Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by @conor_loynd, @SinghaSoumya, and @SCanarelli! We introduce a new generation of BONCAT tools for versatile characterization of newly synthesized proteins in pathogenic bacteria

A facile chemical strategy to synthesize precise AAV-protein conjugates for targeted gene delivery

Cool work from @Han_Xiao2016 on site-specific incorporation of an environment-sensitive fluorescent noncanonical amino acid to visualize protein microenvironment changes in living cells

Our work @cgem_cci on co-translational incorporation of a noncanonical monomer into a protein, followed by its triggered post-translational chemical rearrangement, yielding novel backbone modifications.

Happy to see this new T7 replicon based orthogonal replication system in E. coli. Congrats to the Diercks and Schultz lab teams at Scripps Research!

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @AmanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share! https://t.co/cyVZpAwJiq

Today in @ScienceMagazine we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells, a collaboration with @SternbergLab. 1/13 https://t.co/ZLHtZm5Gmw

Writing in @J_A_C_S, we report a sugar-derived single-addition monomer that can be added together with other monomers in #ROMP and install functional groups at the chain end of metathesis polymers. #glycotime #polymer #NSFfunded https://t.co/uezAc9OdZ0

NIH is centralizing peer review of all applications for grants, cooperative agreements and research and development contracts within the agency’s @CSRpeerreview. This is expected to save NIH more than $65 million annually & make the review process more efficient.

This isn't science fiction. This is real sequencing biotechnology just introduced by Roche. Wild and wonderful.

We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their

Basic science is inspired by curiosity, accountable to evidence, and subject to peer review. Politics should have no role.

1/ After residency at Mass General Hospital, I reported to Atlanta to meet my fellow CDC Epidemic Intelligence Service Officers. I have never felt so intimidated by my peers The best and the brightest, they were star clinicians, had served in disaster zones; MD/PhDs and MSF.

An excellent primer on indirect costs

Thrilled (and relieved) to finally have this review by Arianna, Zeyi, and Kaitlyn out! Everything you've ever wanted to know about genetic code expansion in mammalian cells!

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis

Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above

This rate of validation suggests that antibodies should be considered non-specific until proven otherwise: 357 validated out of 1,124 tested. .

Happy to share Elise and Tarah's work now out @angew_chem!

Continuous directed evolution of cyclic peptides in cells to inhibit protein aggregation