Jillian Shaw, PhD
@NeuroSciJilly
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Neuroscience Ph.D., Senior Scientific Advisor @broadinstitute; rare disease research; Early Stage Venture Capital Investor at Magnetic Ventures, rock climber.
Cambridge, MA
Joined July 2009
Introducing CHARM: a new epigenome editor to methylate DNA at the promoter of a targeted gene. Our lab's collaboration with @JswLab's @EdwinNNeumann & @TessaBertozzi shows deep silencing of brain PrP Paper: https://t.co/HZRKk2m1b2 Blog: https://t.co/crVVYpyI6w
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If it works in humans, a new epigenome editor could have applications for prion diseases and other neurological disorders like Parkinson’s and Alzheimer’s.
statnews.com
If it works in humans, a new epigenome editor could have applications for prion diseases and other neurological disorders like Parkinson’s and Alzheimer’s.
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Join us on 4/25 from 4-6:30pm for Rock n' Rare in Kendall Square — music & inspiration for the next generation of rare disease rockstars — a family-friendly event with inspiring stories & live music from the rare disease community. Details: https://t.co/zxfuNnOXFc
@broadinstitute
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Internship at the Broad on-site in Cambridge MA! - develop methods to interpret microscopy images - apply deep learning - work at the interface of computer science and biology - ~6 months starting June 2024 - BS/masters/PhD student or recent grad Pls RT! https://t.co/t80Y6gTeCw
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Delighted to introduce PMF-seq: a new way to link genetic perturbations to detailed bioenergetic phenotypes. We use the method to dissect genetics of mitochondrial ETC branching and acute tBID action. Led by https://t.co/jYQkGEVrpg @broadinstitute.
nature.com
Nature Metabolism - The authors report a genetic screening method that preserves mitochondrial physiology under cell permeabilization, which allows in-depth genetic dissection of mitochondrial...
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People with sickle cell disease have new opportunities to eliminate their symptoms, including with a therapy that uses CRISPR gene editing. But the treatments come with obstacles that limit their reach.
nytimes.com
People with the genetic disease have new opportunities to eliminate their symptoms, but the treatments come with obstacles that limit their reach.
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In just a decade #CRISPR genome editing has gone from a new tool to a @US_FDA approved therapy. This approval marks the first of many breakthroughs yet to come in the treatment of human disease; it’s an incredible moment for science and for patients. @VertexPharma @CRISPRTX
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Remarkable to see that our discoveries over 15 years ago would enable such tremendous advances for sickle cell disease and thalassemia!!! Incredible to think that the final sentence of our 2008 paper would be prophetic ( https://t.co/gj069an62b)...
https://t.co/E3ZiSA4ojY
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A truly historic moment, first CRISPR therapy approved! Key ingredients: astute clinical observation on HbF and SS (Janet Watson ca 1948), basic developmental biology, human genetics including GWAS for target ID, and of course CRISPR https://t.co/cLIY2eahDr
gov.uk
Casgevy (exagamglogene autotemcel) is based on the innovative gene-editing tool CRISPR, which won its inventors the Nobel Prize in 2020
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Congratulations @AnnaGreka on the fantastic @TEDTalks! Hear from Anna on "The world's rarest diseases — and how they impact everyone." https://t.co/jlshaACc6H
@GrekaLab
ted.com
Physician-scientist Anna Greka investigates the world's rarest genetic diseases, decoding the secrets of our cells through "molecular detective work." She explains how her team is using new, advanced...
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Awesome preprint from @czbiohub team that builds on #cellxgene to establish a multi-omic annotation workflow. Particularly cool to see how they used the flexibility of the core Annotation tool to include add'l modalities and enable finer annotation.
biorxiv.org
Assigning cell identity to clusters of single cells is an essential step towards extracting biological insights from many genomics datasets. Although annotation workflows for datasets built with a...
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Absolutely over the moon about this Focus issue on the future of bioimage analysis!!! (a short thread)
For this Focus issue, we asked experts in bioimaging from around the world to tell us what excited them about the future of bioimage analysis for the next 5-20 years. (1/n) All Focus content can also be found here: https://t.co/ckMtBOofwv
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Our team is excited to invite you to the inaugural Ladders to Cures Symposium focused on efforts to scale mechanisms-focused research in genetic diseases. This hybrid event is July 18, 2023. Please visit https://t.co/ACmtAMSFvL to register and see the agenda. @broadinstitute
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An honor to host Dr. Arlene Sharpe today for the Units of Life Seminar Series. To join us at 4 pm, please use the link https://t.co/mCjZLWBku4 to learn more about the biology behind PD-1 checkpoint blockade @broadinstitute @GrekaLab
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Window washing daredevils just set up an epic top rope scaling to the roof of the Broad. I wonder if they’d let me take a lap up this “buildering” route? 5.12+ for sure. 🧗♀️
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I will give a brief overview on Cell Painting in drug discovery! Free online webinar and Q&A Weds. May 17th 6 pm CET, noon EST, 9 am PST “Discovering Tomorrow's Drugs: How AI and JUMP-Cell Painting are Shaping Pharmaceutical Advances” Register here: https://t.co/mvB7ab49Mf
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Today we report in @NatureBiotech the development of dual-AAV in vivo delivery systems for prime editors that can support efficient prime editing in multiple organs such as brain, liver, and heart. 1/4
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Congratulations, @AnnaGreka! It was so exciting to see the Greka lab featured on the TED stage. We cannot wait to watch and re-watch the full talk. You're an incredible mentor and scientist!
What an honor to share my work and ideas on the TED red circle at #TED2023 Throughout the TED conference, I kept thinking about one of my favorite quotes from Marie Curie to be "... more curious about ideas" Stay tuned for the release of the talk! Photo: Jason Redmond / TED
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