Vijay Rathinam
@RathinamVA
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Professor of Immunology, UConn Health School of Medicine.
Connecticut, USA
Joined September 2018
Why does RNA undergo glycosylation? Excited to have our new paper out. We in collab w/ Ryan Flynn show N-glycans on glycoRNAs hide self-RNA from endosomal TLRs promoting ‘silent’ clearance of dead cells. @uconnhealth @UConnResearch
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RT @uconnhealth: 📰 IN THE NEWS | "HMN 2025: How Body hides its own RNA from the immune system with sugar" ft. Vijay Rathinam and colleagues….
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RT @beth_psaila: Thrilled that our paper is finally in press @ScienceMagazine!! *Platelets sequester cell free DNA, including free fetal an….
science.org
The cells could be a new source of tumor DNA for liquid biopsies
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RT @R_A_Vishwakarma: N-glycans in a new role and, perhaps, another glyco-checkpoint !N-glycans on glycosylated RNAs hide self-RNA from endo….
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RT @Nature: Nature research paper: RNA N-glycosylation enables immune evasion and homeostatic efferocytosis.
nature.com
Nature - N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal...
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RT @uconnhealth: How does our immune system distinguish our own RNA from that of dangerous invaders? As UConn School of Medicine researcher….
today.uconn.edu
Now that scientists understand the role of RNA glycosylation in deflecting immune system attention, they can check on whether that strategy is somehow going ...
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RT @uconnhealth: 📰IN THE NEWS | "Certain RNA modifications could contribute to the development of autoimmune disorders" ft. UConn Health's….
eurekalert.org
New research published today in Nature from Ryan Flynn, MD, PhD, in collaboration with Vijay Rathinam, DVM, PhD, and his graduate student Vincent Graziano at UConn Health and other colleagues at...
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RT @Lo_Zanzi: #GlycoPower! @RathinamVA.@raflynn5 @VinnieViruses show @Nature that N-glycosylation of host small-RNA at the cell surface pre….
nature.com
Nature - N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal...
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RT @VinnieViruses: Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mech….
nature.com
Nature - N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal...
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RT @LabWaggoner: @RathinamVA @VinnieViruses discovers why RNA undergoes glycosylation: N-glycans on glycoRNAs hide self-RNA from endosomal….
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RT @Kai_Li_IDImmune: Beautiful work to show surface RNA glycosylation (glycoRNA) as an important mechanism for the innate immune system to….
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Sweet Disguise: Body Hides RNA With Sugar ..Thanks to @UConnResearch and @Epitopic for covering our glycoRNA paper! @VinnieViruses.
today.uconn.edu
Now that scientists understand the role of RNA glycosylation in deflecting immune system attention, they can check on whether that strategy is somehow going ...
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Big congrats to Vinnie Graziano @VinnieViruses who led the project and huge thanks to our great collaborators: Jennifer Porat, Thomas Carell, Franck Barrat, Beiyan Zhou @BeiyanZhou_UCHC, Sivapriya Kailasan Vanaja, Michael Wilson, and Penghua Wang @PENGHUAWANG3 !!.
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RT @avi_cmbi: 📢 paper - a new class of RIPK1 inhibitors. Lots of with here, with structure of it bound to RIPK1, biochemistry and more! Was….
pubs.acs.org
Necroptosis is a form of programmed cell death that, when dysregulated, is associated with cancer and inflammatory and neurodegenerative diseases. Here, starting from hits identified from a phenoty...
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Congrats to Sonia Shivcharan, who led the work, & all authors. Thanks to our collaborators Zhichao Fan @zhichaofan, Jianbin Ruan @jianbin_ruan, Noorjahan Panjwani, Neal Alto, and Priya Vanaja 2/2.
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We are excite.d to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network. .@uconnresearch @uconnhealth 1/2.
cell.com
Shivcharan et al. report that endosomal damage sensing by the danger receptor galectin-8 licenses noncanonical inflammasome activation and pyroptosis during intracellular bacterial infections in...
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RT @Kai_Li_IDImmune: We are recruiting at all levels. If you are interested in using cool technologies to study immune recognition in the c….
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RT @Pluchinolab: Honored to be the 2025 Petit Family Visiting Professor in #MS at @uconnhealth! Looking forward to connecting with colleagu….
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