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Blurton-Jones Lab Profile
Blurton-Jones Lab

@BlurtonJonesLab

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#Neuroimmunology lab @UCIrvine studying the role of #microglia in #Alzheimer’s disease and developing #iPSC-microglia based therapeutic approaches

Irvine, CA
Joined June 2018
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@BlurtonJonesLab
Blurton-Jones Lab
3 years
It was so much fun working with Sonia, Chris, and the Bennett lab team on this study. Looking forward to seeing all the ways we can apply this new approach to develop microglial-based therapeutics!
@Sonia_Lombroso
Sonia Lombroso
3 years
Ending 2022 on a high note with the Bennett Lab’s first paper! Excited to finally share this work! TLDR: We (@FChrisBennett and @BlurtonJonesLab) engineered an inhibitor-resistant human CSF1R variant that can be used for microglial replacement. 🧵 below.
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@JPChadarevian
Jean Paul Chadarevian
7 months
We are excited to share our newest publication from the @BlurtonJonesLab, "Harnessing human iPSC-moceoglia for CNS-wide delivery of disease modifying proteins." https://t.co/5Yb0w1YEt6
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@GhazalehEsk
Ghazaleh Eskandari-Sedighi
7 months
Congratulations to @JPChadarevian and the whole Blurton-Jones team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍
@JPChadarevian
Jean Paul Chadarevian
7 months
We are excited to share our newest publication from the @BlurtonJonesLab, "Harnessing human iPSC-moceoglia for CNS-wide delivery of disease modifying proteins." https://t.co/5Yb0w1YEt6
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@LabJiang
Peng Jiang Lab
7 months
“Chimeric models of breast cancer brain metastases and demyelination” — such an interesting and innovative approach! Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins: Cell Stem Cell
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cell.com
Chadarevian et al. show that human iPSC-microglia (iMG) can be engineered ex vivo to enable pathology-responsive and CNS-wide delivery of therapeutic proteins. Their findings suggest that iMG could...
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@GhazalehEsk
Ghazaleh Eskandari-Sedighi
7 months
This amazing news made my week! 🎊 I’m beyond blessed to be part of the @_BrightFocus community while studying the protective microglial responses in the context of Alzheimer’s disease. Super thankful to @BlurtonJonesLab and the entire MBJ team for their continuous support!
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@davidrliu
David R. Liu
8 months
“It is hard to put into words the extent of the damage being done to the US research enterprise, which is of almost incalculable value to both the nation itself and the wider world… An assault on science and scientists anywhere is an assault on science and scientists
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@dr_alexharris
Alexander Harris
8 months
And as my grants are stripped away, I will say thank you so much for protecting me from antisemitism! https://t.co/rz6ZWl7zyQ
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@DGateLab
David Gate
8 months
More excellent work from the brilliant @LynnOlst. I’m a very proud PI today. More to come from @ARC_Neuro!
@LynnOlst
Lynn van Olst
8 months
Excited to share our latest @NatureMedicine study from our new center @ARC_Neuro! 🧠✨ Using spatial transcriptomics & scRNA-seq, we uncover how Aβ-targeting immunotherapies shape microglial responses in AD patient brains. A thread with our key findings is below! 🧵(1/15)
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@nachoriko
Mariko Bennett MD PhD (she/her)
9 months
On this #RareDiseaseDay2025 , we cannot remain silent. We must fight on the beach, and on the bench. Call your elected officials, call those who weren't elected who have become our officials. It is not "saving" us money, it is costing us our future. #fightonthebench
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@Fusion_Conf
Fusion Conferences
1 year
@karchlab we are looking forward to your presentation at #TargetAD25 in Crete next May🇬🇷☀️Registration & Talk Submission is now OPEN so please RT to let your followers know! Find out more: https://t.co/UnjcdFajPX
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@GhazalehEsk
Ghazaleh Eskandari-Sedighi
1 year
Beyond grateful to the Larry L. Hillblom foundation for supporting my postdoctoral research ⁦@ucimind⁩ big thanks to ⁦@BlurtonJonesLab⁩ and our amazing lab members for their tremendous help and support with this project!
llhf.org
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@MRIatIIT
MRIIT
1 year
So excited to be part of the new VCID Center Without Walls for Understanding and Leveraging Small Vessel Cerebrovascular Disease Mechanisms in ADRD. Looking forward to working with our team @andcyang @JASchneiderMD @BlurtonJonesLab and Yadong Huang @GladstoneInst @rushalzheimers
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@LiGanLab
Gan Lab
1 year
We're excited for our latest work published in @Neuron! We explored the impact of Alzheimer's risk factors APOE4 and TREM2-R47H in a tauopathy mouse model, revealing elevated microglial cGAS-STING signaling and senescence in females with both risk factors.
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cell.com
Carling et al. combine Alzheimer’s disease (AD) risk factors APOE4 and R47H in a tauopathy model, uncovering amplification of microglial cGAS-STING, interferon, and cGAS-related senescence as...
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@GhazalehEsk
Ghazaleh Eskandari-Sedighi
1 year
Thank you @AlzCanada for promoting the work we recently completed on human CD33 isoforms in Alzheimer’s disease. Beyond grateful for the support to myself and research in @MatthewMacaule4 lab, and super proud to be an ASRP funded fellow. https://t.co/33576C7USl
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alzheimer.ca
Dr. Ghazaleh Eskandari-Sedighi from Dr. Matthew Macauley’s group at the University of Alberta talks about her research on elucidating the role of human CD33 protein in Alzheimer's disease pathogene...
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@ElzHead
Dr. Elizabeth Head
1 year
We hope this helps with clinical trial design for people with Down syndrome. Very much enjoyed this productive collaboration!
@UCIMedSchool
UC Irvine School of Medicine
1 year
This research study examines #AlzheimersDisease drug on tissue samples from people with #DownSyndrome. Learn more about this research by co-corresponding author and #UCIMedSchool professor @ElzHead: https://t.co/hQ2QvATdkG
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@JennOligoMyelin
Jenn Orthmann Murphy
1 year
Important paper on prevalance of CSF1R variants - congrats to David Lynch and colleagues CSF1R-Related Disorder | Neurology Genetics
neurology.org
Background and ObjectivesCSF1R-related disorder (CSF1R-RD) is a devastating neurodegenerative disorder caused by variants in the colony stimulating factor-1 receptor (CSF1R) gene. CSF1R-RD leads to a...
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@GhazalehEsk
Ghazaleh Eskandari-Sedighi
1 year
Another tour de force from @OlegButovsky lab further expanding our understanding of the APOE biology in Alzheimer’s disease. Congrats to the entire team of authors!
@OlegButovsky
Oleg Butovsky
1 year
Our new work published today @NatrureMedicine https://t.co/5VMROamUUa… The work led by Neta Rosenzweig (@NetaRose11) and Kilian Kleemann (@KilianKleemann). Thanks to our collaborators @EggenBart, @BlurtonJonesLab, @ReisaSperling @weinerlabhms @NowarskiLab
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@stevens1lab
beth stevens
1 year
We are  excited   to share new paper led by the talented @NicoleScottHew1 that a microglial C1q, can be  internalized by neurons in the healthy aging brain, undergoes liquid-liquid phase separation (LLPS), integrates into neuronal RNPs and impacts neuronal proteostasis 1/3
@LukensJohnR
John Lukens
1 year
Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain. @CellCellPress https://t.co/E7dqyLYoty
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@OlegButovsky
Oleg Butovsky
1 year
@BlurtonJonesLab @ButovskyLab @NetaRose11 @KilianKleemann @EggenBart @weinerlabhms @NowarskiLab Thanks, Matt! Very excited to continue our collaboration. I hope to see our work on Xe coming soon to light😜
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@LukensJohnR
John Lukens
1 year
Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease @NatureMedicine https://t.co/bjHw0WaLJg
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