Rohith Krishna Profile
Rohith Krishna

@r_krishna3

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@UWproteindesign

Joined August 2013
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@r_krishna3
Rohith Krishna
3 months
RFdiffusion2 generates new enzyme structures just from the most basic descriptions of their geometry. See @woodyahern's thread to see the next generation of de novo enzyme design:.
@woodyahern
Woody Ahern
3 months
New enzymes can unlock chemistry we never had access to before. Here, we introduce RFdiffusion2 (RFD2), a generative model that makes significant strides in de novo enzyme design. Preprint: Code: coming soon.Animation credit: (1/n)
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@r_krishna3
Rohith Krishna
1 month
Excited to see this out! congrats @DaveJuergens and team :).
@DaveJuergens
David Juergens
1 month
Late, but got it done. Inference and training code for CA RFDiffusion is available here: Please have fun. Getting this online was an adventure, to say the least.
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@r_krishna3
Rohith Krishna
3 months
@woodyahern One of the best parts of science: working with insanely talented colleagues who constantly push the limits of what's possible. Big shoutout to @woodyahern and @json_yim for keeping the standard sky-high.
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@r_krishna3
Rohith Krishna
3 months
RT @json_yim: RFdiffusion => generative binder design. RFdiffusion2 => generative enzyme design. It's rare to find scientists with deep kn….
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@r_krishna3
Rohith Krishna
4 months
Congrats Joe and team!.
@_JosephWatson
Joseph Watson
4 months
I’m excited to share our significantly-updated preprint on de novo antibody design, where we now demonstrate the structurally accurate design of scFvs (in addition to VHHs) with RFdiffusion!
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@r_krishna3
Rohith Krishna
5 months
RT @DaveJuergens: Anna and Sam figured out subtle geometric details of serine hydrolase active sites, and then figured out how make new pro….
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@r_krishna3
Rohith Krishna
8 months
RT @DeepaHRajan: How can a single cell learn without a brain or nervous system? We explore this in my new preprint with @WallaceUcsf! We di….
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@r_krishna3
Rohith Krishna
1 year
RT @yilunliao: 🧵(1/7) Excited to share that our work, EquiformerV2, has been accepted to #ICLR2024. EquiformerV2 is the state-of-the-art on….
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@r_krishna3
Rohith Krishna
1 year
Our work on modeling and designing biomolecular assemblies is now in @ScienceMagazine. RFAA Code: RFdiffusionAA Code:
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@r_krishna3
Rohith Krishna
2 years
RT @SusanaVazTor: 🎉 Excited to share that our paper "De novo design of high-affinity binders of bioactive helical peptides" is officially o….
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@r_krishna3
Rohith Krishna
2 years
RT @ArvindSPillai1: Excited to share a new preprint we just released on the de novo design of allosterically controllable protein assemblie….
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@r_krishna3
Rohith Krishna
2 years
We are planning on releasing code & weights in the coming months (we're super committed to making it available as soon as reasonably possible)!.
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@r_krishna3
Rohith Krishna
2 years
RT @woodyahern: RFdiffusionAA generating a small molecule binding protein against an experimental FXIa inhibitor (OQO), a ligand which is s….
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@r_krishna3
Rohith Krishna
2 years
RT @sokrypton: RoseTTAFold updated to be All-Atom. biological assemblies containing proteins, nucleic acids, small molecules, metals, and….
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@r_krishna3
Rohith Krishna
2 years
RT @json_yim: Sharing an early preprint of my Microsoft AI4Science summer internship project. We developed SE(3) flow matching for protein….
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@r_krishna3
Rohith Krishna
2 years
@woodyahern @PreethamVi @ikalvet This has been an extremely exciting and collaborative project amongst many people at @UWProteinDesign including @jueseph, @woodyahern, @PascalSturmfels and many more at the UW and beyond! n/n.
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@r_krishna3
Rohith Krishna
2 years
@woodyahern @PreethamVi @ikalvet @woodyahern and Felix Morey-Burrows designed and tested binders for bilins, which are molecules involved in photosynthesis. These proteins have different absorbance properties than native proteins and has potential for extending range of wavelengths captured by photosynthesis
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@r_krishna3
Rohith Krishna
2 years
@woodyahern @PreethamVi @ikalvet designed a host of binders to heme with an open substrate pocket that could potentially be converted into enzymes.
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@r_krishna3
Rohith Krishna
2 years
@woodyahern Using RFdiffusionAA, @PreethamVi and Gyu Rie Lee designed binders to digoxigenin, a heart disease drug with diagnostic applications. Their best binder binds tightly and is extremely stable! 6/n
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@r_krishna3
Rohith Krishna
2 years
@woodyahern fine-tuned the structure prediction model to denoise backbones for protein design and created RFdiffusion All-Atom, which shows much better in silico metrics than our previous efforts to design small molecule binding proteins with RFdiffusion. 5/n
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