Mukherjee Lab
@Mukherjee_Lab
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Our lab is using Legionella pneumophila as a tool to gain insights into basic mammalian cell-biological processes. @UCSF
San Francisco, CA
Joined March 2019
A wonderful collaborative effort with Peter Walter @UCSF @stephenfloor @Lan_Wang_ @KroganLab @dlswaney led us to discover that Legionella toxin SidI possesses a tRNA-like shape and glycosylates the translation machinery to induce ribotoxic stress https://t.co/Dnhjeu6vy5
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The link for the faculty position is now posted! Deadline is October 15th. Please share widely with talented scientists in your network. Come join us at UCSF! https://t.co/Gccrtpl8ym
Search: Tenure track Faculty Position @UCSF in the Dept. of Micro and Immuno, with lab space at the Mission Bay campus! We seek a creative investigator with a strong independent research plan who will be a great mentor, colleague, and peer. Job ad soon. Assistant Prof level.
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A surprise gift of « new curve crease origami » we call Lacrygami brought to us by a single cell (this is the first example of origami in a single cell)!! Will write a longer thread shortly describing our journey to discovery - in mean time, enjoy this beautiful cell.
The tiny predator Lacrymaria olor owes its shape-shifting ability to an “origami-like” cellular architecture, a new Science study finds. The results offer a glimpse into geometrical control of behavior in single cells. Learn more in this week's issue: https://t.co/eZq9RMZwKt
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We are excited to report our latest finding that Legionella creates a unique niche that is independent of the host ER network.
Legionella uses host Rab GTPases and BAP31 to create a unique ER niche https://t.co/J0JFJ3roT4
#biorxiv_cellbio
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#FluorescenceFriday #cellbiology #bioart The interior of the cell is a busy place, as seen by grazing incidence structured illumination microscopy at 30 frames per minute: Lysosomes (green) can become corralled by the endoplasmic reticulum (ER, magenta), but can also remodel the
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NEW MBoC Call for Papers: Special Issue on Cell Biology of Infection! Submit an article by Oct 30 to be considered by lead editors: Nihal Altan-Bonnet, @nih_nhlbi
@Mukherjee_Lab, @UCSF Learn more and submit: https://t.co/ygEJuzybC6
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Exciting update! Starting December 2, 2023, all ASCB member submissions to MBoC are ensured a thorough peer review. Simply ensure the corresponding author is an ASCB member to qualify.
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🎁Interested in reading more about the study? Here is the N&Vs article written by Shu-Bing Qian and Saori Uematsu: https://t.co/9YQZovQj4x
https://t.co/0ZhOPikWhT
nature.com
Nature Cell Biology - The bacterial pathogen Legionella pneumophila uses effectors — toxins — to facilitate pathogenesis within host cells. A recent study identifies dual mechanisms of...
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Thank you @NatureCellBio for accepting this work! We are absolutely thrilled!
☕️NEW: @Mukherjee_Lab, Walter & co show that the secreted #Legionella protein SidI is a #tRNA mimic and #glycosyltransferase that inhibits #HostCell translation by inducing #ribosome collisions & #ribotoxic stress response. @UCSF
https://t.co/OtyIFjEMlt
https://t.co/F3JmCg29NM
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Excited to announce that the Department of Microbiology and Immunology @UCSF is seeking candidates for a tenure-track faculty position at the Assistant Professor level. https://t.co/80mTy3aLTG Please RT.
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We are delighted to announce our #ISFS2023 Fellows. Congratulations and welcome to ISFS! We will be highlighting them all through August! To learn more about our fellows visit: https://t.co/Y4qL2iNm8i
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Tenure-track faculty search of the @Ucsf_Biochem Department is open for applications! We are looking for creative, innovative scientists asking fundamental questions in any area of biology. Join our vibrant, collaborative, and supportive community! https://t.co/pPQQFHSEOx
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Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with @ThurstonLab and @CMBI_Szczesna, with @r_lacoursiere driving our side of the project using some amazing tools built by the Geurink lab.
Excited to share our preprint on how a cytosolic bacteria evades LPS ubiquitylation and antibacterial autophagy through an effector with esterase activity. Led by @CMBI_Szczesna in the lab @ImperialInfect @CBRB_Imperial with superb collaborator @jnpruneda
https://t.co/jvXqxWBMFu
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I am happy to propose a model for mammalian #mitochondria UPR signaling, published @Nature. https://t.co/Q1nf0KK2El Mito protein misfolding induces two cytosolic signals –mtROS and mito protein precursor accumulation. These activate the mito UPR via a DNAJA1-HSF1 signaling axis.
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Congratulations to the talented scientists joining our community of Pew scholars and fellows. We are so happy to have you!!!
🎉Congrats to our 2023 biomedical scholars and fellows! These 37 early-career scientists are embarking on innovative research projects in neuroscience, microbiology, cancer research, and more. https://t.co/P4yblIUUNA
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Pleased to describe our latest contribution to the #Legionella world, as we define a clear role for unique phosphoribosyl-ubiquitin transferases in protecting the Legionella-containing vacuole from host driven disintegration. https://t.co/pqxQBY4jcx
biorxiv.org
Legionella pneumophila grows intracellularly within a host membrane-bound vacuole that is formed in response to a bacterial type IV secretion system (T4SS). T4SS translocated Sde proteins promote...
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🚨We're back! Applications for the next #ISFS23 are now open! Postdocs interested in faculty careers: Apply to showcase your work, network w/ hiring institutions, receive mentorship, and connect w scientists from diverse backgrounds! Pls share broadly! https://t.co/IvQoY39cfi
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So well-deserved! Congrats, Kevan!!!
This year’s Sjöberg Prize is awarded to professor Kevan Shokat, @UofCalifornia, for a huge scientific breakthrough that is bringing hope to people who are critically ill with lung cancer. https://t.co/MnATf4BFDg
@UCSFCancer @UCBerkeley @UCSF @kevansf
#Sjöbergprize
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Passionate about both research and #DEI? Applications just opened for this tenure track faculty search across @UCSF basic science departments, in all areas of fundamental biomedical research. Join our vibrant, collaborative, supportive community! https://t.co/IKtipiB0SB
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Tenure-track faculty search of the @Ucsf_Biochem Department is open for applications! We are looking for creative, innovative scientists asking fundamental questions in any area of biology. Join our vibrant, collaborative, and supportive community! https://t.co/9m2ktVXomv
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