BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

🚨 New preprint! Generative modeling comes to cytometry. Meet CytoVI — a deep generative model from the @YosefLab & @IdoAmitLab for antibody-based single-cell technologies (flow, mass cytometry, CITE-seq). https://t.co/Yo0uP140V7 🧵👇

🧵1/8 Happy to share my new preprint “ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer.” I resolved why ID2 is essential for cDC1 lineage specification and uncovered a new paradigm of enhancers. Read here:

Thrilled to share our new paper in @ScienceMagazine ! We identify septal LYVE1⁺ adipose macrophages (sATMs) as niche signals that control stem cell fate, restrain beiging & shape obesity susceptibility. Team effort with @FGinhoux and collaborators. https://t.co/mVWJ451FPQ

Happy to share our latest paper on DC ontogeny! https://t.co/xmz07wMzk3 Congratulations to the team and to Dr Zhaoyuan Liu from the Shanghai Institute of Immunology!

I'm excited to share our new study published in Cell. This work uncovers a critical role for dural mast cells in shaping cerebrospinal fluid flow and protecting the brain from infection.

🧵1/ Excited to share my first publication from the @ColonnaLab in @NatImmunol! We investigated how mutations in the human CSF1R gene disrupt microglia and impair white matter integrity in a rare but devastating neurodegeneration called ALSP. https://t.co/39kxODSumy

Our new study by @DuSiling reveals how CSF1R mutations in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) disrupt glial homeostasis. Key roles for oligodendrocytes, astrocytes & STAT3 signaling. https://t.co/k2PsmXO9mX

Congrats to @KedmiRanit’s group! RORγt⁺ APCs prime food-specific pTregs and induce oral tolerance. Infection or food poisoning temporarily bypasses this, allowing CD8αβ T cell responses to mimicked food antigens without breaking long-term oral tolerance.

Big shoutout to Brown’s group: IRF8-dependent TC are essential for inducing food-specific pTregs & establishing oral tolerance! In line with recent work from Mucida’s, Littman’s, Gardner’s, and our group highlighting the role of RORγt⁺ APC in this process. https://t.co/emADApLMLM

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by @US_FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

Early bird Dendritic cell, Myeloid cell enthusiastic! hurry up Submit your abstract and register soon! poster presentations awards available, amazing talks including: @Idoyaga_Lab @TheColonnaLab @jonykipnis @FGinhoux @KaplanLab @HerbertStr93573 @kodiravi & many others X-less RT

latest from our lab: ITACONATE MECHANISM SOLVED!! Tom Paulenda @tompaulenda solved molecular mechanism of immunoregulatory action of itaconate in macrophages: https://t.co/IymcPTZ7gy Previously, our lab has discovered two major immunoregulatory phenotypes of itaconate in

Super important work from our colleague and friend, Marco Colonna @TheColonnaLab|| Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens: Cell

RORγt+ DCs are key to maintaining intestinal immune balance and preventing inappropriate immune responses to food antigens @TheColonnaLab @CellCellPress @PatFernRod https://t.co/Y7dTy6ZZG0

Excited to share that our work by @PatFernRod and @TongWu99 is published in Cell: RORγt+ DCs are required to induce oral tolerance. Their absence reduces pTregs and impairs oral tolerance to dietary antigens. Read more:

Excited to see this finally out!! We found IL-2 made by CD301b+ DCs critical for the Th2 fate decision of CD4T cells and skewing them away from the Tfh fate. They also seem to use their own CD25 to direct IL-2 to the cognate clone. https://t.co/SA9rxGOLyB

Happy to share our recent work led by postdoc @DanCorral showing that the maternal adapative immune system promotes optimal lactogenesis. https://t.co/XOYnihwLh1

Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control https://t.co/ktqB6ozwp6, in this work we linked autophagy with UPR and ferroptosis in the microglial response to AD @CaiZhangying @TheColonnaLab 🥳🍻🆗

Excited to share that our work is featured on the cover of the latest issue of Cell Host & Microbe! Check it out! @TheColonnaLab @VinoloM @pewtrusts #Microbiology #Immunology #CellHostMicrobe