RT @deniswirtz: Research Saves Lives . At Johns Hopkins, we just went live with an expansive website showing the extraordinary value of re….

RT @NatureMicrobiol: OUT NOW 🦠 Prediction of strain level phage-host interactions across the Escherichia genus using only genomic informati….

RT @alexjmeeske: Many bacteria have >1 CRISPR system, and they affect each other! @shallymarg found a 3-way interaction that leads to prime….

RT @AudeBer: From bacteria to human immunity! . On our quest to idendify eukaryotic homologs of antiphage systems, we discovered a family o….

Cas proteins in disguise?? Halloween came early this year! 🎃🥸.

RT @SternbergLab: We're excited to see our recent work on multi-functional transposons now in press. Nucleases and guide RNAs and catalytic….

RT @NilsBirkholz: 👋🏻 I'm absolutely glee-ridden to finally see our study on the RNA- and DNA-binding anti-CRISPR repressor Aca2 published i….

RT @dbikard: 1/ 🧵 Thrilled to share work of @EligoBio just published in @Nature ! We show proof of principle results of efficient base edit….

Marie’s paper is out! We previously showed that Cas9 represses its own promoter to avoid autoimmunity. Marie now shows that this repression generates a mutant subpopulation of CRISPR-Cas overexpressors that expand and contract in response to phage pressure.

RT @APHage_: If you've induced phages, you may have wondered if you can do the 'opposite' - block entry into lysogeny. You can, using prote….

RT @stephentang23: I am delighted to share the newest work from the @SternbergLab, in which we discover RNA-templated gene creation as a me….

RT @RegotLab: Connor's paper is out in Science! Thanks to all the present and former lab members for making this possible. If you are inter….

RT @jrpenades: Led by @jakob_tr and @quiles_nuria, with @lasa_lab, we show that prophages utilise noncontiguous operons to balance immuni….

Really beautiful work describing the gatekeepers of phage nuclei!.

RT @joeBondyDenomy: The phiKZ jumbo phages build a protein based nucleus to protect their DNA(!), but what do they do before the nucleus is….

RT @mike_tilapia: Our paper on functional discovery of protein degradation and stabilization effectors with proteome-scale induced proximit….

RT @RockLabTB: Ever wonder why drug-resistant Mycobacterium tuberculosis is less fit than drug-susceptible Mtb? And how the bacterium can e….

Check out Marie's first first-author manuscript! .@marie_stoltzfus.

Overexpressers are better at making new memories and using old ones, and they have larger functional arrays than WT cells which are surprisingly forgetful! In the absence of phage, overexpressers fade into the night, but Cas9-dependent mutagenesis continuously regenerates them!.

CRISPR-Cas systems are often repressed in nature. This likely helps bacteria avoid autoimmunity, but what do you do when a phage shows up? We show that a mutant subpopulation of S. pyogenes overexpresses Cas9 and these superpowered cells may do the real CRISPRin’.