JK Nandakumar lab
@LabNandakumar
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Professor @UMich_MCDB dept of @umichLSA College at the University of Michigan (@umich) Views/posts are JK's
Joined April 2019
RT @simanshu: BBO-10203 is currently being evaluated in the Phase 1 BREAKER-101 trial (NCT06625775) in patients with HER2+ and HR+/HER2- br….
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RT @simanshu: This publication describes how BBO-10203 disrupts the RAS–PI3Kα interaction without impairing insulin signaling, resulting in….
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RT @simanshu: We are excited to share our collaborative work on the first-in-class RAS:PI3Kα breaker, BBO-10203, which has now been publish….
science.org
BBO-10203 is an orally available drug that covalently and specifically binds to the RAS-binding domain of phosphoinositide 3-kinase α (PI3Kα), preventing its activation by HRAS, NRAS, and KRAS. It...
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RT @MGodinhoFerr: Happy to share our new paper! 🎉.We show that #cGAS–#STING inflammation drives premature #aging in response to telomere sh….
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RT @MingLi_Umich: New paper from the lab. We collaborated with the legendary Stuart Kornfeld lab to study the molecular mechanisms of how T….
biorxiv.org
In vertebrates, newly synthesized lysosomal enzymes traffick to lysosomes through the mannose-6-phosphate (M6P) pathway. The Golgi membrane protein TMEM251 was recently discovered to regulate...
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RT @simanshu: Our structural-guided insights contributed to the design of BBO-8520, a first-in-class dual inhibitor targeting both GTP-boun….
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RT @KellyTHD_Nguyen: Last week, we said farewell to the first postdoc of our lab, George Ghanim @AutomneNine who will start his own lab at….
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RT @MGodinhoFerr: “We highlight the differences between human and mouse telomere biology that may contribute to discrepancies between human….
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RT @NilsWalterLab: In @ScienceMagazine - great collaborative work w/ @AlbertW_Lab & @RappsilberLab showing that bacterial RNA polymerase ca….
eurekalert.org
An international team of scientists have used advanced microscopy to image how ribosomes recruit to mRNA.
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RT @AChemSynBio: Happy to share Elise and Tarah’s work on building a facile selection system to engineer E. coli leucyl synthetase for site….
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RT @UMich_MCDB: MCDB's Kozik Honored by Microbiology Society | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB) .
lsa.umich.edu
International organization honors Kozik and her cofounders of the Black Microbiologists Association with the 2025 Equality, Diversity and Inclusion Prize 2025
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RT @MolecularCell: In our #RNA focus issue, we invited viewpoints from three groups on the controversy over PRC2-RNA interactions and asked….
cell.com
Diverse biochemical, structural, and in vivo data support models for the regulation of polycomb repressive complex 2 (PRC2) activity by RNAs, which may contribute to the maintenance of the epigenetic...
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RT @Cornell: Ratan Tata ’59, B.Arch. ’62, the university’s most generous international donor and one of India's most respected business lea….
news.cornell.edu
Ratan N. Tata ’59, B. Arch. ’62, one of India’s most influential and respected business leaders and philanthropists, and a former Cornell trustee who became the university’s largest international...
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RT @cijilim: 1/8 ❄️🔬Excited to share our latest work published in @NatureComms! Led by @kaitlyn_m_abe and in colab with @GrantCryoEMLab, we….
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RT @vikasnavaratna: I've submitted my first ever tenure-track job application. Officially, I'm on tenure-track job market. My major interes….
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RT @CterminiPhD: Ladies who lead in diversity, equity, and inclusivity!!! Congrats on a well deserved honor, @TheKingLab ♥️🩸#ISEH2024.
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RT @hemanth_tummala: Just out today we report a new X linked loci…and several novel variants in telomere biology disorder Dyskeratosis con….
embopress.org
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RT @zhtianp2: The Zhang Lab website is online now: We are interested in Genome Integrity Maintenance within Repet….
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RT @MicrobiomDigest: AI can be used to make convincing looking fake data. There is no way we can distinguish real from fake anymore. It is….
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