Henne_Lab
@HenneLab
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Cell Biology lab at UTSW @UTSWNews. We study lipid droplets and the organization of metabolism in cells.
Dallas, TX
Joined November 2018
Important to celebrate trainee victories: excited to have @HollyMerta's paper out in @CellReports. We use TurboID sub-organelle proteomics to map the ER network. We discover calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility. https://t.co/jTN7j9kmSi
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Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis. Learn more in this week's
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New paper in @ScienceMagazine identifying adipogenin as a critical seipin regulator in LD biogenesis. So glad our lab could help a little in this monumental study. Congrats to all authors! https://t.co/xSmNywS9PW
science.org
The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the...
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Two new Nature papers show that inhibiting FSP1 is sufficient to restrict tumor growth in vivo, a major step forward for ferroptosis-targeted cancer therapy. Huge congrats to all authors! https://t.co/ezDfPzSqvK
https://t.co/uaYWXKoi87
#Ferroptosis #FSP1 #CancerResearch
nature.com
Nature - The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung...
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Excited to share our new study out in @NatureCellBio! Led by postdoc @MikeLangePhD, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. https://t.co/QBM8e07IlC
nature.com
Nature Cell Biology - Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of...
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Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice https://t.co/eZsHUGa5Yq
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We are accepting applications for 2 tenure track faculty positions at UTSW in the Department of Cell Biology! Apply before October 31st!
📢The Department of Cell Biology is hiring! We have two tenure track faculty positions open. See below for more information and how to apply. 🧫🧪🔬 https://t.co/IOLfW6pfco
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Great opportunity for early career faculty!
A terrific new opportunity for new or early career faculty to join the outstanding and rapidly growing faculty of @UTSWBrain. Spread the word!
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In Paris for a science meeting and it was wonderful to spend the day with two friends and scientific heroes, James Olzmann @OlzmannLab and Rachid Thiam @Rachid_Thiam. (Lol, apologies for my hilarious deer-caught-in-headlights pose).
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How do cells sense & respond to lipid imbalances? What happens when a disease-relevant enzyme is blocked? Shiying Huang investigates phosphoinositides with the Balla lab & discovers an integrated cellular response boosting synthesis of alternate lipids! https://t.co/ZhJsQysyhu
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A quick stop in Madrid after the EMBO #LipidDroplets meeting. Madrid is a vibrant city full of energy and flecked with beautiful symbols of the past. Happened to catch a Spanish wedding at the Palacio Mayor.
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Another great EMBO #LipidDroplets workshop in Sant Feliu de Guixols! Many thanks to Maria Bohnert, Robin Klemm, and Bianca Schrul for the wonderful organization!
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Fabulous @EMBO #LipidDroplets workshop in Sant Feliu de Guixols, Costa Brava. A huge thank you to the organizers: Maria Bohnert, Robin Klemm, and Bianca Schrul, for hosting such an inspiring gathering!
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Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations @ShanRhoads and team! 🎉 https://t.co/BPxKlbU6Ou
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New #lipidtime paper out today about a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets https://t.co/tXlbBAK9ur
nature.com
Nature Chemical Biology - An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as...
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New review: Mike Henne (@HenneLab), Emma Reynolds, and William Prinz @UTSWMedCenter discuss recent discoveries and enduring mysteries in the lipid droplet field. https://t.co/A1Qx9ZPzCB
#Biochemistry #CellMetabolism #LipidDroplets
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A pleasure to write this review on lipid droplets for @JCellBiol together with Will Prinz & amazing artist Emma Reynolds! Unlike a typical review, we discuss 5 pervasive mysteries about LDs, and what remains to be discovered about this amazing organelle. https://t.co/FfqQ6pw8eA
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I’m excited to share our latest publication in @PNASNews , revealing a mechanism by which the key regulator CHP1 controls the activity and localisation of lipid-producing enzymes. Huge thanks to the incredible team behind this work! #lipid #PNAS
https://t.co/fBOsFGioHa
pnas.org
The glycerol-3-phosphate (G-3-P) pathway is central to the synthesis of triacylglycerols (TAGs) and glycerophospholipids, essential for membrane bi...
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Excited to share our new review with @DePaceRaffa, @SaikatSls, @cd_w1 @NIH on the BLOC-1 and BORC complexes—key regulators of endolysosomal processes and linked to several genetic diseases #lysosomes #melanosomes #synapses #kinesins
https://t.co/2rrsDwkOJ8
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