Ozbudak Lab
@OzbudakLab
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Systems Developmental Biology Lab @northwesternU. We study embryonic pattern formation.
Joined December 2022
🚨🚨A review from our lab just came out in @ScienceAdvances. In this review, we critically explore four decades of work on the early stages of spine development. Link: Congrats🎉🥳 @CassieLeduc2 @FethullahSimsek @ChandelAngad .#AcademicTwitter #Science.
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Check out this behind the paper by Eslim Alpay - .Functional Roles of DeltaC and DeltaD in Zebrafish Segmentation Clock: A Novel Positive Feedback in Notch Signaling #.
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Congratulations to @aeslimesra for her first first author paper. Congrats to all the authors @OrianaZinani, Xiyan, Ahmet.
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Exciting new findings from our lab! ⏳🐟.In our latest @NatureComms paper, we show that DeltaD—not just DeltaC—drives Notch signaling in zebrafish, reshaping our understanding of segmentation clock dynamics! 🔬✨ . Paper:
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Join us for this amazing trainee talk by @ChandelAngad.
📣Join us this Tuesday @ 9AM the Baldwin Auditorium for a Trainee Seminar, presented by @ChandelAngad , Predoctoral Fellow in the @OzbudakLab 🧬📚
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RT @NU_BSA: A new study from the @OzbudakLab, published in @Dev_Cell, reveals new details about how the spinal column forms in developing v….
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🎉 Check out the full story here: Dive into how biology’s clockwork mechanisms sculpt life. ⏰🧬🐟.
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🙌 Collaborators:.Congrats to all the authors @FethullahSimsek @didarsaparow @KemalKeseroglu @OrianaZinani @ChandelAngad ,Bibek, Bal Krishan, Soling . Big thanks to our incredible team across @NorthwesternU @NU_CDB, @CincyChildrens,@uofcincy & beyond!.
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🌍 Broader context:.Our findings expand the understanding of how molecular clocks synchronize cellular processes, hinting at similar mechanisms in other developmental and regenerative systems. (5/).
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📊 Why this matters:.This work bridges two major signaling pathways—Her/Hes oscillators and FGF/ERK activity—revealing how their crosstalk ensures precise body patterning. The implications extend to congenital disorders and regenerative medicine. 🧩💡.(4/).
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🛠 Key insights:.1️⃣ Her/Hes proteins regulate Dusps post-translationally—not transcriptionally. 2️⃣ Without these ERK oscillations, somite segmentation fails, disrupting the vertebrate body plan. 3️⃣ Beyond development, this could unlock ERK’s secrets in regeneration! 🧬.(3/).
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🔬 What we found:.Her/Hes proteins—oscillatory transcription factors—directly interact with Dusp4 & Dusp6, stabilizing these phosphatases. This stabilization drives ERK activity oscillations, which in turn, govern somite segmentation. (2/).
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🌟 New Paper Alert! 🚨.How does a developing embryo know where to place somite boundaries? 🦴🐟.Our latest study in @Dev_Cell reveals a missing piece of the puzzle involving ERK oscillations and the segmentation clock (.(1/)
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🚨News alert !! Honored to be endowed with Robert Laughlin Rea Professor of Anatomy at Northwestern University!
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RT @NU_CDB: 📣Thrilled to announce the new postdoctoral & predoctoral departmental representatives: Bhuvan, Postdoctoral Fellow in the Gelfa….
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In this review, we discuss a plethora of models including the #ClockAndWavefront, #CellCycle, #reaction-diffusion, #phase-shift model along with a newly proposed model from our lab clock-dependent oscillatory gradient (COG) model. #morphogenesis#devbio @ZebrafishRock.
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