Matteo Fiorenza
@Matteo_Fiorenza
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Assistant Professor @CTMetabUCPH & @CNMC_RH | #Physiology #Metabolism #Mitochondria #Diabetes #Obesity #Exercise #Muscle
Copenaghen, Denmark
Joined April 2018
Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans. New paper out today in @ScienceAdvances. 1/10 🧵👇.
science.org
Selective targeting of mitochondrial oxidative stress mitigates lipid-induced insulin resistance in humans.
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RT @proferikrichter: Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs.A Comprehensive View of Muscle….
journals.physiology.org
Skeletal muscle is the main site of glucose deposition in the body during meals and the major glucose utilizer during physical activity. Although in both instances the supply of glucose from the...
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RT @tejensen23: Our new paper in Redox Biol showing that insulin stimulation of skeletal muscle surprisingly does not detectably increase t….
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RT @DanielJDrucker: Here it is proposed that halofuginone, a FDA–approved anti-scleroderma and antiprotozoal drug, is a promising anti-#ob….
science.org
Halofuginone curbs weight gain in mice and pigs.
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RT @vonmeyenn_lab: New in @Nature🧬: We discovered why keeping weight off is so challenging - fat cells retain an epigenetic #memory of thei….
nature.com
Nature - Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially...
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RT @KatsuFunai: New preprint! We show that GLP1RA semaglutide increases skeletal muscle OXPHOS efficiency in mice. Improved energy efficien….
biorxiv.org
Objective Glucagon-like peptide 1 receptor agonists (e.g. semaglutide) potently induce weight loss and thereby reducing obesity-related complications. However, weight regain occurs when treatment is...
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RT @Z_GerhartHines: Our new paper, "NK2R control of energy expenditure and feeding to treat metabolic diseases," is out today in @Nature. H….
nature.com
Nature - In mouse and nonhuman primate models, treatment with selective, long-acting neurokinin 2 receptor agonists aids weight loss by suppressing appetite and increasing energy expenditure, as...
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RT @TheLancetEndo: Managing #insulin resistance: the forgotten pathophysiological component of type 2 #diabetes #T….
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RT @DanielJDrucker: Translational and mechanistic evidence implicating mitochondrial oxidants in the development of lipid-induced muscle #i….
science.org
Selective targeting of mitochondrial oxidative stress mitigates lipid-induced insulin resistance in humans.
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10/ My research on the role of #mitochondria in human #diabetes & #obesity continues at @CNMC_RH @Rigshospitalet & @BiomedUCPH @UCPH_health. Looking forward to sharing new findings from ongoing physiological studies in individuals with genetic mitochondrial defects.
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9/ This study culminates my research work at the August Krogh Section for Human Physiology @NEXSKU.Thanks to the editor, reviewers, and co-authors @JohanOnslev @MuscleBiology @kasparwp @tejensen23 @morten_hostrup.Grateful to @novonordiskfond & @koebenhavns_uni for the support.
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8/ Last, through ex vivo studies in human skeletal muscle fibers, we show that selective targeting of mitochondrial redox state by mtAO partly rescues lipid-induced impairments in mitochondrial bioenergetics.
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7/ Through complementary in vitro studies in collaboration with @MolecularUCPH, we confirm that disrupted GLUT4 trafficking is a key molecular mechanism by which mitochondrial oxidants impair muscle insulin action.
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6/ …ii) reduced mitochondrial oxidative burden in skeletal muscle under lipid overload.
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5/ Mechanistically, the insulin-sensitizing effect of mtAO was linked to i) augmented insulin-stimulated GLUT4 translocation and…
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4/ Through insulin clamp studies combining infusion of a lipid overload with intake of a mitochondria-targeted antioxidant (mtAO), we show that selective modulation of mitochondrial redox state enhances insulin-stimulated muscle glucose uptake during lipid oversupply.
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3/ Inspired by preclinical work by @DPhaz @davidjamesoz & others.we employed an in vivo mechanistic approach to interrogate whether the causal link between mitochondrial oxidative stress and insulin resistance translates to humans.
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2/ In this human physiological study, we show that mitochondrial oxidants are implicated in lipid-induced muscle insulin resistance, underscoring the potential of mitochondrial redox-targeted interventions to improve insulin sensitivity in hyperlipidemic states such as obesity.
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RT @mackinprof: Muscle matters: the effects of medically induced weight loss on skeletal muscle
thelancet.com
The importance of skeletal muscle mass is increasingly being recognised in the medical field.1 The crucial roles of skeletal muscle have come to the forefront of public attention due to data on the...
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RT @CellRepMed: Online now: Weight-loss maintenance is accompanied by interconnected alterations in circulating FGF21-adiponectin-leptin an….
cell.com
Fiorenza et al. reveal selective and dynamic alterations in energy-balance-regulating metabokines and sphingolipids throughout weight loss, weight-loss maintenance, and weight regain in adults with...
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