Ever wondered if nuclear pore architecture and function changes during germ cell differentiation? In human spermatogenesis it does, and radically!! Check out our first lab preprint @AliaCSantos et al! https://t.co/WU3bWNAzWI @PiotrKolata1 @AlisterBurt @TDendooven @MRC_LMB

🎉 Finally out! 🎉 Thrilled to share our work on the evolution, structure and membrane remodeling of Asgard ESCRT-III proteins! Congrats to all of our wonderful authors and collaborators 😍

🚨 New article alert! 🚨 I wrote an article in @Nature about how anyone in a well-resourced lab can implement to democratise scientific resources and training worldwide. 🌍🧪 👉 https://t.co/3fvcoKoi61 @Cambridge_Uni @MedCambridge @CaiusCollege @MRC_LMB

Soon bye bye Xtwitter!

I have two job adverts open at the minute: - A PhD position on fast MLIPs for biomolecules ( https://t.co/06TAnh6kF2) - A postdoc position on developing a universal molecular mechanics force field ( https://t.co/VxvVfUbjiT) Feel free to get in touch with questions.

@AdrianoAguzzi How about adding something like this to the author contribution section ? "The authors agree that equally contributing authors appear in a random order and may swap their order. The 'equal contribution' designation shall remain intact and will not be removed."

@biorxiv_cellbio @biorxivpreprint

This fascinating journey through sperm cell differentiation would not have been possible without the great collaboration with David Barford lab, @TomHale1040915, EM facility @gcannonii, and LM facility! Enjoy the read!!

After meiosis nuclear pore architecture changes drastically resulting in a reduced scaffold with only the inner ring present. We find that the pore’s central channel is highly constricted, slowing down nuclear diffusion, and that Ran dependent transport is severely perturbed!

Thanks to @royalsociety and @MRC_LMB, @lab_baum and I are looking for a student to develop the next generation of fluorescent proteins for live and super-resolution imaging, as part of the LMB's four-year PhD programme. https://t.co/HcbNL5hRrQ

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Thank you everyone for everything peripheral: Lamins, LADs, NPCs, LINC comp, laminopathies, peripheral chromatin et al! Great 10th NECO meeting @Bruneluni @Co_Biologists @BiochemSoc @abcam @Nufediaz @PaolaVagnarelli @Frances91557638 @adambyron @MatteoAll @mankie06 @CenGEM_Brunel

Check out JP’s virtual lift-out experiment that made it on the cover of Nature Methods!

Come and join this amazing group of scientists to work at the cutting edge of structural biology of telomeric complexes. The LMB is a highly collaborative place. Please share!

Over the moon about this work! 🤩 Sam @Samlacey combines cryo-EM, #teamtomo magic, #AlphaFold, and structural proteomics (with Andrea Graziadei) to reveal the molecular structure of retrograde IFT. Massive breakthrough by an incredible talented young scientist. Bravo Sam! 👍 🚂

Join our fantastic EM facility team!All latest high end instrumentation available!