated data processing for repeat-target #cryoEM. Using new tools in #CryoSPARC, it is now possible to obtain resolutions & map quality equal to or better than manual processing, with zero user intervention. Preprint: https://t.co/pt9aRc8p5L
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Here in Nanki-Shirahama for a scientific meeting on RNA. Had a morning walk — perfect weather and so calm.
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Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
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Congratulations to Jun Liu on earning his Ph.D.! He spent six years studying in my lab. Wishing him every success in the next chapter of his journey!
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The flexibility of pseudouridine (Ψ) in base pairing remains unclear. Artificial box H/ACA guide RNAs are engineered for targeted pseudouridinylation which reveals the formation of a high-affinity and functional Ψ–Ψ codon-anticodon pair https://t.co/BMbHQjd4zL
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New online! tRNA as an assembly chaperone for a macromolecular transcription-processing complex https://t.co/15YPdu5qx7
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Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, @csche11h, @sokrypton, @befcorreia and many other amazing lab members and collaborators. https://t.co/PTMoqQqwcU
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[プレスリリース] 正確なmRNAスプライシングを制御するU6 snRNAのm6A修飾の分子機構を解明――スプライシング異常が原因の疾患理解に貢献―――新領域創成科学研究科 https://t.co/EaUsC1ilT4
u-tokyo.ac.jp
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RFdiffusion2 is now live! https://t.co/H5bsYd0YuA You can now design proteins, and in particular enzymes from just partially defined amino acid side chains, and without defining their sequence position or order! Great job @r_krishna3 @woodyahern @dougtischer and everyone else!
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正確なmRNAスプライシングを制御するU6 snRNAのm6A修飾の分子機構を解明 ――スプライシング異常が原因の疾患理解に貢献―― - 東京大学大学院 新領域創成科学研究科
k.u-tokyo.ac.jp
正確なmRNAスプライシングを制御するU6 snRNAのm⁶A機構を解明 ――スプライシング異常が原因の疾患理解に貢献――｜記者発表｜お知らせ｜「学融合」を通じて新しい学問領域の創出を目指す大学院。基盤科学、生命科学、環境学で構成。分野の壁を越えて知の最前線を拓くことを使命とする。
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Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism: Cell
cell.com
Ogawa et al. report that the intrinsically toxic RNA catabolites m6A, m6,6A, and i6A are detoxified through sequential action of ADK and ADAL, forming IMP. Disruption of this modified adenosine...
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The most radically recoded genome yet! Syn57 is E Coli with only 57 codons, freeing space to encode up to 4 non-canonical amino acids. That, combined with its virus resistance, will make it an incredible tool for biomanufacturing. From the Chin Lab in @ScienceMagazine
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🦠 Launching a bimonthly digest on RNA modifications and related topics in bacteria!🤩 First issue: Summer 2025. Shared here + by email, future ones will be quicker reads! 😅 #rnamodifications #bacteria #ribosome Subscribe and share if you are interested!
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Featured on the cover of @ScienceMagazine, BioEmu @MSFTResearch, a deep learning system that rapidly generates diverse protein conformations for accurate insights into protein function. Illustration: N. Burgess/Science; Data: S. Lewis et al., https://t.co/V0fRBX4EXc.
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Seminars by Dr. Dominique Fourmy and Dr. Satoko Yoshizawa (CNRS, ENS Paris-Saclay, Université Paris-Saclay) on new antibiotic susceptibility tests and innovative antimicrobial strategies. Really enjoyed them — fascinating work!
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We are excited to share our latest research on Q-modification in precursor-tRNAs, which just got published in @NatureComms. This was an very exciting and fruitful collaboration with @francescatuorto in Heidelberg. https://t.co/73krcQRqwV
nature.com
Nature Communications - tRNA modifications are essential for function, yet their timing relative to processing is unclear. Here, the authors show that queuosine and derivative modifications occur...
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A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function:
nature.com
Nature Biotechnology - RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.
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