Wilhelm Lab
@LabWilhelm
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Research group studying metabolic and dietary control of mucosal immunology - led by Dr. Christoph Wilhelm at the University of Bonn
University of Bonn
Joined December 2019
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation | Nature Immunology
nature.com
Nature Immunology - Tuft cells constitutively express IL-25 to sustain ILC2 homeostasis in the intestine, but mechanisms driving IL-25 secretion have been unclear. Here, Feng et al. find that tuft...
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We are hiring! 📣Interested in how host metabolism, diets, #fasting and #ketogenesis affect the immune response? 👇We are offering a #postdoc position to work on the interplay of host metabolism and immunity. Apply by email or DM directly.
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Die #DFG richtet zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 7 neue #Sonderforschungsbereiche (SFB) ein. Die Themen reichen von Materialübergängen oder der Wiedervernässung von Mooren bis zur Immunregulation in der Leber. Einzelheiten: ➡️ https://t.co/kXJWN77KRp
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Thanks so much DFG for funding our CRC #1454 #Metaflammtion for another 4 years. Looking forward to unravel the immune mechanisms underlying #obesity and #diabetes together with an excellent team of scientists. @UniBonn @ImmunoSens
Die #DFG richtet zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 7 neue #Sonderforschungsbereiche (SFB) ein. Die Themen reichen von Materialübergängen oder der Wiedervernässung von Mooren bis zur Immunregulation in der Leber. Einzelheiten: ➡️ https://t.co/kXJWN77KRp
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Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation @Fer_NK_nando
@TimMcCulloch
https://t.co/aev8ZBefxb
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🚨 last weeks 🚨 1 phd position available in our Lab ! If you are interested in tumor immunology and immunometabolism contact us … info 👇 … 🙏 RT
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Congratulations Anna, Ari and colleagues, really love the story!
Our latest paper with @Molofsky_lab is out! tweetorial to follow. Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior | Science https://t.co/u2fQ2j2OeN
@jerika_barron @ Nick Mroz
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Neuropeptide signalling orchestrates T cell differentiation | Nature
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1/ 🚨 Hot off the press! 🚨Our new paper, led by @ObersAndreas & @maxevrard, is now live in @ImmunityCP! 🧬 Curious how CD8+ tissue-resident memory T cells (TRM) adopt their fate in different organs? Let’s dive in! 🧵👇 https://t.co/vcgpgMgBcZ
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Not the first and likely not the last review on tuft cells. But for sure the most recent one, published in @NatRevGastroHep: Kalle and @XiaogangFeng did a great job summarizing recent findings related to tuft cells https://t.co/sIpiMcZj57 full-text access: https://t.co/7aGTYO8aSs
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We are looking for a highly motivated PhD Student! 🤩 If you are passionate about science and interested in tumor immunology and metabolism… join us in Bonn! 👩🏻🔬👨🔬 please share🙏
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We describe that Il-9 and Il-21 have partially overlapping and synergistic effects in asthma. Check out https://t.co/rDkRQ3beo7 Nice collab with @BenjaminMedoff in MGH and @argenxglobal Revive Il-9 !
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Very proud of our discovery: a heat-induced CNS plasticity mechanism that drives heat tolerance. I had hoped for it to come out 2 years ago, but I tried too hard with @nature and after several rounds of revisions they rejected it – see/judge yourself.
biorxiv.org
Heat acclimation is an adaptive process that improves physiological performance and supports survival in the face of increasing environmental temperatures. Understanding the underlying mechanisms...
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Congratulations Prof. Surace @surace_laura, welcome to the faculty of @UniBonn and the @ImmunoSens 🥳🥳🥳 We are super happy to have you join, great things to come. #newPI #immunometabolism #ILC
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Excited to share our new publication @Cell_Metabolism! GSH in Th17 cells is crucial for gut barrier integrity, controls mitochondrial ROS & transcription, ATP & links to IL-22 translation. Huge thanks to Lynn Bonetti @LIH_Luxembourg & our collaborators. https://t.co/09jGfCaEaK
cell.com
Bonetti et al. show that glutathione’s (GSH) control of mitochondrial reactive oxygen species (ROS) in Th17 cells is critical to maintain intestinal barrier integrity during bacterial gastrointesti...
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Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity: Immunity
cell.com
Dietary restriction is associated with improved elimination of cancer cells, and fasting regimens are being tested in clinical settings in combination with cancer therapies. Using a cyclic fasting...
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Thrilled to have this story out online @ImmunityCP!! Together with @SunLab_Official, we highlight how dietary fasting improves NK cell anti-tumor immunity and examine the tissue-specific processes that drive these improved responses 🧵 https://t.co/QpyLoMqHoH
cell.com
Dietary restriction is associated with improved elimination of cancer cells, and fasting regimens are being tested in clinical settings in combination with cancer therapies. Using a cyclic fasting...
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Phage display screening to identify commensal antigens. Congratulations Ollie @harrison_oj and colleagues 🥳! #microbiota #Bcells
cell.com
Adaptive immunity to commensal microbes promotes tissue homeostasis, immunity, and repair, but approaches to identify commensal-specific B cell responses are lacking. Verma et al. utilize phage...
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Congratulation Dagmar and team! Will go on my ‘to read’ pile.
Thrilled that our huge team effort with @Kornfeld_JanW is out in @NatMetabolism 🥳 supported by @TRR_BATenergy A huge thank you to all collaborators! If you want to know how a truncated AC3 isoform regulates #BAT function, have a look here
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