Piotr Kolata
@PiotrKolata1
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Postdoc at @MRC_LMB @MatteoAll group. Studying #nuclearenvelope across scales #teamtomo and team #cryoEM ❄️🔬 previously @VIBLifeSciences, @RouslanEfremov group
Brussels
Joined December 2019
Our work with @RouslanEfremov on the #cryoEM structure of E. coli respiratory complex I in #nanodiscs is in @eLife! https://t.co/5GMw5RHPwJ 🥳🔬❄️ Thank you @ERC_Research @structbiolbxl @BECM_VIB @VUBrussel & all my colleagues for all the support, what a journey!🎢 A thread:[1/6]
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Science has become obsessed with publishing numbers. With this new satirical proposal, have we reached peak metric? https://t.co/LlS6dywj1M
nature.com
Nature - Science has become obsessed with publishing numbers. With this new satirical proposal, have we reached peak metric?
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EU Food Science Authority Condemns Bad Microplastic Studies: EFSA shows how most microplastic studies were deficient, unreliable and corrupted. 13/ https://t.co/vXFwJr82B9
thefirebreak.org
EFSA shows how most microplastic studies were deficient, unreliable and corrupted
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Last year in @SciRobotics, researchers followed up on their development of Third Thumb—a robotic appendage that, when trialed by members of the general public, was a big hit. Learn more: https://t.co/46Uayg5Qy1
#ScienceMagArchives
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New preprint from @DuXDaniel @FitzpatrickLab shows #femtosecond light pulses can lens electron beams, promising higher contrast in #cryoET and better aberration correction in #cryoEM
https://t.co/Ve5rDLTg4A Experiments made possible by support from @cziscience #ImagingTheFuture
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Time‑resolved cryo‑EM now films proteins every 5µs: ⚡️Lasers melt‑revitrify + 💧droplet mix‑and‑spray chips need just 100nL per shot, catching fleeting drug‑ready states 👀👀👀
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From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science https://t.co/Fua3YQ8XPt
nature.com
Nature - From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.
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With our RTI colleagues Xiaobin Ling and @WenwenFang2, we report cryo-EM structures of enigmatic bacterial RNA nanocages made of long-noncoding ROOL RNAs. Octamers are held by "A-minor staples" and other interactions. Congrats Xiaobin, Dima et al! https://t.co/kThZa5hsMS
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🧬AlphaFold3 nails protein structure prediction ... except for 48% of the interactome 😅 PIONEER2.0 blends homology + DL to map interfaces for 352k human PPIs, beating AF3 where it falters.
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🚨New paper🚨 Excited to share our latest on @Nature today: The PIVOT PENALTY in research. https://t.co/V4ENiGCssY More than five years in the making. Key finding: The impact of new research steeply declines the further a researcher moves from their previous work.
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A sobering message from a history teacher: I’ve spent years teaching American and international government — from strong democracies like the UK to authoritarian regimes like russia and China. But lately, the most alarming lesson comes from home. 1/n
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You want to start tomography? Solve structures inside cells? Reach Nyquist😳? We have a website for you! https://t.co/ulvbbhEY6d You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomo averaging, using different software! Hope it will be useful !
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Hey ChimeraX users! ChimeraX-CliX now supports color preview, quick menubar/toolbar search, and many other powerful features to support you. If you are interested in, please download the latest version -> https://t.co/n95MTEAv1b
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Excited to share our latest work on the structure and mechanism of the ancient sodium-pumping Rnf complex, now out in @NatureComms
nature.com
Nature Communications - The Rnf complex is a key respiratory enzyme of anaerobes and nitrogen-fixing bacteria. Here, the authors combine structural, computational, and biochemical experiments to...
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Scientists have long known that histones spool DNA and help regulate genes. They may be doing a lot more. https://t.co/iMRKxyBRRO
asbmb.org
Scientists have long known that histones spool DNA and help regulate genes. They may be doing a lot more.
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incredible breakthrough: a protein from tardigrades can now protect human cells from radiation. healthier cancer therapies, longer space missions, and real-world longevity treatments are coming. 1/
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I am very happy to announce that we solved the in-virus #cryoEM structure of the #HIV matrix protein. The structure helped us to resolve a long mystery in HIV biology. A🧵1/5 Read more in @Nature : https://t.co/rVDC5LomAn 🧪
Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @MargotRiggi :
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Impact of the PDB on drug approvals Open access to the PDB facilitated discovery/development of 100% of the 34 new low molecular weight, protein-targeted, antineoplastic agents approved by the US FDA 2019–2023. Read more in Oncogene https://t.co/N7GVXne9ys
nature.com
Oncogene - Impact of structural biology and the protein data bank on us fda new drug approvals of low molecular weight antineoplastic agents 2019–2023
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Optical nanoscopy, but without the OFF...! Published in @NaturePhysics by T.A. Hensel, J.O. Wirth, O.L. Schwarz & S.W. Hell. Check it out with open access at https://t.co/T3KuhjMolg
@mpi_nat @mpi_mr_hd #Imaging #Optics #Waves #Microscopy
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I am eager to look into this model, but having only skimmed the paper, here are two thoughts: 1. I don't believe any claim of computational design unless you synthesize the DNA, put it in a real cell, and show that the design functions as expected.
Evo-2 has demonstrated practical generation abilities, creating synthetic yeast chromosomes, mitochondrial genomes, and minimal bacterial genomes. this is computational design in action. 6/
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HOLY SHIT IT'S HAPPENING AI can now write genomes from scratch. Arc Institute an NVIDIA just published Evo-2, the largest AI model for biology, trained on 9.3 trillion DNA base pairs spanning the entire tree of life. it doesn’t just analyze genomes. it creates them 1/
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