Mitochondria & Aging
@MitoAging
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Exploring #mitochondria and #aging. Sharing insights, news, and research on the science of energy and longevity.
Joined October 2012
E-mit is open to all scientists, clinicians, patient associations, companies & other key stakeholders working in mitochondrial research & medicine. Join us & help bring the mitochondrial community together! You can become a member here: https://t.co/zzGfmFXxjc *MT
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E-mit began with 63 founding members from across Europe. We continue to grow as a society & now have 227 members from 26 different countries! We recognize that we are stronger together & are committed to building this community to promote & advance #mitoresearch #MitoAware *MT
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Today 2-3PM E-mit we will be taking over @MitoResearch page to share our mission to promote and develop scientific research in Mitochondrial Biology and Disease and empower a new generation of scientists. Tune in to learn more! #WorldMitoWeek #MitoAware #Mito
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Mitochondrial dysfunction is a central hallmark of aging and energy transduction is a promising target for longevity interventions. New research suggests that interventions in how energy is transduced could benefit healthy longevity.
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Online now! Check out our latest review on the many and varied ways cells rid themselves of their damaged or unwanted mitochondria. Mitochondrial Degradation: Mitophagy and Beyond https://t.co/WyzwcrM0yF
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Dear E-mit members, this is a reminder for the Junior member representatives (one PhD student/Postdoc and one trainee clinician) nominations! The deadline for the applications is July 20th, 11 am CEST. Further information can be found on https://t.co/hdl7KWrZ3D
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I am happy to propose a model for mammalian #mitochondria UPR signaling, published @Nature. https://t.co/Q1nf0KK2El Mito protein misfolding induces two cytosolic signals –mtROS and mito protein precursor accumulation. These activate the mito UPR via a DNAJA1-HSF1 signaling axis.
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We show that optogenetically increasing #mitochondrial membrane potential during adulthood using a #light-activated proton pump improves age-associated phenotypes and extends #lifespan in Caenorhabditis elegans. 👇 https://t.co/9PSQjtaZgs
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A true surprise to find astrocyte primary cilia affected in mitochondrial brain disease. Big congrats for revealing new biology @ignatenkolesya, master mind behind the findings & @SatuMalinen_ @GulayseDunn et al. Now out in @JCellBiol. @HelsinkiUniMed @helsinkiuni @STEMMProgram
Mitochondrial dysfunction induces motile ciliogenesis program in astrocytes! 😯 New study in @JCellBiol by @ignatenkolesya @GulayseDunn @AWartiovaara from @ASW_lab and colleagues @helsinkiuni @STEMMProgram: https://t.co/ljMoyHg4F0
#CellMetabolism #Disease #CellSignaling
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Great collection of mitochondrial papers are available in the latest issue of @Cell_Metabolism including a cool cover art! Looking forward to reading them all!
#NewIssue ft. Cover Art by @sahola6 depicting different mitochondrial morphologies in disease 👩🔬 🔗 the exciting paper that inspired the art: https://t.co/KSVeSr9GZS
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Great work by @Erikafvb and Cristina Ugalde!
New! Online now: Two independent respiratory chains adapt OXPHOS performance to glycolytic switch
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Exciting new study on ISR from @langer_lab, just presented on #Myology2022 #MitoNice2022 Congrats to @sahola6
New! Online now: OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy
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🚨Final call for abstracts and registration for Problems in the Powerhouse: Mitochondrial Dysfunction in Cancer - 24th/25th🚨 Fantastic programme of invited speakers, short talk and poster slots available - don't miss out! https://t.co/rLaxjsufbG
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Double administration of self-complementary AAV9NDUFS4 prevents Leigh disease in Ndufs4−/− mice
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The mitochondrial genome is detectable in practically every human biofluid, mostly found inside small vesicles or as whole mitochondria. @CarolineTrumpff and Shannon Rausser found that cell-free mitochondrial DNA (cf-mtDNA) also is detectable in human saliva.
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Delighted to share the first tweet from the @Mito_Redox lab @NatMetabolism @Cambridge_Uni @MRC_MBU Check out this important guideline for those interested in studying redox biology. DR. ⬇️⬇️ https://t.co/bQZr6pkZxU
nature.com
Nature Metabolism - Reactive oxygen species (ROS) have important roles in health and disease, but are chemically complex and difficult to measure accurately. This consensus statement proposes...
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New study in @Nature by Joanna Rorbach and Anas Khawaya @MolMet_KI visualizes in detail the machinery that the cells’ powerhouses, the #mitochondria, use to form their proteins. Collaboration with researchers at @Stockholm_Uni. #ribosomes
https://t.co/ltCxvvuS4a
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ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1 | Nature Communications
nature.com
Nature Communications - The authors showed that, in C. elegans, inhibition of translation or mTORC1 increases ATF-4 expression independently of ISR signalling. ATF-4 promotes longevity by...
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