The Rihel lab
@realRihellab
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Zebrafish lab @UCL. We study the genes & neurons that regulate sleep 🐟💤
Joined March 2019
As reigning Greater London Chess Club champion, Prof Rihel takes on 14 club players at once. Final score- 8 wins, 3 draws, and 3 losses against a tough group!
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Applications now open! Join the SWC PhD Programme 2025 🧠 World-class training in systems neuroscience 💰 Fully-funded 4-year programme 💂 Based in London with close links to @GatsbyUCL Learn more and apply by 11 Nov: https://t.co/8g0atYhP2g
#PhD #Neuroscience
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Check out our preprint on new recombinant tools for reversibly ablating excitatory and inhibitory synapses. https://t.co/SPUvz4vwAw Thanks to amazing first author @AidaBareghamyan and collaborators @RichKramerLab , Dave Chenoweth and Robert Campbell.
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Excited to post a new preprint, work by @T___Kawashima, @zq_wei and collaborators: Voltage imaging reveals circuit computations in the raphe underlying serotonin-mediated motor vigor learning https://t.co/IHzsx0z4AF
biorxiv.org
As animals adapt to new situations, neuromodulation is a potent way to alter behavior, yet mechanisms by which neuromodulatory nuclei compute during behavior are underexplored. The serotonergic raphe...
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Confusing stuff. Influx isn't efflux (clearance). Is it less gets in during waking or simply more on net gets out? Also, per intro, more Abeta is *secreted* during sleep deprivation, so its accumulation says little about clearance.
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Very happy to have Boston Children's Hospital cover our recent Science paper on macrophages quality assuring stem cells by sensing ROS (dooming) or endogenous viral elements (grooming). This discusses our future plans.
answers.childrenshospital.org
Scientists find the signals that tell macrophages to eliminate diseased blood stem cells, a new strategy for fighting blood cancers.
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I recently gave a talk on: Nonlinearity and network topology in multimodal circuits. Which you can watch here: https://t.co/BpAdDS9tr3
And here's the one from @MarcusGhosh
https://t.co/uT5A6Zr0Ej Some impressive work is being done by a very cool team, join them.
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Whoa!
Incredibly proud to share this work, almost 6 years in the making, out in @ScienceMagazine!!! 🎇 We've known for over a century that eukaryotes of all kinds anticipate the seasons (think: hibernation, flowering, reproduction), but what about bacteria?🦠 https://t.co/I9vw5ZTKbT
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I loved the website 1 million checkboxes. And now I am even more pleased to see what the nerds were doing with the site. Incredible!
eieio.games
Teens wrote me a secret. I found them.
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Re: sperm shipping rules, this will obviously vary from country to country, so there are still some practical issues that you would need to work out on the shipping/receiving end. But our experience so far is MUCH less paperwork and like 2 orders of magnitude cheaper.
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We've modded/interpreted the original paper's protocol slightly. Happy to share what we've done.
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We've tested this ourselves and it works brilliantly. >80% fertilization rates after 7 days+ at RT. We've now managed to ship fishes (as sperm) internationally for like 70 pounds overnight shipping costs. Enormous time and money saver!
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Zebrafish peeps: I understand after many conversations at the Kyoto meeting that not everyone is aware of the Room Temperature zebrafish sperm paper. In Vitro Storage of Functional Sperm at Room Temperature in Zebrafish and Medaka | Zebrafish ( https://t.co/yDq3IhByHF)
liebertpub.com
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Congrats @stevewilsonfish ! Such well deserved recognition …
Steve Wilson receives the Christiane Nüsslein-Volhard Award for outstanding achievements in genetics research using zebrafish as a model system at the IZFS meeting in Kyoto. Fantastic recognition of his contributions to the Zebrafish community and research achievements. #IZFS
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For those who aren’t at #IZFC2024 in Kyoto or want to know more, Gaia, Kate, and I wrote a little piece for @the_Node earlier this year.
thenode.biologists.com
Within our collective of zebrafish labs at UCL, the sheer volume of single-use plastic Petri dishes we breeze through is staggering - a staggering 130 kg
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Although I’m physically just across the Korean Strait and not there, come check out our poster on #Sustainability in 🐟🔬research poster no 111 #IZFC2024 @stevewilsonlab @realRihellab
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Cassandra Extavour is the first Black woman to win tenure in the biological sciences at Harvard. She’s also a classically trained soprano. https://t.co/ODNWs6VMXO
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Sleep maintains excitatory synapse diversity in the cortex and hippocampus: Current Biology
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We are excited to share our latest work: https://t.co/gtwt0MsoN0 in which we show that local DNA compaction creates TF-DNA clusters that enable transcription.
biorxiv.org
Transcription factor (TF) clusters have been suggested to facilitate transcription. The mechanisms driving the formation of TF clusters and their impact on transcription, however, remain largely...
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New work from the #WeinsteinLab is on biorxiv! With MAJOR help from @ZebrafishMK and @aurora_kraus : The axillary lymphoid organ - an external, experimentally accessible immune organ in the zebrafish. Tweetorial below. #Zebrafish
https://t.co/naiDHeQP6B
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