Enfu Hui
@hui_enfu
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Professor @UCSanDiego @ucsdbiosciences Biologist, husband, dad, nerd 🤓, and 🎾 fan.
UC San Diego
Joined August 2015
Thrilled to share our @SciImmunology paper! Rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. Kudos to @MasubuchiTakeya for leading
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The Program in Immunology welcomes Dr. Joseph Sun @SunLab_Official from @MSKCancerCenter and @WeillCornell. Please join us for his seminar on Wednesday February 5!
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663 days since the senseless tragedy that took An, we present a manuscript that reports some of the discoveries that she left us. https://t.co/hEbu4OfH1E
biorxiv.org
During the execution of learned motor skills, the neural population in the layer 2/3 (L2/3) of the primary motor cortex (M1) expresses a reproducible spatiotemporal activity pattern. It is debated...
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Our work by Anna Huhn @annagesine is now published @NatureComms ! https://t.co/2T8Uqz5CVG We show that the antigen contributes to the overall reach of the antibody, and that this molecular reach determines antibody function. Thank you to the reviewers for constructive feedback!
Antibodies are bivalent molecules but we study/optimise them based on their monovalent binding. New work provides a simple method to analyse & predict bivalent binding! The molecular reach of antibodies determines their SARS-CoV-2 neutralisation potency https://t.co/ne69K0qDWi
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Scientists have identified functional differences between human and mouse #PD1, which could impact preclinical research on cancer #immunotherapies. @hui_enfu @jackbuimdphd @UCSanDiego Learn more in Science #Immunology: https://t.co/WDYLKxUkkn
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Excited to share our latest paper describing the functional divergence of PD-1 across species. Thank you for @hui_enfu for the invaluable guidance, and @jackbuimdphd @ZhengtingZou @CWu2009 et al. for wonderful collaboration! https://t.co/sB6Y2F34LB
https://t.co/AwJf8Z5lCA.
today.ucsd.edu
Much of our knowledge of the protein PD-1, a leading cancer treatment target, comes from studies in mice. In a comprehensive assessment of PD-1, researchers have found that PD-1 in mice is signific...
Thrilled to share our @SciImmunology paper! Rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. Kudos to @MasubuchiTakeya for leading
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Today in Science Immunology: Much of our knowledge of PD-1, a leading cancer target, comes from studies in mice. @UCSanDiego researchers found that PD-1 in mice is much weaker than the human version, providing new information for future cancer treatments. https://t.co/89NGld6NOn
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A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity @SciImmunology @hui_enfu @jackbuimdphd
https://t.co/6WLVkjuquE
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Delighted to share our new preprint on the cell biology and genome of Stentor pyriformis, a giant ciliate that maintains Chlorella endosymbionts in surface-associated microtubule baskets. https://t.co/JUzsBexIWq
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Excited to share our work, new in @ScienceMagazine: https://t.co/i5l29g85zT. We explored how sex chromosomes, gonadal hormones, and their interaction shape cellular responses in aging and #Alzheimers mouse models. This led to key insights on Tlr7 and neurodegeneration 🧵(1/5)
science.org
Alzheimer’s disease (AD) and other age-related disorders associated with demyelination exhibit sex differences. In this work, we used single-nuclei transcriptomics to dissect the contributions of sex...
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🔬 Are you eager to dive into the world of light microscopy and learn from top-notch microscopists about its essential techniques for life science applications? If that sounds exciting, don’t miss out on this free, in-depth iBiology series! 👉 https://t.co/IgKwGlQKPg
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The best department to thrive in ♥️♥️♥️ APPLY APPLY APPLY!!!
The Department of Cell and Developmental Biology in the School of Biological Sciences ( https://t.co/Szxu7b4YZq) announces an open search for Project Scientists (non-tenured, Assistant, Associate or Full Level). Apply at https://t.co/1KMXdgkMuE
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#NewIssue On the cover: In this issue of Cell Metabolism, Li et al. reveal that sick neurons release lipids to the glia, causing lipid droplet accumulation and neuroinflammation. The artwork, inspired by Van Gogh's Starry Night, depicts a brain with lipid droplets. Artwork by
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THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA | PNAS
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P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi
biorxiv.org
Innate immunity, the first line of defense against pathogens, relies on efficient elimination of invading agents by phagocytes. In the co-evolution of host and pathogen, pathogens developed mechani...
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The Program in Immunology congratulates Professors Sue Kaech @Tcellogic and Steve Hedrick on their election to the National Academy of Sciences! https://t.co/qnZmDD1UJI
@salkinstitute @ucsdbiosciences
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Hi all, what is happening to foreign scientists in Florida is horrible. Pls Join and donate to AAPI orgs in Florida to help us sustain recruiting amazing scientists from Asia to America. As we have seen with RvW, this mentality can easily spread across the country.
The passage of Florida's SB 264 is a devastating blow to the civil rights of Chinese immigrants and Asian Americans alike. “America was the beacon of the world," said University of Florida Professor Zhengfei Guan, "and now that beacon has collapsed.”
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Collaborating with Dr. Xu Chen @xuashleychen1 Dr. Yajuan Li, MD PhD imaged brain microglial lipid droplets accumulation under tauopathy condition with DO-SRS, which is further proof that newly synthesized lipid droplets plays an important role in brain cell energetics, echoing
New! Online now: Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK https://t.co/JJrwxuLGBK
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Excited to share our work @Cell_Metabolism: What happens when sick neurons dump fat to glia? We saw it by eye using @StimulatedRaman 🔬 https://t.co/ltlhxrpjH1 Congratulations to all the authors and our wonderful collaborators!🙌
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