Wilhelm Lab
@LabWilhelm
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Research group studying metabolic and dietary control of mucosal immunology - led by Dr. Christoph Wilhelm at the University of Bonn
University of Bonn
Joined December 2019
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation | Nature Immunology
nature.com
Nature Immunology - Tuft cells constitutively express IL-25 to sustain ILC2 homeostasis in the intestine, but mechanisms driving IL-25 secretion have been unclear. Here, Feng et al. find that tuft...
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We are hiring! 📣Interested in how host metabolism, diets, #fasting and #ketogenesis affect the immune response? 👇We are offering a #postdoc position to work on the interplay of host metabolism and immunity. Apply by email or DM directly.
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RT @DagmarWachten: Thrilled to announce that our #SFB1454 got funding @UniBonn @IIIBonn #Metaflammation.
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Thanks so much DFG for funding our CRC #1454 #Metaflammtion for another 4 years. Looking forward to unravel the immune mechanisms underlying #obesity and #diabetes together with an excellent team of scientists. @UniBonn @ImmunoSens.
Die #DFG richtet zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 7 neue #Sonderforschungsbereiche (SFB) ein. Die Themen reichen von Materialübergängen oder der Wiedervernässung von Mooren bis zur Immunregulation in der Leber. Einzelheiten:.➡️
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RT @LabWaggoner: Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation @Fer_NK_nando.@….
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RT @surace_laura: 🚨 last weeks 🚨 .1 phd position available in our Lab !.If you are interested in tumor immunology and immunometabolism cont….
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Congratulations Anna, Ari and colleagues, really love the story!.
Our latest paper with @Molofsky_lab is out! tweetorial to follow. Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior | Science . @jerika_barron @ Nick Mroz.
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Neuropeptide signalling orchestrates T cell differentiation | Nature
nature.com
Nature - RAMP3, a component of the receptor for the neuropeptide CGRP, has a cell-intrinsic role in T helper type 1 cell fate determination.
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RT @LMackayLab: 1/ 🚨 Hot off the press! 🚨Our new paper, led by @ObersAndreas & @maxevrard, is now live in @ImmunityCP! 🧬 Curious how CD8+ t….
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RT @ChSchneider_PhD: Not the first and likely not the last review on tuft cells. But for sure the most recent one, published in @NatRevGast….
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RT @surace_laura: We are looking for a highly motivated PhD Student! 🤩.If you are passionate about science and interested in tumor immunolo….
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RT @bart_lambrecht: We describe that Il-9 and Il-21 have partially overlapping and synergistic effects in asthma. Check out .
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RT @JanSiemens2: Very proud of our discovery: a heat-induced CNS plasticity mechanism that drives heat tolerance. I had hoped for it to com….
biorxiv.org
Heat acclimation is an adaptive process that improves physiological performance and supports survival in the face of increasing environmental temperatures. Understanding the underlying mechanisms...
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Congratulations Prof. Surace @surace_laura, welcome to the faculty of @UniBonn and the @ImmunoSens 🥳🥳🥳 We are super happy to have you join, great things to come. #newPI #immunometabolism #ILC
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RT @Brenner_Lab: Excited to share our new publication @Cell_Metabolism! GSH in Th17 cells is crucial for gut barrier integrity, controls mi….
cell.com
Bonetti et al. show that glutathione’s (GSH) control of mitochondrial reactive oxygen species (ROS) in Th17 cells is critical to maintain intestinal barrier integrity during bacterial gastrointesti...
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Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity: Immunity
cell.com
Dietary restriction is associated with improved elimination of cancer cells, and fasting regimens are being tested in clinical settings in combination with cancer therapies. Using a cyclic fasting...
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RT @ScientistBecs: Thrilled to have this story out online @ImmunityCP!! Together with @SunLab_Official, we highlight how dietary fasting im….
cell.com
Dietary restriction is associated with improved elimination of cancer cells, and fasting regimens are being tested in clinical settings in combination with cancer therapies. Using a cyclic fasting...
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Phage display screening to identify commensal antigens. Congratulations Ollie @harrison_oj and colleagues 🥳! #microbiota #Bcells
cell.com
Adaptive immunity to commensal microbes promotes tissue homeostasis, immunity, and repair, but approaches to identify commensal-specific B cell responses are lacking. Verma et al. utilize phage...
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Congratulation Dagmar and team! Will go on my ‘to read’ pile.
Thrilled that our huge team effort with @Kornfeld_JanW is out in @NatMetabolism 🥳 supported by @TRR_BATenergy A huge thank you to all collaborators! If you want to know how a truncated AC3 isoform regulates #BAT function, have a look here
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