Peter Ly
@PeterLyLab
Followers
2K
Following
8K
Media
99
Statuses
2K
Genome Integrity Lab | Assistant Professor @CRI_UTSW @UTSWMedCenter. We study how chromosomes segregate, break, and rearrange. @peterlylab.bsky.social
Dallas, TX
Joined October 2018
Our study on the mitotic stopwatch is out. We demonstrate that USP28 interacts with 53BP1 to stabilize p53 and show that cancer cells frequently harbor mutations that impair stopwatch assembly, thereby suppressing the mitotic stress response. https://t.co/p4O1z8dea8
nature.com
Nature Communications - USP28 and 53BP1 proteins form a complex to stabilise the tumour suppressor p53, which is required to protect cells from mitotic stress and subsequent genome instability....
1
7
29
Most honoured and thankful for receiving funding from the @ERC_Research for the #ERCCoG project BrokenChromosomes! We will investigate how scrambled chromosomes in cancer cells arise to drive aggressive disease @embl @emblebi @sangerinstitute @CR_UK
🎉 Congratulations to Isidro Cortés-Ciriano and Wojciech Galej on receiving ERC Consolidator Grants! Both will receive €2M their work on how genome structure and gene regulation shape human disease. Learn more: https://t.co/Pf7DybJyt0
1
2
11
Thrilled to share that my postdoc research is published today in @ScienceMagazine !! We found that DNA repair uses cohesin to build chromatin loops that guide the homology search and boost accurate repair! 1/n https://t.co/DxArg8suv8
science.org
Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop...
5
47
241
latest from the lab --> how we used whole genome passenger somatic mutation patterns 🧬 to trace the origins of never-smoker lung adenocarcinoma (LUAD) to cells of the proximal lung 🫁 @NatureGenet
https://t.co/jqNdVSdZ9z 1/🧵
3
36
105
If you’re interested in aneuploidy, mark your calendar! The FASEB SRC on the Consequences of Aneuploidy will be held Sept 28 - Oct 1, 2026 in Melbourne, Florida. Many speaking slots are reserved for early-career researchers. Please help spread the word! https://t.co/wByEGawYlj
0
4
10
Join us next Tuesday, December 2 at 5pm (Rome) / 11am (NYC) for an exciting GIIN webinar featuring @PeterLyLab and Alessandra Brambati! Zoom link: https://t.co/V7xPTI5wDi Register here to become part of our community: https://t.co/Ys0rufWCIe
0
4
9
Grad students & postdocs, it's time to start thinking about applying to the world famous 'Woods Hole' Embryology course @MBLScience It is a transformative experience. Scholarships available. App Deadline Feb 3, 2026. @SocDevBio
0
27
58
Online now - Transactions on micronuclear DNA and implications for immune signaling
cell.com
Nuclear envelope formations on missegregated chromosomes or chromosome fragments produce micronuclei. Although they exist largely in an autonomous state, they maintain aspects of chromosome biology...
1
9
8
Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute @Cornell
18
89
665
Excited to share our new study uncovering and overcoming the molecular drivers of interspecies PSC competition to improve human chimerism in animals. Big congratulations to first authors Yingying, Hai-xian, and Saku, and to our collaborators!
6
16
62
✅ Attention Undergrads! Are you looking for a summer research program? Explore SURF & the Amgen Scholars Program at @UTSWGradSchool! Gain hands-on experience with leading scientists in your field, develop your skills, expand your network, & more. Applications are now open! 🧫🧬
0
8
9
Thrilled to share our new study "Divergent proteome tolerance against gain and loss of chromosome arms" published in @MolecularCell 🥳🎉 👉 https://t.co/WEYtCv2HMv
#Aneuploidy #Proteomics #Proteinturnover #TeamMassSpec @hupo_org @USHUPO @asmsnews @YaleMed @YalePharm @CancerYale
2
8
21
Megabase-scale loss of heterozygosity provoked by CRISPR-Cas9 DNA double-strand breaks https://t.co/OaCtNpO6Ku
0
19
85
Our paper is out in @Nature! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11 https://t.co/jYAZwj64am
nature.com
Nature - A combination of genome-wide functional screening, imaging and chromatin profiling identifies a new class of highly prevalent genomic elements that help retain extrachromosomal DNA copies...
4
57
251
Our new paper was just out. CRISPR screening with a CENP-C mutant reveals that KIF18A and CENP-E are coordinately involved in chromosome congression. Congrats, Jiahang Miao!! https://t.co/iw2mVVuQa0
cell.com
Miao et al. demonstrate that KIF18A depletion causes synthetic defects with CENP-C hypomorphic mutant and KIF18A functions for chromosome congression in cooperation with CENP-E. CENP-E levels at...
0
9
38
@CRI_UTSW continues pushing the boundaries of science and inspiring the scientific community worldwide! Check out two new publications from the DeBerardinis and @Zhu_Lab labs, published this week in @ScienceMagazine. @UTSWMedCenter @ScienceNews @UTSWScience
1
5
7
Where do cancers start? In the liver, not all cells are the same. The liver is divided into 3 “zones,” and each specializes in different metabolic tasks. We show in @Science that where a mutation occurs in a liver lobule can determine a cell’s fate. https://t.co/3YTc77gZcd (1/9)
23
137
499
Nature research paper: Origins of chromosome instability unveiled by coupled imaging and genomics https://t.co/taO71K0mgF
nature.com
Nature - Coupling live-cell imaging, machine learning and genomic sequencing, the MAGIC platform enables investigation of the cellular context, mutation rates and triggers of spontaneous...
1
39
156
We thank @EviSoutoglou and Ruben van Boxtel for sharing their exciting data with the GIIN community yesterday! Our next webinar is on December 2nd, featuring @PeterLyLab and Alessandra Brambati. Do not miss it! Subscribe here to receive updates: https://t.co/PbZafRcKkp
0
2
6
6 years ago, Lizz took a leap of faith by moving across the country to join our new/empty lab as a research tech. She then became our 1st grad student, playing a big role in shaping our research directions and lab culture. Today she defended her PhD, and I couldn’t be more proud.
Defended! 🍾 Introducing Elizabeth Maurais, Ph.D. 🎉 Congrats on your successful #dissertationdefense. Dr. Maurais was joined by her mentor @PeterLyLab & other Ly Lab mates. Next stop: #postdoc!
0
2
41