Ozbudak Lab
@OzbudakLab
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Systems Developmental Biology Lab @northwesternU. We study embryonic pattern formation.
Joined December 2022
🚨🚨A review from our lab just came out in @ScienceAdvances. In this review, we critically explore four decades of work on the early stages of spine development. Link: https://t.co/tXb0JGBcZL Congrats🎉🥳 @CassieLeduc2 @FethullahSimsek @ChandelAngad
#AcademicTwitter #Science
science.org
A comprehensive review explores models, data, and outstanding questions in the field of vertebrate somite segmentation.
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Celebrating @aeslimesra paper getting published https://t.co/CWwlrnnRAs
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Check out this behind the paper by Eslim Alpay - Functional Roles of DeltaC and DeltaD in Zebrafish Segmentation Clock: A Novel Positive Feedback in Notch Signaling https://t.co/M2g8uZ1UQD #
communities.springernature.com
Our findings show that, despite previously reported as non-functional, DeltaD homodimers are functional and indispensable during zebrafish somitogenesis along with the DeltaC dimers. In addition, we...
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Congratulations to @aeslimesra for her first first author paper. Congrats to all the authors @OrianaZinani, Xiyan, Ahmet.
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Exciting new findings from our lab! ⏳🐟 In our latest @NatureComms paper, we show that DeltaD—not just DeltaC—drives Notch signaling in zebrafish, reshaping our understanding of segmentation clock dynamics! 🔬✨ Paper:
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Join us for this amazing trainee talk by @ChandelAngad
📣Join us this Tuesday @ 9AM the Baldwin Auditorium for a Trainee Seminar, presented by @ChandelAngad , Predoctoral Fellow in the @OzbudakLab 🧬📚
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A new study from the @OzbudakLab, published in @Dev_Cell, reveals new details about how the spinal column forms in developing vertebrates. https://t.co/PYCY88tP4p
news.feinberg.northwestern.edu
Northwestern Medicine scientists have uncovered new details about how the spinal column forms in developing vertebrates, according to a study published in Developmental Cell.
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🎉 Check out the full story here: https://t.co/3o3DLKI4do Dive into how biology’s clockwork mechanisms sculpt life. ⏰🧬🐟
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🙌 Collaborators: Congrats to all the authors @FethullahSimsek @didarsaparow @KemalKeseroglu @OrianaZinani @ChandelAngad ,Bibek, Bal Krishan, Soling . Big thanks to our incredible team across @NorthwesternU @NU_CDB, @CincyChildrens,@uofcincy & beyond!
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🌍 Broader context: Our findings expand the understanding of how molecular clocks synchronize cellular processes, hinting at similar mechanisms in other developmental and regenerative systems. (5/)
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📊 Why this matters: This work bridges two major signaling pathways—Her/Hes oscillators and FGF/ERK activity—revealing how their crosstalk ensures precise body patterning. The implications extend to congenital disorders and regenerative medicine. 🧩💡 (4/)
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🛠 Key insights: 1️⃣ Her/Hes proteins regulate Dusps post-translationally—not transcriptionally. 2️⃣ Without these ERK oscillations, somite segmentation fails, disrupting the vertebrate body plan. 3️⃣ Beyond development, this could unlock ERK’s secrets in regeneration! 🧬 (3/)
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🔬 What we found: Her/Hes proteins—oscillatory transcription factors—directly interact with Dusp4 & Dusp6, stabilizing these phosphatases. This stabilization drives ERK activity oscillations, which in turn, govern somite segmentation. (2/)
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🌟 New Paper Alert! 🚨 How does a developing embryo know where to place somite boundaries? 🦴🐟 Our latest study https://t.co/3o3DLKI4do in @Dev_Cell reveals a missing piece of the puzzle involving ERK oscillations and the segmentation clock ( https://t.co/RHVJiRP4at) (1/)
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🚨News alert !! Honored to be endowed with Robert Laughlin Rea Professor of Anatomy at Northwestern University!
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