1/2 Another great example of recently discovered “basic” biochemistry is the NOS bond, a new type of covalent bond between lysine and cysteine residues reported in 2021. NOS bonds can exist in solution and there are variants called SONOS (where a K is bound to two C). Awesome!

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, @csche11h, @sokrypton, @befcorreia and many other amazing lab members and collaborators.

What is this marvel of the universe?🤯.

FROM CELL DEATH TO REGENERATION: What if dying cells -come back to life? Now online @embojournal I , we aim to answer this question. Here is the journey. If you🩷science, please dont 🛑till the end of 🧵, I promise you will not regret. 1/n

A new paper in Cell shows that it is possible (simple, really) to convert DNA-editing CRISPR proteins, such as Cas9, into RNA editors. All you have to do is delete a chunk of them. Deleting 55 amino acids from a DNA editor called IscB (the ancestor of Cas9) turned it into a

An Artificial Intelligence Model for Translating Natural Language into Functional de Novo Proteins. 1. A groundbreaking study introduces MP4, a transformer-based AI model that translates plain-language specifications into functional de novo proteins. This approach breaks free

Phage genomes are readily engineered using retron recombineering

Out Now! Microbial chocolatiers of fine flavour #Microbiology #CacaoFermentation #FineChocolate.

A time-lapse film offers a glimpse of a hidden milestone of human development: the moment when the newly formed embryo latches onto the uterine lining. Watch a human embryo implant itself — with brute force.

Greater stomach-brain connection is associated with worse mental health. This is opposite to the belief that being ‘more in tune with your body’ improves mental health.

Is it time to speak bout a "sixth sense" arising in the gut?. Scientists have identified a "neurobiotic sense" that enables the host to adjust its behaviour in response to a molecular pattern from its resident microorganisms. @nature.

A recent survey of nearly 900 postdocs at the Max Planck Society reveals:. 🔹 28% show signs of severe depression.🔹 25% struggle with severe anxiety.🔹 More than half oppose contract caps that force them out after 4–6 years.🔹 International researchers (75% of the cohort) face

Out Now! Aggresomes protect mRNA under stress in Escherichia coli #mRNA #EscherichiaColi #Aggresomes

New OA Resource: "A single-cell, spatial transcriptomic atlas of the Arabidopsis life cycle" An extensive single-nucleus and spatial transcriptomic atlas of the Arabidopsis life cycle that represents 10 developmental time points in 6 diverse organs.

Where are all the de novo designed therapeutics? In a guest post by @frdreyer, we break down what the actual bottlenecks, challenges, and opportunities are in building and deploying purely in silico drug discovery engines, with a focus on antibody structure. Link below 👇

ProteinGenerator simultaneously generates protein sequences and structures using sequence space diffusion

Massively Parallel Free Energy Calculations for In Silico Affinity Maturation of Designed Miniproteins @JCIM_JCTC . 1. Researchers from Temple University have developed a method for in silico affinity maturation of designed miniproteins using massively parallel free energy

🌹Meet #ROSIE, our new AI that predicts spatial multi-protein expression straight from routine H&E images. Built on a large co‑staining dataset (>1k samples, 16M+ cells). It enables cell phenotyping & tissue structure insights w/o extra assays.