Kemal Keseroglu
@KemalKeseroglu
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Research Fellow - Cincinnati Children’s Hospital
Cincinnati, OH
Joined February 2010
Exciting news! Just published in @NatureComms: "Stochastic gene expression and environmental stressors trigger variable somite segmentation phenotypes." #Zebrafish #Genetics #DevelopmentalBiology
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🚨News alert !! Honored to be endowed with Robert Laughlin Rea Professor of Anatomy at Northwestern University!
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@realRihellab @SuppAnya @stevewilsonfish @GarethTPowell @CityUHongKong @AmpatzisLab @jraslab @errricpeterman @JLS_Lab @DvirGur Preprints (cont.): @EngertLab @MishaAhrens @alexbchen (Astroglial purinergic signaling/ Norepinephrine) https://t.co/SvtGM1FWaO
@SeuntjensLab @CarolineZandeck (Killifish/ Telencephalon/ Growth/ Neural diversity) https://t.co/2AfQ8xiOFk
@joachimgoedhart (EzReverse/ Color
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Congratulations @KemalKeseroglu and @OzbudakLab. It was so much fun exploring the role of the genetic oscillators in embryonic development. Thanks @jtchieu for discussions and providing valuable feedback and thanks to Ben Caputo and Brady Cline for critical reading and editing.
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Then, we discuss the gatekeeping role of their oscillatory expression in neurogenesis, myogenesis and pancreas development. It ensures proper embryonic development by regulating proliferation-to-differentiation switch of stem cells and progenitor cells.
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We first summarize our favorite topic, somitogenesis. Describing how the oscillatory expression of Hes/Her genes and their targets is utilized by cells to measure time. Thereby creating periodic pattern of somites in space.
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Hey, Curious minds! Ever wondered how stem cells magically transform into the right cells at the right time? Or how nature creates beautiful patterns like somites? Explore the fascinating world of oscillatory Hes/Her genes in our review! #Science #STEM
Oscillatory control of embryonic development In this Review, Angad Singh Chandel, Kemal Keseroglu & @OzbudakLab explore the diverse functional roles played by the oscillatory expression of bHLH family transcription factor Hes/Her genes and their targets: https://t.co/ps1xxX0has
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Oscillatory control of embryonic development In this Review, Angad Singh Chandel, Kemal Keseroglu & @OzbudakLab explore the diverse functional roles played by the oscillatory expression of bHLH family transcription factor Hes/Her genes and their targets: https://t.co/ps1xxX0has
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2nd paper this year from our lab. Congratulations to @KemalKeseroglu and @OrianaZinani for publishing protocol paper on using single-molecule fluorescence in situ hybridization (#smFISH) and immunohistochemistry to count molecules in single cells in @ZebrafishRock
I am delighted to share our new protocol paper on using single-molecule fluorescence in situ hybridization (#smFISH) and immunohistochemistry (#IHC) to count RNA molecules in single cells in #zebrafish embryos has been published in @STARProtocols
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Read about the ups, downs and eureka moments behind our recently published work @Nature. Thank you @the_Node for this blog.
New on the Node @FethullahSimsek & colleagues from @OzbudakLab share the story behind their research on clocks, gradients and segmentation, where they discover that clock-dependent oscillations in the ppERk gradient drive sequential somite segmentation. https://t.co/CbuFPMh0ZN
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@alevlab and Pourquie ( @YuchuanMiao ) labs recently published 3-D human somitogenesis models @Nature + @sharadramanath1 lab @Cell as well. Our two cents (spotlight @CellStemCell) on how they teach about conserved mechanisms to make somites: https://t.co/c6hoolqOwA
#development
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Tune-in for an amazing talk by @FethullahSimsek this Thursday.
Thursday March 23rd join us to learn how to break symmetry with Harry McNamara, & delve into the mechanisms of sequential segmentation in vertebrates with @FethullahSimsek in the @OzbudakLab! 12:30 PM EDT (note that the US sprung forward 1 hr last weekend⌚️)
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To all the curious minds, talk starts at 12.30 pm EST, please do join it.
Thursday March 23rd join us to learn how to break symmetry with Harry McNamara, & delve into the mechanisms of sequential segmentation in vertebrates with @FethullahSimsek in the @OzbudakLab! 12:30 PM EDT (note that the US sprung forward 1 hr last weekend⌚️)
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A spotlight on recent human stem cells models of somite segmentation from our lab. https://t.co/WZjlJbwOHG
cell.com
In vitro models to study human somitogenesis, the formation of the segmented body plan, have so far been limited.1 Two papers in Nature now report the creation of pluripotent stem cell (PSC)-derived...
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Congratulations to Bibek on becoming Dr. Dulal! Well defended! 🎉
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A review from our lab on the role of FGF Signaling in somitogenesis.
Our review on the role of FGF signaling in somitogenesis is online now. One learns a lot while going through the process of writing a review. I had multiple epiphanies. I strongly recommend trainees and young researchers to write one. https://t.co/sXbgKLbGzG
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Congratulations Muhammed on starting your lab @McMasterU . We are all so proud of you.
1/3 I am happy to announce that I will be moving to Canada to join the faculty of McMaster University @McMasterU. "Physical Biology of Developing Systems" (pBODS) Lab https://t.co/GtcauUyUec will be opening in January 2024 in the Biology Department @biogradmcmaster. +
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Congratulations to @ChandelAngad on winning the poster award 👏🎉
It was fun sharing how nature forms incredible patterns with scientists outside of the field. It's even more rewarding when you can excite judges for your specialized work and receive the 1st place recognition. A big thank you to my department for organizing the retreat.#scicomm
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Exciting news! Just published in @NatureComms: "Stochastic gene expression and environmental stressors trigger variable somite segmentation phenotypes." #Zebrafish #Genetics #DevelopmentalBiology
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