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Florian Engert Profile
Florian Engert

@EngertLab

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Harvard University
Joined July 2015
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@EngertLab
Florian Engert
5 months
RT @bdanubius: How much do we *really* learn?. In @NatRevNeurosci with @EngertLab and @AFerreiraCastro, we address why most of you humans f….
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@EngertLab
Florian Engert
11 months
This mechanistic reductionist approach allows us now to make explicit predictions about the underlying neural circuits in the visuomotor processing stream, and thereby guide future whole-brain imaging and neural recording experiments to get at the underlying neural circuits.
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@EngertLab
Florian Engert
11 months
This modeling framework accurately captures our behavior findings, and allows us to make novel behavioral predictions that we confirm in subsequent experiments.
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@EngertLab
Florian Engert
11 months
Based on these experimental findings we generate a time-varying state space model that links the history of visual stimulation to the strength of inter-individual interactions, thereby providing a quantitative, predictive, framework for the modulation of collective behavior.
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@EngertLab
Florian Engert
11 months
Remarkably, it is not translational motion, as reflected by other fish passing by, but it is - very specifically - looming stimuli, as induced by neighbors approaching, that is critical for changing the internal state of the animals.
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@EngertLab
Florian Engert
11 months
We precisely measure the time dynamics of these modulations and find that they develop slowly over tens of minutes and remain stable for many hours. Notably, we have isolated the specific visual features of neighbors swimming in the vicinity that induce the modulation.
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@EngertLab
Florian Engert
11 months
We find that already at a very young age (7 days post fertilization), previously experienced social densities strongly modify the current collective behavior of the larvae: experience with high social densities decreases the vigor of inter-individual responses and vice versa.
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@EngertLab
Florian Engert
11 months
In the new project we used, in a very similar fashion, naturalistic and virtual reality experiments and computational analysis to study how the history of experienced social environments modifies these individual-level computations and changes the resulting collective behaviors.
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@EngertLab
Florian Engert
11 months
It is an extension of a previous story where we have described the precise visuomotor transformations that underlie collective behaviors in these small and amazing animals (Harpaz et al,. 2021 Nat Comm).
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@EngertLab
Florian Engert
11 months
The story is entitled.Experience-dependent modulation of collective behavior in larval zebrafish.
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@EngertLab
Florian Engert
11 months
Check out the latest project that came out of the phenomenally productive collaboration that Roy Harpaz (@RoyHarpaz) has initiated a few years ago by bridging the joint expertises of @engertlab and the team of Mark Fishman (also here at Harvard).
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@EngertLab
Florian Engert
1 year
RT @MCB_Harvard: Nature Over Nurture: Functional Neuronal Circuits Emerge in the Absence of Developmental Activity [Engert Lab] @EngertLab….
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@EngertLab
Florian Engert
1 year
RT @bdanubius: Now out in @NatureComms, our paper on activity- and experience- independent maturation of sensorimotor behaviors in zebrafis….
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@EngertLab
Florian Engert
1 year
RT @lpachter: This has become one of my favorite papers. We're very VERY far away from understanding how the brain works. .
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@EngertLab
Florian Engert
2 years
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@EngertLab
Florian Engert
2 years
RT @DulacLab: I got very interesting colleagues @harvardbrainsci and.@MCB_Harvard 🤣🤣. Good luck @EngertLab and @BOlveczky in your crazy sai….
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@EngertLab
Florian Engert
2 years
The true star and hero of the story is Kumaresh Krishnan who defended his PhD recently with this project and a few others of similar impact and excitement 😁😁.
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@EngertLab
Florian Engert
2 years
while ‘competence’ is influenced mainly by the environment in which fish are raised. A link to a preprint copy is here.
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@EngertLab
Florian Engert
2 years
Another really remarkable finding that emerged when we used our assay to dissect the consequences of specific environmental and genetic perturbations, is that the extent of ‘focus’ is largely inherited from the parents,.
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@EngertLab
Florian Engert
2 years
This is cool, because it resonates with an explanation for a failure to perform also in humans: we can either be not focused, or just not very good at a task if our performance is lacking.
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