Nicholas Sweeney
@NickSweeney23
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Neuroscience | @PennNGG | previously @OSUNeuroscience
Joined October 2024
Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer’s disease:
nature.com
Nature Communications - The role of astrocytes in Alzheimer’s disease pathology remains insufficiently characterized. Here, the authors show that aggravated astrocyte response to Aβ...
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Our glial circadian atlas in AD and aging mice is now out in @NatureNeuro! Congrats to @patwsheehan for incredible work and to our collaborators @johnthefryer, @CarpeRibosomam, @darshan1s, Ron Anafi, and the team. @johnthefryer and I started this in 2019! https://t.co/AYnP0sCbGj
nature.com
Nature Neuroscience - Sheehan et al. have characterized the circadian translatomes of astrocytes and microglia in the mouse cortex in the context of amyloid pathology or aging, revealing cell- and...
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New work from the lab shows that a novel non-coding RNA, FAM151B-DT, is a driver of tau and alpha-synuclein aggregation @washumedicine @RCFNeuro @WashUMedADRC
nature.com
Molecular Psychiatry - A novel lncRNA FAM151B-DT regulates degradation of aggregation prone proteins
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Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice https://t.co/eZsHUGa5Yq
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We are excited to share our latest publication “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" in Acta Neuropathologica this week! Congratulations Zack Augur!! https://t.co/fLoVdSxWoL
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Our RAEFISH spatial transcriptomics technology is now published in Cell @CellCellPress! RAEFISH enables sequencing-free whole genome spatial transcriptomics at single molecule resolution. This work represents the first time that transcripts from more than 23,000 genes were
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'#Autophagic impairment in #sleep–wake circuitry is linked to sleep loss at the early stages of #AlzheimersDisease' Christopher Daniel Morrone, Arielle A. Tsang, W. Haung Yu @UofT @CAMHResearch
https://t.co/NcaF0TNCka
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Multiscale proteomic modeling reveals protein networks driving Alzheimer’s disease pathogenesis: Cell
cell.com
Multiscale proteomic network modeling of Alzheimer's disease integrates large-scale proteomic and genetic data from vulnerable brain regions and reveals key driver proteins such as AHNAK within a...
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In the latest issue! Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications
cell.com
Analysis of the conserved intercellular interactome in human vascular dementia and in a mouse model reveals the Serpine2-Lrp1 and CD39-A3AR signaling axes as potential therapeutic targets.
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Clearing truncated tau protein restores neuronal function and prevents microglia activation in tauopathy mice: Cell Reports
cell.com
Certain tau protein fragments are a characteristic feature of Alzheimer’s disease and other tauopathies and are likely to have a role in disease progression. Antibody-mediated clearance of these...
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Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations @ShanRhoads and team! 🎉 https://t.co/BPxKlbU6Ou
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Targeted degradation of pathologic tau aggregates via AUTOTAC ameliorates tauopathy https://t.co/5fw6mLk1cZ
#biorxiv_neursci
biorxiv.org
The pathogenesis of tauopathies including Alzheimer’s disease (AD) and progressive supranuclear palsy (PSP) involves the misfolding and aggregation of tau. Here, we employed AUTOTAC to induce the...
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Coordination of autophagosome closure and release by the Alzheimer’s disease-associated protein BIN1
cell.com
Autophagy is a pathway that removes damaged or superfluous cellular components. Palmer et al. show that microglial upregulation of BIN1, which is associated with an increased risk of Alzheimer’s...
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Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function
cell.com
Zhang et al. identify TFEB as a molecular link that connects extrinsic neuronal cues to intrinsic oligodendrocyte transcriptional programs. TFEB directly binds to and represses numerous cholesterol...
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ABCA7 variants impact phosphatidylcholine and mitochondria in neurons https://t.co/BYdegedRbW
@Nature
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Ambient Air Pollution and the Severity of Alzheimer Disease Neuropathology
jamanetwork.com
This study examines associations between fine particulate matter air pollution exposure, dementia severity, and dementia-associated neuropathologic change.
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In the latest issue! Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience
cell.com
A single-cell epigenomic and transcriptomic atlas across six brain regions in Alzheimer’s disease reveals widespread epigenomic relaxation and information loss, associated with the selective deplet...
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Astrocytes mobilize a broader repertoire of lysosomal repair mechanisms than neurons | bioRxiv. Exciting work from @madaylab!
biorxiv.org
Lysosomal damage impairs proteostasis and contributes to neurodegenerative diseases, yet cell-type-specific differences in lysosomal repair remain unclear. Using a neuron-astrocyte coculture system,...
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Biomarker-related phospho-tau217 appears in synapses around Aβ plaques prior to tau tangle in cerebral cortex of preclinical Alzheimer’s disease @CellReports
cell.com
Hirota et al. demonstrate that microtubule-associated protein tau phosphorylated at the threonine 217 site (p-tau217), a newly established blood-based biomarker for Alzheimer’s disease, appears at...
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In the latest issue! Senescence-resistant human mesenchymal progenitor cells counter aging in primates
cell.com
Genetically engineered senescence-resistant human mesenchymal progenitor cells can reduce aging markers and improve tissue and cognitive functions in aged macaques, highlighting their potential as a...
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