Edwin Neumann
@EdwinNNeumann
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PhD student @MITdeptofBE in the lab of Jonathan Weissman @Jswlab @WhiteheadInst || BS '19 @UWMadison || he/him || Epigenome editing enthusiast
Cambridge, MA
Joined July 2020
Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in @JswLab with @TessaBertozzi and @ElaineWu0
https://t.co/DrV4EGe92z
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But how is anyone supposed to know where to go? These maps are the sum total of what they put out and they’re total garbage How is a regular person supposed to figure this out?
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We live in an age of (NIH-funded) biomedical miracles Within your lifetime, prion disease was considered potentially impossible to cure. Now there's a promising path towards one https://t.co/HdW6nPrTVS
science.org
Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. However, elimination of endogenous PrP...
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Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in @JswLab with @TessaBertozzi and @ElaineWu0
https://t.co/DrV4EGe92z
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We believe this will forge a path to a much-needed prion disease treatment, and we think CHARM could potentially be applied to other neurodegenerative diseases. Please also check out this excellent perspective piece by @mn_whittaker and @kiranmusunuru! https://t.co/SpzJ8PdWQf
science.org
A new class of editor has improved delivery, durability, tunability, and safety
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Working with @FionaSerack & co. in the lab of prion experts Sonia Vallabh and Eric Minikel @cureffi, along with AAV expert Ben Deverman @DevermanLab & co., we demonstrate that CHARM can potently repress the prion protein throughout the mouse brain.
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.@JswLab and @broadinstitute collaborators have developed a gene-silencing tool that shows promise as a therapy against fatal prion diseases. The tool, called CHARM, paves the way for a new class of genetic approaches to treat certain diseases: https://t.co/5RjeUkx3J1
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Introducing CHARM: a new epigenome editor to methylate DNA at the promoter of a targeted gene. Our lab's collaboration with @JswLab's @EdwinNNeumann & @TessaBertozzi shows deep silencing of brain PrP Paper: https://t.co/HZRKk2m1b2 Blog: https://t.co/crVVYpyI6w
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Excited to share my first paper from grad school out today in @MolecularCell! We systematically define biogenesis pathways for alpha-helical OMM proteins triaged by the NAC and TTC1 chaperone complexes for polytopic and signal-anchored proteins (1/2). https://t.co/UGB8yhKnBW
cell.com
Muthukumar et al. use genome-wide and systematic arrayed CRISPRi screens to identify ⍺-helical OMM protein biogenesis and quality control factors that triage substrates by topology. They establish...
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On @medrxivpreprint today, we describe the plasma & CSF biomarker changes leading up to symptom onset in 4 cohort study participants who went on to develop active prion disease https://t.co/behU25E1IN
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Three of the more costly and frequently used reagents in molecular biology are rolling circle amplification (RCA) mix, chemically competent MachOne (or other E. coli) cells, and Gibson assembly mix. Postdoc Julian Willis—who is starting his own lab in the UK soon—developed
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We are looking for a motivated recent grad (or soon-to-be grad) to join us as a lab technician! A great opportunity to gain research experience for 2-3 years before applying to MD and/or PhD programs. Apply here:
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Thrilled to share my primary PhD work: a Transcription Factor Atlas for understanding gene regulation and cell engineering @CellCellPress. We created a comprehensive TF ORF library and applied it to profile resulting expression changes. A thread 1/X
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Exciting work from my undergrad lab. Coral was an amazing mentor!
Our discovery of changing cell identity by controlling histone modifications in the gene body (not enhancers) at essential housekeeping genes (not lineage specifying factors) is at https://t.co/DwcbJYWlDK 🧵
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Our genome-scale Perturb-seq paper is out today in Cell! https://t.co/ErZZWSJ3VB
@CellCellPress @JswLab Thanks to all the authors and reviewers for their contributions. See the thread below for key findings.
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Excited to share our work using a CRISPR-based lineage tracer to track tumor evolution from a single transformed cell to an aggressive tumor in a genetically engineered KP-Tracer model. It is a great collaboration of the @JswLab, @LabJacks and @YosefLab. https://t.co/at5yMZmtlF
cell.com
Yang et al. developed a genetically engineered mouse model of lung cancer capable of continuous lineage tracing with single-cell RNA-seq readout. They identified the subclonal dynamics of tumors,...
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We are looking for a motivated recent grad to join us as a lab technician! Perfect opportunity to gain more research experience for 2-3 years before applying to MD and/or PhD programs. Follow the link below to apply: 👉
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Excited to share the latest work from my PhD! We performed the first CRISPR activation screen to identify genes that drive solid tumor resistance to T cell-mediated cytotoxicity. A thread 1/X https://t.co/GFZfSw0KnS
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