
Prashant Bhat
@_prashantbhat
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Uncovering the functions of genome organization | M.D. @UCLAšØš½āāļø| Ph.D. '23 @mitchguttman @Caltech | Previously worked on #CRISPR @doudna_lab @UCBerkeley '14
Pasadena and Los Angeles, CA
Joined November 2017
A long sought after hypothesis has been that organizing biomolecules in and around nuclear bodies is essential for functional RNA processing. We now provide direct evidence of this in @Nature for nuclear speckles and mRNA splicing. Check out this thread!.
What are the functional roles of 3D genome organization? Our paper in @Nature led by @_prashantbhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency.
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RT @brangwynnelab: Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing duā¦.
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RT @yodai_takei: Excited to share our new paper out in @Nature revealing cell-type specific nuclear organization and its link to gene regulā¦.
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RT @mitchguttman: Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paperā¦.
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Hi! Iāll be speaking at @harvardmed Department of Biomedical Informatics on December 5th about genome organization and splicing/speckles. Thank you to the organizers for the invite! Harvard/MIT/affiliate trainees can RSVP to attend with this link:.
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RT @bsabari: I am excited to share our review, published online today @NatRevMCB. Pilong Li, Gaofeng Pei, @Heankel_, and I review the curreā¦.
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Delighted to read this article by @TheScientistLLC featuring our work on nuclear speckles! Also features quotes from @mitchguttman and @belmont_andrew.
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Elegant study by @ejkk0 & @daSpliceIsRight identifying 5'UTR intron sequences that enhance mRNA expression. Cool to see the integ. reporter + higher Dox leading to greater intron-med. enhancement. Suggests a feedback loop between transcription & splicing to boost gene expression!.
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RT @sofiquinodoz: Excited to share a new preprint!.(1)š¬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayeā¦.
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RT @brangwynnelab: How do you turn a condensate inside-out? Congrats to @sofiquinodoz & @jiang_lifei & co-authors on amazing study from ourā¦.
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RT @corcoran_lab: We are really excited to share this story! We discovered that a major function of the KSHV RNA, kaposin, is as an architeā¦.
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RT @UCSF: Cheer on.@UCSFDeptofEMās Kishan Patel, MD, as he competes on @CBS #Survivor47 in the Fiji islands! This ER doctor thrives in highā¦.
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RT @NatRevMCB: Now Online Splicing regulation through biomolecular condensates and membraneless organelles https://ā¦.
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It was fun to present at my first @RNASociety meeting in Edinburgh! Thanks to the organizers for a great meeting and the audience for the engaging questions! #RNA24 . Want to chat about speckles and splicing in different cellular contexts, including disease processes? DM me!
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RT @LaskerFDN: Proximity to nuclear specklesāareas dense in mRNA splicing regulatorsādetermines mRNA splicing efficiency. Variation in distā¦.
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