Buzz Baum's Lab
@lab_baum
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We are a cell biology lab studying cell morphogenesis at @LMCB_UCL @ucl & @MRC_LMB @CellBiol_MRCLMB. Tweets by lab members
Joined July 2020
🎉 Finally out! 🎉 Thrilled to share our work on the evolution, structure and membrane remodeling of Asgard ESCRT-III proteins! Congrats to all of our wonderful authors and collaborators 😍
Happy to share the final format of our paper on Asgard ESCRT-III and the evolution of this protein family in eukaryotes! https://t.co/tewd24Of0m
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Very cool! ESCRT-III is the PDB "molecule of the month"!
pdb101.rcsb.org
ESCRT-III forms helical assemblies that remodel cellular membranes
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Thrilled to share our latest work @RouxLab @lab_baum with @diorge_souza and @sami_chaaban ! Phylogeny, structure, and function of ESCRT-III proteins in Asgard archaea, the closest relatives to eukaryotes. Big thanks to @ERR_Moody, Tomo Hating, @SPOREMOHAN @tweethinking !!
We're thrilled to share our new preprint: "Evolutionarily Conserved Principles of ESCRT-III-Mediated Membrane Remodeling Revealed by a Two-Subunit Asgard Archaeal System." https://t.co/1SboXsSj81
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Excited to unveil our productive collaboration @lab_baum @RouxLab, featuring 3 co-first authors @diorge_souza, @jespadas91, and @sami_chaaban! Special thanks to @ERR_Moody, Tomo Hatano, and @SPOREMOHAN @tweethinking for their invaluable contributions!
We're thrilled to share our new preprint: "Evolutionarily Conserved Principles of ESCRT-III-Mediated Membrane Remodeling Revealed by a Two-Subunit Asgard Archaeal System." https://t.co/1SboXsSj81
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We're thrilled to share our new preprint: "Evolutionarily Conserved Principles of ESCRT-III-Mediated Membrane Remodeling Revealed by a Two-Subunit Asgard Archaeal System." https://t.co/1SboXsSj81
biorxiv.org
ESCRT-III proteins assemble into composite polymers that undergo stepwise changes in composition and structure to deform membranes across the tree of life. Here, using a phylogenetic analysis we...
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It’s out! We use internal tags to illuminate SARS-CoV-2 Envelope (E), report its interactome by BioID, find viral sequences and cellular factors controlling ER-export and Golgi-to-lysosome traffic and show E deacidifys lysosomes to aid viral replication.
science.org
SARS-CoV-2 Envelope exploits host cell endomembrane trafficking pathways to deacidify lysosomes and enhance viral replication.
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Explore the hypothesis by @BaumBuzz @anjspa1 on the origin of the eukaryotic nucleus! Unraveling the intertwined history of archaea and eukaryotes, their study proposes a compelling model for the nucleus' ancient roots! @MRC_LMB @NIOZnieuws
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Thrilled to share the publication of this review by @JezCarlton and @BaumBuzz "Roles of ESCRT-III polymers in cell division across the tree of life" 😍🥳🥹
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Ever lain awake at night wondering which fluorescent dyes can be used to label cells in near-boiling acid? Look no further than our most recent paper in @lab_baum on what worked and what didn't for live cell imaging of a hyperthermophilic archaeon:
frontiersin.org
Archaea are key players in many critical ecological processes. In comparison to eukaryotes and bacteria, however, our understanding of both the cell biology ...
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Better late than never! Great work from our fly girls @GCazzagon @Roubinet31 , describing that SCAR and Arp2/3 regulate apical cortical remodelling in asymmetric stem cell divisions. Congrats and all the best in your future endeavours! 🥳🪰 https://t.co/r5hP8SrDom
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@helenkmatthews @CurrentBiology @lab_baum @LMCB_UCL @MCB_Sheffield @TUOS_Cancer @ScienceShef My first ever tweet is dedicated to the amazing team @lab_baum @helenkmatthews @uclcancer that I was lucky enough to work with during my PhD and this paper- delighted to see it in print in @CurrentBiology
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@helenkmatthews @CurrentBiology @lab_baum @LMCB_UCL @MCB_Sheffield @TUOS_Cancer @ScienceShef It’s been a long journey. Fabulous to see the last chapter in the @helenkmatthews @lab_baum collaboration on cancer cell divisions out in the world. Beautiful work Sushila. Thanks Tom Agata & Rachel for your amazing contributions. An especial thanks to Tim for making it possible!
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Proud of this great work led by @helenkmatthews, Sushila Ganguli and a talented team! Check out the thread below 👇"Oncogenic Ras deregulates cell-substrate interactions during mitotic rounding and respreading to alter cell division orientation"
cell.com
Cell division is dysregulated in cancer. Ganguli et al. show that activation of an oncogene, Ras, directly alters cell-substrate adhesion and cell shape during progression through mitosis. These...
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My friend Helen needs help. Please take a moment to check out my GoFundMe campaign: https://t.co/CmI6M03OyK Thank you so much for your kindness and support. Buzz
gofundme.com
My name is Buzz. I am a biomedical researcher. I am fundraising for a fri… Buzz Baum needs your support for Helen has cancer - she shouldn't be made homeless
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Yesterday, @BaumBuzz gave a fascinating and inspiring talk on the archaeal origins of eukaryotes🤩. Thanks to our PhD-led Cell Biology Seminar Series for inviting Buzz here to the @biozentrum. Buzz, next time we’ll meet for a Negroni on Planet C 🍸 🪐
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NEW #LMBpublications Dynamics of cell rounding during detachment https://t.co/gFxFKymESZ
pubmed.ncbi.nlm.nih.gov
Animal cells undergo repeated shape changes, for example by rounding up and respreading as they divide. Cell rounding can be also observed in interphase cells, for example when cancer cells switch...
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Discover the secrets of cell rounding during detachment of interphase cells in our latest article! Our study uncovers the role of actomyosin-dependent cortical remodeling and ERM activation in driving this process. Interesting reading for anyone studying cell mechanics!
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