Kathryn Beabout
@KathrynBeabout
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Joined May 2009
Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —outgrowth of decades of NIH funded research https://t.co/XHntu0xNIZ
https://t.co/XhpAn16HaI
@NEJM
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Check our most recent review led by @erayubozkurt w/ Emil, @Daniel__Volke and @PabloINik on Accelerating enzyme discovery and engineering with high-throughput screening A must read for protein engineering & automation fans! https://t.co/HOpPbOTzki 🧵👇
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How can we more rapidly develop cell-free biosensors for the detection of chemical compounds such as toxins and human health biomarkers? @LucksLab @akarimlab @NUSynBio
https://t.co/oE6rN4QawS
biorxiv.org
Cell-free synthetic biology biosensors have potential as effective in vitro diagnostic technologies for the detection of chemical compounds such as toxins and human health biomarkers. They have...
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Follow along with us today as we feature hot-off-the-press customer papers! First up: “A frugal CRISPR kit for equitable and accessible education in gene editing and synthetic biology”
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Imagine bacteria mining cryptocurrencies. We moved a step closer by encoding a 2-bit MD5 cryptographic hash algorithm – a precursor of SH256 used for Bitcoin - across 66 E. coli strains. It required over 1 megabase of DNA, the size of a small genome. https://t.co/CyjhE88JwZ
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Looking for educational kits for #syntheticbiology ? Check out this new frugal #cellfree kit for learning about CRISPR with @stanleyqilab @NatureComms
nature.com
Nature Communications - Equitable and accessible education in life sciences, bioengineering, and synthetic biology is crucial for training the next generation of scientists. Here the authors...
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What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
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Our preprint on engineered bacterial microlenses is out! We engineered bacteria to display sea sponge enzymes on their outer membranes. These bacteria can self-assemble a bioglass coating around themselves, and focus light into bright, photonic nanojets. https://t.co/FOgDLnnxKF
biorxiv.org
Photonic devices are cutting-edge optical materials that produce narrow, intense beams of light, but their synthesis typically requires toxic, complex methodology. Here we employ a synthetic biology...
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Many therapeutic proteins require #glycosylation for function. How can we advance #biomanufacturing of human-like glycans on proteins? @MaddieDeWinter Derek Wong, Ariel Thames @mattdelisa @WKightlinger report new strategies in @ACSPublications
https://t.co/O5PBpakFMZ
pubs.acs.org
N-linked glycosylation plays a key role in the efficacy of many therapeutic proteins. One limitation to the bacterial glycoengineering of human N-linked glycans is the difficulty of installing a...
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We're very excited to share that our paper on the 21-dehydroxylation of steroids is online in @CellCellPress today! Read how flatulence drives bacterial production of allopregnanolone, an FDA-approved drug for postpartum depression. Full-text here: https://t.co/Zh7KvjZkf8
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In vitro transcription-based biosensing of glycolate for prototyping of a complex enzyme cascade https://t.co/NqvDiz7Qh0
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What's better than #cellfree #syntheticbiology? #cellfree #syntheticbiology in space! 🚀🛰️ !!! Our new collaborative work with @kocalars @miniPCR @genesinspace @Boeing @ISS_CASIS @allyquot building off innovations from @JessicaCStark + more https://t.co/nXThfM450s
pubs.acs.org
Cell-free protein synthesis (CFPS) is a rapidly maturing in vitro gene expression platform that can be used to transcribe and translate nucleic acids at the point of need, enabling on-demand synthe...
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#ProudCareerMoment: I've been working on this project since initial conception over two years ago and it's incredibly fulfilling to see it coming to fruition. We welcome our first set of campers tomorrow!
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Incoherent merger network for robust ratiometric gene expression response
academic.oup.com
Abstract. A ratiometric response gives an output that is proportional to the ratio between the magnitudes of two inputs. Ratio computation has been observe
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Indirect Enrichment of Desirable, but Less Fit Phenotypes, from a Synthetic Microbial Community Using Microdroplet Confinement
pubs.acs.org
Spatial structure within microbial communities can provide nearly limitless opportunities for social interactions and are an important driver for evolution. As metabolites are often molecular...
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How long is your cell-free #synbio extract stable for? In @ACSSynBio, Blake Rasor @smashty @LabAlper assessed activity of metabolism in yeast and bacterial extracts during storage for 18 months. The punchline - they are stable. #funded by @doescience @jgi
https://t.co/8VyCvNh0rB
pubs.acs.org
Cell-free synthetic biology enables rapid prototyping of biological parts and synthesis of proteins or metabolites in the absence of cell growth constraints. Cell-free systems are frequently made...
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Over the past 6-8 years, our lab (Murray lab at @Caltech) has worked on developing modeling tools for synthetic biological circuits. Three of these tools are in great shape now and ready for wide applications. One such application is an automated learn+predict pipeline: 1/ 🧵
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What's in your extract? Cell-free systems from crude cell-extracts are used in manufacturing, sensing, and education. We wondered how extract processing impacts the protein and metabolic activity. Check it out 👇 @ORNL @NUSynBio Funded by @doescience
https://t.co/C3hJNdoU8d
pubs.acs.org
Cell-free systems derived from crude cell extracts have developed into tools for gene expression, with applications in prototyping, biosensing, and protein production. Key to the development of these...
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