New science out from our group, this time looking at the specificities of autoantibodies in patients with juvenile idiopathic arthritis #JIA.

🌍 QuantumScale training sessions happening across continents! Same commitment everywhere: Your breakthrough = our success Real support. Real results. Real partnership. https://t.co/HOdLtPpK9J #GlobalScience #SingleCellRNA #ScaleBio

Interesting observation: turns out mouse PD-1 is less inhibitory than human PD-1, so many observations in mouse cancer immunotherapy models may not hold true in humans. Another fine example why we need more human studies and/or more humanized rodent models.

An exciting advance in Type 1 diabetes First person to receive her own stem cells, reprogrammed with transcription factors, to reverse it! @CellCellPress https://t.co/NzhTO6tZrg @Nature https://t.co/zbNNtLCrot

Huge congratulations @SchAnnMari for brilliantly defending your thesis today! And many thanks @lettipitko for acting as the opponent and leading the inspiring discussions.

Doctoral defence of Anna-Mari Schroderus, MSc, 13 Dec 2024: Alterations in T-cell landscape observed at different stages of type 1 diabetes progression. @ClinmedUef @UEFMetabolicRC

T-solupopulaatioissa tapahtuu tyypin 1 diabeteksen kehittymisen eri vaiheissa muutoksia, joista voisi ehkä tulla biomarkkereita hoitoon, havaitsi FM Anna-Mari Schroderus väitöstutkimuksessaan. Väitös Kuopiossa 13.12.2024. @ClinmedUef @UEFMetabolicRC

Interesting early success by CAR-T therapies to treat (highly selected!) patients with severe autoimmune diseases, like lupus.

New paper out @Nature - why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? sex chromosomes or hormones? Here we studied adaptation of human immune systems to gender-affirming

Ok, so this is the future I guess. Someone made an AI-generated 30 sec highlight of our research paper. Looks and sounds very convincing on the surface, but on a closer look the pictures and texts in the animation are complete gibberish…

5/ Thanks again to all the collaborators at @ClinmedUef @helsinkiuni @UniTurku @UniOulu, and of course the funding sources @SuomenAkatemia @SigridJuselius

4/ The mechanism is completely speculative, but recently there have been some evidence for a protective effect on autoimmunity for certain subsets of highly differentiated CD8+ T cell subsets, such as the CD8+KLRG1+TIGIT cells, we recently studied in #T1D:

3/ So, what does this have to do with autoimmunity? Not necessarily anything, but there are some signals that early life CMV infection may protect from autoimmunity, such as our earlier study some years ago:

3/ As expected based on earlier research, increased frequencies of memory T cells with an ”advanced differentiation” phenotype were observed early after infection, and the increase in the most highly differentiated memory T cells persisted into the latent phase (6 years of age).

2/ #CMV is know to alter the memory T cell compartment, in particular CD8+ T cells drastically. However, most earlier studies have analyzeded adult subjects. Here, we used samples from the #DIPP study to analyze T cells at 6 months and 6 years of age following early CMV infection

1/ Check out our recent translational research on the effect of early life CMV infection on T cell memory in children! https://t.co/2DyInckWhk

Verenkierron CD8-positiivisissa T-soluissa tapahtuu erityyppisiä muutoksia tyypin 1 diabeteksen kehittymisen eri vaiheissa, osoittaa Itä-Suomen yliopiston tutkimus. Tieto voi auttaa tyypin 1 diabeteksen kehittymisen ennustamisessa. @KinnunenLab @SchAnnMari

Two distinct signatures were detected in a subset of circulating, highly differentiated CD8-positive T cells in children at different stages of type 1 diabetes development. The study was led by prof. Tuure Kinnunen at the #UEF. @KinnunenLab @SchAnnMari https://t.co/cGiiWA4mHA

6/ I wish to thank all our collaborators at @ClinmedUef @Pshyvinvointi @helsinkiuni @UniTurku, and especially my brilliant student @SchAnnMari, who spearheaded the project! Special thanks also to the funders: @SuomenAkatemia @SigridJuselius

5/ Therefore, it can be speculated that in at-risk individuals there is an ongoing immune process aiming to restrict autoimmunity, which is reflected by increased blood CD8+KLRG1+TIGIT+ cells, and this could potentially be enhanced by immunotherapy to prevent the onset of T1D