Blurton-Jones Lab
@BlurtonJonesLab
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#Neuroimmunology lab @UCIrvine studying the role of #microglia in #Alzheimer’s disease and developing #iPSC-microglia based therapeutic approaches
Irvine, CA
Joined June 2018
It was so much fun working with Sonia, Chris, and the Bennett lab team on this study. Looking forward to seeing all the ways we can apply this new approach to develop microglial-based therapeutics!
Ending 2022 on a high note with the Bennett Lab’s first paper! Excited to finally share this work! TLDR: We (@FChrisBennett and @BlurtonJonesLab) engineered an inhibitor-resistant human CSF1R variant that can be used for microglial replacement. 🧵 below.
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We are excited to share our newest publication from the @BlurtonJonesLab, "Harnessing human iPSC-moceoglia for CNS-wide delivery of disease modifying proteins." https://t.co/5Yb0w1YEt6
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Congratulations to @JPChadarevian and the whole Blurton-Jones team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍
We are excited to share our newest publication from the @BlurtonJonesLab, "Harnessing human iPSC-moceoglia for CNS-wide delivery of disease modifying proteins." https://t.co/5Yb0w1YEt6
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“Chimeric models of breast cancer brain metastases and demyelination” — such an interesting and innovative approach! Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins: Cell Stem Cell
cell.com
Chadarevian et al. show that human iPSC-microglia (iMG) can be engineered ex vivo to enable pathology-responsive and CNS-wide delivery of therapeutic proteins. Their findings suggest that iMG could...
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This amazing news made my week! 🎊 I’m beyond blessed to be part of the @_BrightFocus community while studying the protective microglial responses in the context of Alzheimer’s disease. Super thankful to @BlurtonJonesLab and the entire MBJ team for their continuous support!
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“It is hard to put into words the extent of the damage being done to the US research enterprise, which is of almost incalculable value to both the nation itself and the wider world… An assault on science and scientists anywhere is an assault on science and scientists
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And as my grants are stripped away, I will say thank you so much for protecting me from antisemitism! https://t.co/rz6ZWl7zyQ
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More excellent work from the brilliant @LynnOlst. I’m a very proud PI today. More to come from @ARC_Neuro!
Excited to share our latest @NatureMedicine study from our new center @ARC_Neuro! 🧠✨ Using spatial transcriptomics & scRNA-seq, we uncover how Aβ-targeting immunotherapies shape microglial responses in AD patient brains. A thread with our key findings is below! 🧵(1/15)
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On this #RareDiseaseDay2025 , we cannot remain silent. We must fight on the beach, and on the bench. Call your elected officials, call those who weren't elected who have become our officials. It is not "saving" us money, it is costing us our future. #fightonthebench
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@karchlab we are looking forward to your presentation at #TargetAD25 in Crete next May🇬🇷☀️Registration & Talk Submission is now OPEN so please RT to let your followers know! Find out more: https://t.co/UnjcdFajPX
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Beyond grateful to the Larry L. Hillblom foundation for supporting my postdoctoral research @ucimind big thanks to @BlurtonJonesLab and our amazing lab members for their tremendous help and support with this project!
llhf.org
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So excited to be part of the new VCID Center Without Walls for Understanding and Leveraging Small Vessel Cerebrovascular Disease Mechanisms in ADRD. Looking forward to working with our team @andcyang @JASchneiderMD @BlurtonJonesLab and Yadong Huang @GladstoneInst @rushalzheimers
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We're excited for our latest work published in @Neuron! We explored the impact of Alzheimer's risk factors APOE4 and TREM2-R47H in a tauopathy mouse model, revealing elevated microglial cGAS-STING signaling and senescence in females with both risk factors.
cell.com
Carling et al. combine Alzheimer’s disease (AD) risk factors APOE4 and R47H in a tauopathy model, uncovering amplification of microglial cGAS-STING, interferon, and cGAS-related senescence as...
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Thank you @AlzCanada for promoting the work we recently completed on human CD33 isoforms in Alzheimer’s disease. Beyond grateful for the support to myself and research in @MatthewMacaule4 lab, and super proud to be an ASRP funded fellow. https://t.co/33576C7USl
alzheimer.ca
Dr. Ghazaleh Eskandari-Sedighi from Dr. Matthew Macauley’s group at the University of Alberta talks about her research on elucidating the role of human CD33 protein in Alzheimer's disease pathogene...
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We hope this helps with clinical trial design for people with Down syndrome. Very much enjoyed this productive collaboration!
This research study examines #AlzheimersDisease drug on tissue samples from people with #DownSyndrome. Learn more about this research by co-corresponding author and #UCIMedSchool professor @ElzHead: https://t.co/hQ2QvATdkG
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Important paper on prevalance of CSF1R variants - congrats to David Lynch and colleagues CSF1R-Related Disorder | Neurology Genetics
neurology.org
Background and ObjectivesCSF1R-related disorder (CSF1R-RD) is a devastating neurodegenerative disorder caused by variants in the colony stimulating factor-1 receptor (CSF1R) gene. CSF1R-RD leads to a...
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APOE4-dependent neutrophil-microglia interactions drive cognitive impairment in female individuals with Alzheimer’s disease via IL17F @ButovskyLab, @OlegButovsky, @NetaRose11, @KilianKleemann #neutrophils, #microglia, #IL-17 https://t.co/mH5PoQn3FG
nature.com
Nature Medicine - APOE4-dependent neutrophil–microglia interactions drive cognitive impairment in female carriers with Alzheimer’s disease via IL-17F.
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Another tour de force from @OlegButovsky lab further expanding our understanding of the APOE biology in Alzheimer’s disease. Congrats to the entire team of authors!
Our new work published today @NatrureMedicine
https://t.co/5VMROamUUa… The work led by Neta Rosenzweig (@NetaRose11) and Kilian Kleemann (@KilianKleemann). Thanks to our collaborators @EggenBart, @BlurtonJonesLab, @ReisaSperling @weinerlabhms @NowarskiLab
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We are excited to share new paper led by the talented @NicoleScottHew1 that a microglial C1q, can be internalized by neurons in the healthy aging brain, undergoes liquid-liquid phase separation (LLPS), integrates into neuronal RNPs and impacts neuronal proteostasis 1/3
Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain. @CellCellPress
https://t.co/E7dqyLYoty
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@BlurtonJonesLab @ButovskyLab @NetaRose11 @KilianKleemann @EggenBart @weinerlabhms @NowarskiLab Thanks, Matt! Very excited to continue our collaboration. I hope to see our work on Xe coming soon to light😜
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Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease @NatureMedicine
https://t.co/bjHw0WaLJg
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