Saying goodbye to Twitter! Follow me to Bluesky!

Microbes support normal blood production! Authors in this recently published article report on the microbes and microbial metabolites missing from pediatric patients with antibiotic-associated neutropenia. @TheKingLab 👉 https://t.co/Cy8eQa4hjL

Confused about possible biomarkers for blood cell aging? Check out this review by Wolfgang Wagner, including exploration of how transferable such markers are between mice and humans - Experimental Hematology https://t.co/yEnkxJz6Hn @ISEHSociety @ELShematology

Find out what this is about— find me at BlueSky social: @TheKingLab !

A great collaboration with @baldridge_lab @WUSTL and Ritu Banerjee @VUMCchildren. Congrats to Josie Fernandez Sanchez who spearheaded this work and @ArushanaMak03 HannahYan Jeremy Schraw Rachel Rodgers and many more who contributed to this work @Hemasphere_EHA

In future work we hope that we can use some of these metabolites to rescue antibiotic- associated neutropenia, making antibiotics safer to use.

Stool metabolomics revealed a number of differentially abundant metabolites including members of the uridine synthesis pathway.

Amazingly, those who developed neutropenia had depletion of a specific class of microbiota: Lachnospiraceae. These bacteria have been reported to impact outcomes from HSCT and to be significant producers of short chain fatty acids.

We did not find correlation with any particular antibiotic or infection type.

Patients on longer courses of antibiotics, especially IV antibiotics, and with ICU stays were more likely to get neutropenia.

Sure enough, 17% of prospectively enrolled subjects developed some degree of neutropenia.

We enrolled pediatric patients @TexasChildrens and @VUMCchildren and collected stool samples at the start and end of prolonged antibiotic courses (2 weeks or more) 💩

It’s here! Our first actual clinical study re: #microbiota changes in antibiotic-associated neutropenia. https://t.co/nITLXOKayR @TCHResearchNews @CAGTHouston @BCMFromtheLabs @BCMPedIDFellows

Also, thanks photo credit Philip Burkhardt

Happy Halloween!!! Reasons to work at a children’s hospital…@CAGTHouston @BCMFromtheLabs

Thank you @majetilab for visiting us @CAGTHouston @bcmhouston ! You blew us away with your cool technology and insights into AML pathogenesis and future therapies. I neglected to take pictures so sharing some seasonal fun instead.

Thanks to @A_Thatavarty for seeing this story through. @ISEHSociety

Another piece of the puzzle in our quest to discover how interferons disrupt HSC quiescence and promote differentiation.

Instead @MarcusAFlorez found that BST2 affects lipid raft formation and promotes ERK signaling.

Since BST2 is a surface protein we thought it might work by affecting HSC niche localization…. But not so.