Kim Seed
@KimDSeed
Followers
1K
Following
590
Media
14
Statuses
298
Associate Professor at UC Berkeley studying viruses that infect pathogenic bacteria
Joined June 2017
Excited to share our recent pre-print! The Vibrio cholerae encoded Nezha anti-phage system (SIR2-HerA) restricts virulent vibriophages ICP1, ICP2, and ICP3 by depleting NAD+ (Abi💀). However, an ICP1 isolate can overcome this by encoding putative NAD+ regenerating proteins! ⚡️
A Vibrio cholerae Anti-Phage System Depletes Nicotinamide Adenine Dinucleotide to Restrict Virulent Bacteriophages https://t.co/E5b4np77hs
#biorxiv_micrbio
3
18
52
Please RT: @gem__atkinson is looking for a computational PhD student on a phage-bacteria interaction Data-Driven Life Science (DDLS) / @scilifelab project. @anfossati is a co-pilot. https://t.co/HCK6EKGqJ9 more info re the project here https://t.co/h6CAUBAmEw
atkinson-lab.com
We are looking for a full-time bioinformatics PhD student to be involved in the DDLS project “Finding the prophages of Escherichia coli genomes and annotating the function of their genes usin…
0
42
47
Really excited to share my first preprint as a postdoc! Here, we determined that the BREX-inhibitor, OrbA, encoded by the lytic phage ICP1 inhibits BREX through the ATPase BrxC in V. cholerae. https://t.co/DKPyKcBWDW
biorxiv.org
Bacteria and phages are locked in a co-evolutionary arms race where each entity evolves mechanisms to restrict the proliferation of the other. Phage-encoded defense inhibitors have proven powerful...
2
9
51
Woohoo, our paper on the discovery of 65 new phages dependent on conjugative plasmids is published in it's final form today in @NatureComms ! Here follows a thread (1/ )
link.springer.com
Nature Communications - Some phages use plasmid-encoded conjugation proteins as receptors to infect their bacterial hosts, making their host range dependent on horizontal transfer of the plasmid....
7
87
308
🦠What are the early-life colonization & assembly dynamics of bacteriophages? Out today online in @cellhostmicrobe, our paper took a strain-resolved approach to investigate early phage colonizers. Article: https://t.co/C74GsnNFAB
9
39
116
It's out! This paper on phage RNA-mediated activation of bacterial CBASS systems should activate your interest in reading it 🧪🦠🪐📑 @daltonbanh @camgroberts @MarraffiniLab
https://t.co/9qQqdw7sga
1
31
105
Attention phage/microbiology 🧫🦠enthusiasts- my lab https://t.co/jX1gjqbCeu
@UCBerkeley is hiring a staff research associate, an ideal opportunity for folks looking to gain research experience before grad school/professional school https://t.co/51KXJIjCXk please share!
kimseedlab.com
Kim Seed is an Assistant Professor at the University of California, Berkeley and her lab studies the interactions between bacteria and their viral predators (bacteriophages), and how these interact...
6
62
91
Story time: when I started my postdoc with @WatersLabMSU in August last year, we aimed to use V. cholerae to understand how genetic interactions, including epistasis and pleiotropy, influences its pathogenesis and evolution. 1/18
4
43
200
@jwmodell lab and I are excited to celebrate #WorldPhageWeek this year with our new preprint, showing how CRISPR-Cas9 systems can respond to phage-encoded anti-CRISPRs and ultimately counterbalance Acr-phage infections!
biorxiv.org
CRISPR-Cas immune systems provide bacteria with adaptive immunity against bacteriophages, but they are often transcriptionally downregulated to mitigate autoimmunity. In some cases, CRISPR-Cas...
1
14
46
Deadline extended! Come be our colleague at UC Berkeley! Assistant Professor - Phylogenomics and Molecular Epidemiology of Pathogens with Pandemic Potential Final application date: Nov 5, 2023 11:59pm (PST) https://t.co/bbPOgMVb4y Info on salary scale
0
15
17
Any #phage or #giantvirus postdocs interested in reviewing manuscripts can DM me your name and contact info. We can chat about your experience and I have reviewing guides prepared to help you get started if interested
1
5
2
Latest from the lab! Here we report the discovery of widespread famly of PICIs that just hijacks tails from their helper phages. Amazing collaboration with @epcrocha @doctor_jams @JchenLab. Fantastic work from @Alqurainyn Miguel-Romero & @AlfredFillol
cell.com
Alqurainy et al. discovered a widespread family of phage satellites encoding all the proteins required to produce small capsids, where satellite genomes are exclusively packaged. Therefore, to...
1
40
115
The latest on the ongoing battle between a phage and its parasite https://t.co/VCnyjzGBhZ check out summary by @MariaHTNguyen
My first first-author paper is out for the world to read!!! 🥳 Quick summary below👇:
0
3
23
We're recruiting a postdoc to join our lab to work on #herpesvirus molecular machines 🔬🧪🧬 please share with anyone who might be interested! #kshv #lovevirology #molecularbiology #postdocjobs #postdocposition #scitwitter
10
185
320
The Dep. of Plant & Microbial Biology @ the @UCBerkeley is hiring a Postdoc in the area of #phage-host interactions. They'll conduct research as part of Dr. @KimDSeed’s grant 2 explore how mobile genetic elements contribute 2 phage resistance in V.cholerae https://t.co/BIGyWXUN6Y
0
10
17
The field is going so fast, we are doing our best to keep up :). DefenseFinder now includes wonderful new systems including but not limited to: https://t.co/9gcdxjw395 ; https://t.co/Ke1lxjiJbM ; https://t.co/RDiauJBTmb ; https://t.co/VQqbJGxERV and a bunch of old ones ^^.
academic.oup.com
Abstract. Reverse transcriptases (RTs) are enzymes capable of synthesizing DNA using RNA as a template. Within the last few years, a burst of research has
New release alert: DefenseFinder v1.2.0 is out. When published in May, DefenseFinder included 60 systems, v1.2 now includes 130 systems. Available online and as command line (--update). Thks for all the people who reported bugs and new systems ! https://t.co/XgudeYX4sR
1
12
74
Interested in phage-bacterial interactions (or more accurately...phage-MGE conflict)? Consider my lab @UCBerkeley for a postdoc! Information on the position https://t.co/o9os57gIQn, contact me with any questions
0
79
135
Our preprint @joeBondyDenomy on a newly discovered bacteria immune system against a group of nucleus-forming jumbophages is out ( https://t.co/t6fqC3YJOW). We named this immune system “JUmbophage Killer” (Juk). 1/n
4
70
222
