A tweetorial on our study ( https://t.co/OCqCRJEMdx). But, first a case: Young female w/ a 1.9 cm incidental pancreatic cyst. No concerning features, but KRAS, TP53 and SMAD4 mutations on molecular testing. Surgical resection: #IPMN w/ a small #PancreaticCancer. #Pathology #GIPath

New preprint from @OHSUKnight @SearsRosie @coussens_lisa & colleagues: A window of opportunity trial in metastatic #PancreaticCancer reveals resistance mechanisms to targeting the KRAS-MEK pathway https://t.co/YVvvTK4fse How KRAS and MYC co-amplification lead to resistance.

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Happy to see this published: Blind validation study of PancreaSeq GC across a prospective cohort of 1800+ patients but focused on 241 who underwent surgical resection. Look for our 10,000-patient study soon (along w/ WTS)! #PancreaticCyst #PancreaticCancer https://t.co/3TyFAEZkte

🔥Hot off the press in @Human_Pathology. Study of expression patterns of CLDN18.2 showed high correspondence between primary and matched metastatic PDAC, providing a strong rationale for further exploring anti-CLDN18.2 therapeutic strategies 🔬. @CLuchini10 @gimalleo @SalviaRobi

I'm happy to announce that our work on pancreatic cysts and (possibly diagnostic) glycans has been published online at Cell Reports! All feedback and praise welcome! 1st lab 1st authorship for @KEAnkenbauer

Our medical oncologist, Dr. Vikram Gorantla has 2 posters at #SABCS25 this afternoon in Session5 on real-world treatments for HER-2+ #breastcancer.

The Lustgarten Foundation-AACR Career Development Awards for Pancreatic Cancer Research, in Honor of Ruth Bader Ginsburg and John Robert Lewis, are 3-year, $300,000 grants to support new ideas that advance pancreatic cancer research. Apply by January 6. https://t.co/pyhuPB2tQR

The prognostic role of tumor progression prior to resection of NET hepatic metastases. Analysis of 383 patients undergoing resection of well-differentiated NETLM. Preoperative hepatic tumor progression a strong independent predictor of early mortality following hepatic

I’m pleased to share that registration for the CCF Annual Conference is now open! Join us May 1–3 in Salt Lake City. Patients can apply for a scholarship during the registration process. Don’t miss this chance to connect, learn, and share. Register: https://t.co/f0MgeQOnPc.

FFPE Spatial ATAC-seq is finally possible — and now there’s a simple way to predict whether your tissue will succeed. FFPE blocks are some of the most valuable materials in translational research, but they’ve historically been difficult to use for spatial epigenomic assays. A

Heatmap in ggplot2 https://t.co/Y5jZlq5GYC I always use complexheatmap, but this seems to be a good alternative if you want to stay within the ggplot

I’m thrilled to introduce you to the NeuMap! our latest work in @Nature. A global, comprehensive, single-cell transcriptional atlas of neutrophils across 47 biological conditions in human and mice. A real tour-de-force 🗺️ @AndrsHidalgo16

Case Study Spotlight: Predicting Spatial ATAC-seq Success in FFPE Pancreatic Neuroendocrine Tumor Spatial epigenomic profiling enables high-resolution mapping of enhancer activity and regulatory programs in situ, but FFPE tissue introduces variability in chromatin integrity and

Amazing resource paper in @Cell_Metabolism from @PeteMullen @LyssiotisLab & colleagues! A metabolic atlas of mouse aging https://t.co/5FypcZeknr Metabolic aging across 12 organs and five time points, with cross species validation of depleted hydroxyproline.

COLLECTION of papers on Spatial Transcriptomics of IPMNs (Cystic Precursor lesions of #PancreaticCancer): https://t.co/TAOlsZsc0w https://t.co/lJfrHGxA3G https://t.co/yjTb9Xg1uR https://t.co/ZhobdH0sCF https://t.co/kIRO8rYrm5 https://t.co/Izjv3eTPIx https://t.co/yhgrRbsKIE

Another preprint on spatial transcriptomics in cystic precursor lesions of #PancreaticCancer! Spatial analysis of IPMNs defines a paradoxical KRT17-positive, low-grade epithelial population harboring malignant features https://t.co/Izjv3eTPIx

In @NatureMedicine: @marinabaretti & @MarkYarchoan @hopkinskimmel in an AYA cancer with unmet need: A therapeutic peptide vaccine (FLC-vac) for fibrolamellar hepatocellular carcinoma: a phase 1 trial https://t.co/hv8RsEbA1c 75% DCR, 25% PR, T cell exhaustion 👉🏽 resistance

A wonderful 3rd Annual Pittsburgh GI Cancer Summit. Deeply grateful to our sponsors and to all of our exceptional speakers for making it a success. 😇 @CathyEngMD @KimmieNgMD @smitha42 @PancPathologist @MaenAbdelrahim @DennisJHsu @JanieYZhang @JohnRheeMD @UPMCHillmanCC

Dr. Aatur Singhi (@PancPathologist) outlines how testing pancreatic cyst fluid can help determine a patient’s risk of getting pancreatic cancer.

Final Whipple of the day ✓ On World Pancreatic Cancer Day, grateful for our pathology assistants who bring expertise and care to every case. The work that happens behind the scenes matters. #WorldPancreaticCancerDay #PancreaticCancer @UPMC @UPMCnews

On Genetic Counselor Appreciation Day, Nov. 13, we celebrate Pitt and UPMC’s ocular genetics team. They helped two sisters receive Luxturna, a gene therapy that slows vision loss. https://t.co/pleDabjnqb