david james
@davidjamesoz
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science surf and sun. father brother husband. we need more systems biology tighter data and diversification
Sydney, New South Wales
Joined April 2019
We have an exciting postdoc opportunity at the interface of metabolism and epigenetics! 🔥🧬 The project will investigate novel metabolic factors driving diabetic cardiomyopathy🫀, and test targeted dietary interventions 🍽️ For more detail and to apply: https://t.co/IKMJmMAQMo
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Newest insight in exercise effects on muscle insulin action in men with normal and decreased insulin sensitivity.
New! Online now: Personalized phosphoproteomics of skeletal muscle insulin resistance and exercise links MINDY1 to insulin action https://t.co/eKJN94ht3N
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Ozempic Wave: our panel discusses the implications of living with #obesity - the underlying genetics, stigma, and the long-term health implications. What of the drugs (pharmacotherapy)? David James Samantha Hocking Andrew Wilson Louise Baur Giles Yeo #ozempic #semaglutide
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Amazing to finish the year in this way! Our paper is out. We observed that mitochondrial ceramide induces ETC and coenzyme Q depletion driving insulin resistance in muscle @eLife 🥳🔬🥼 #mitochondria @jimmib_78 @davidjamesoz
elifesciences.org
In vitro and in vivo studies uncovered a molecular link between elevated mitochondrial ceramide levels, coenzyme Q depletion, and insulin resistance.
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I don’t normally like to use this platform for politics but today Australia voted ‘no’ to support our aboriginal people. I am saddened today for them and all they have done. All Australians should be ashamed today
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Join us today in congratulating the seven winners and seven runners-up of this year’s Ben Barres Spotlight Awards! 🎉 Learn all about them and their work here 👇 https://t.co/i0PxnAf8kJ
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“I’ve only just played a small role like other Aboriginal leaders do... the answer lies with the mass of Aboriginal people, not with the individuals” Dr Charles Perkins We fully & unequivocally support the Aboriginal and Torres Strait Islander Voice ➡️ https://t.co/EaqB3Kip7S
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Check out our latest efforts to bring together insulin signaling and genetics, https://t.co/W7vINb2q5Q featured here https://t.co/EcR0JiwyKK by @elife Another team effort from @CPC_usyd @JulianvanGerwen @SeanJHumphrey @MassonStewart
elifesciences.org
An analysis of insulin-controlled proteins in the skeletal muscle of genetically distinct mice sheds light on the interplay between genes and diet in type 2 diabetes.
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We have an exciting postdoc opportunity @Sydney_Uni to study molecular control of insulin sensitivity. Plz visit our homepage if interested
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Great to see this published- very proud to have contributed to this study. Congrats to Alice and thanks to all collaborators. Very excited to find out more about these novel genes that regulate Glut4 responses
Delighted to see our work on post-prandial insulin resistance published https://t.co/wdnitqiAeO Its the result of a great collaboration with, among others, #ClaudiaLangenberg @omicscience, @DPhaz @KLMohlke, #EleanorWheeler and #NickWareham
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Excited to share our preprint: "Leveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance" with @davidjamesoz @JackyStoeckli @adiazvegas and many others! https://t.co/Jnfk9KnldJ
biorxiv.org
Systems genetics has begun to tackle the complexity of insulin resistance by capitalising on computational advances to study high-diversity populations. “Diversity Outbred in Australia (DOz)” is a...
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Such a privilege bringing this project to life with @DPhaz, @SeanJHumphrey, @davidjamesoz, and many more! We used phosphoproteomics to explore signalling rewiring in adipocyte insulin resistance. Out now in @NatureComms
https://t.co/NsYXOK1V68 More in our🧵
Our Adipocyte Insulin Resistance Phosphoproteome is out in @NatureComms! #signalling #metabolism
https://t.co/phh9XBsfew A thread🧵…
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Deep proteome profiling of white adipose tissue reveals marked conservation and distinct features between different anatomical depots https://t.co/FUABZX6xfZ. Congrats to Soren an awesome Danish postdoc in my lab and his friends for getting this across the line.
mcponline.org
In BriefMadsen et. al measured deep proteomes of visceral and subcutaneous adipose tissue and isolated adipocytes in a lean and obesogenic state. In the lean state, the adipocyte proteomes from...
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Thanks to all coauthors for their important contributions! Very happy to see this work out now. With @TimoMueller_IDO, @NatalieKrahmer, Oliver Plettenburg, Marta Miaczynska, Christian Behrends, Michael Roden, Matthias Blüher, Jürgen Okun, Stephan Herzig & the entire @ZeigererLab
Can we alter glucagon receptor signaling outcomes by changing it’s localization within the cell? Yes, we can! Let me explain how (and why that matters). (1/7) @RevathiSekar14 @kmotzler @helmholtz_diabc @HelmholtzMunich @Cell_Metabolism @CellPressNews
https://t.co/TjQspg4zSo
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If you are interested in fat cells this might be vey useful. Great effort Soren and Marin.
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Check out the line up invited speakers of stellar symposia at #AuPS2022
Registrations and abstract submissions to #AuPS2022 are now open! Be sure join us share your, and discuss the latest, developments in #physiology at what is set to to be an excellent meeting!
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Interested in healthy ageing? Looking for a motivated postdoc with experience in proteomics. Collaboration between James and @mark_larance labs @cpc_usyd. Please apply to David.james@sydney.edu.au
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We're pleased to start inviting submissions to a new Special Issue: Allosteric Regulation of Kinase Activity. Read the call for papers and find out how to submit your work today: https://t.co/AQf9EIdNGd
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