Weston Kightlinger
@WKightlinger
Followers
135
Following
16
Media
2
Statuses
31
Scientist and founder using cell-free and other biomanufacturing technologies to improve medicine | @NorthwesternEng PhD | @Swiftscalebio | Resilience
San Francisco, CA
Joined April 2012
We're looking for a Glycoengineering Scientist to join our team. If you or anyone you know loves all things #glycoproteins #glycosylation #glycotime #glycoscience #glycans please reach out to help buildout an emerging platform and accelerate therapeutics manufacturing! #hiring
0
19
29
Thanks Ben!
@claudiaevickers @WKightlinger @ACSSynBio @jewettlab_NU @ktwarfel @DeLisaGroup @mattdelisa Fantastic review Weston and co!
0
0
1
0
0
1
How sweet it is. Our new review on synthetic glycobiology for the #synbio audience is out. @WKightlinger @ktwarfel @mattdelisa @NUSynBio describe recent innovations and #glycotime applications, from manufacturing medicines to materials. #bioeconomy
https://t.co/rvp7F8gEEK
0
12
59
Our Synthetic Glycobiology review is @ACSSynBio! Whether you're a glycobiology purist or a synbio gene wrangler, make it your go-to review for all the exciting things bridging #glycotime and #synbio! Thanks @jewettlab_NU @ktwarfel @DeLisaGroup @mattdelisa! https://t.co/GymD6xWQED
pubs.acs.org
Protein glycosylation, the attachment of sugars to amino acid side chains, can endow proteins with a wide variety of properties of great interest to the engineering biology community. However,...
2
11
35
Check out #ASAP research by Michael C. Jewett @jewettlab_NU, Milan Mrksich & team @NUSynBio on sequential glycosylation of proteins with substrate-specific N-Glycosyltransferases: https://t.co/bsz5j4Wj2G
0
3
10
Check out our latest paper with Liang Lin @mrksich with a creative way to create defined glycoproteins in vitro! We discovered new enzyme specificities to install multiple unique glycans on a single target protein. @jewettlab_NU @NUSynBio #glycotime
pubs.acs.org
Protein glycosylation is a common post-translational modification that influences the functions and properties of proteins. Despite advances in methods to produce defined glycoproteins by chemoenzy...
0
10
31
COMET - a platform for composing gene expression for mammalian synthetic biology - is out today! @NatureComms https://t.co/2a8WzKEDKb
1
34
98
0
0
5
Excited to share my latest paper with Jose Marc Techner that was just accepted at Analytical Chemistry! We provide a high-throughput way to synthesize and analyze intact glycoproteins using CFPS and SAMDI-MS. https://t.co/PXENSXWCpV
@jewettlab_NU @DeLisaGroup @mrksich @NUSynBio
pubs.acs.org
High-throughput quantification of the post-translational modification of many individual protein samples is challenging with current label-based methods. This paper demonstrates an efficient method...
1
3
13
@WKightlinger @Stjle @PardeeLab @ozalabCP jewettlab @NUSynBio reuinion at the cell freesystems19 conference
0
3
21
Had an amazing time at the Cell-Free Systems conference in Boston this week connecting with the fantastic people in the community.
@WKightlinger @Stjle @PardeeLab @ozalabCP jewettlab @NUSynBio reuinion at the cell freesystems19 conference
0
1
13
#Cellfree #SyntheticBiology Comes of Age: Cell-free systems stand to dramatically impact society, from the environment to medicine to education https://t.co/WRpCQVqjuQ
#synbio @jewettlab_NU
1
9
17
New Method Accelerates Development of Protein #Therapeutics: Cell-free system allows researchers to quickly find new pathways https://t.co/3EydSNkMFk
#synbio @jewettlab_NU
mccormick.northwestern.edu
Northwestern Engineering researchers have developed a quick, cell-free system to create biosynthetic pathways to build and study sugar structures.
0
6
15
.@jewettlab_NU, @mattdelisa, and @NUSynBio build GlycoPRIME for constructing protein glycoslyation pathways https://t.co/dvX3wqSnoS Out now @NatureComms
0
2
7
.@jewettlab_NU, @NUSynBio provide us with guidelines on expanding the genetic code using flexizymes https://t.co/iEJ8c2V4si Out now @NatureComms
nature.com
Nature Communications - Flexizymes have been used to expand the scope of chemical substrates for ribosome-directed polymerization in vitro. Here the authors deduce design rules of...
0
3
10
Cell-free systems are enabling on-demand biomanufacturing, portable diagnostics, and next-generation educational kits. Read about how cell-free systems have come of age with @smashty @NUSynBio @adsilverman627 Thanks to all who helped with this and for the opportunity to write it
Cell-free gene expression: an expanded repertoire of applications https://t.co/giRlA7ykiL
#Review by Adam D. Silverman, Ashty S. Karim & Michael C. Jewett (@jewettlab_NU)
0
16
51
Great write-up by @NorthwesternEng and @NorthwesternU on our GlycoPRIME paper! “The dream is to create new-to-nature glycoproteins that could be made on-demand to develop new types of protein medicines.” @jewettlab_NU
mccormick.northwestern.edu
Northwestern Engineering researchers have developed a quick, cell-free system to create biosynthetic pathways to build and study sugar structures.
0
2
4
@jewettlab_NU @NUSynBio Fantastic job and huge thank you to my coauthors @JessicaCStark @mattdelisa @_aravindnat and @DeLisaGroup @mrksich and more!
0
0
0
It's GlycoPRIME for #glycotime. Check to this news story on our new method for constructing biosynthetic pathways to study and engineer precise glycan structures on proteins. @WKightlinger @JessicaCStark @DeLisaGroup @mattdelisa @_AravindNat and more. https://t.co/TSuWdFdKXb
nature.com
Nature Communications - Constructing biosynthetic pathways to study and engineer glycoprotein structures is difficult. Here, the authors use GlycoPRIME, a cell-free workflow for mixing-and-matching...
Researchers in Northwestern's Center for Synthetic Biology have developed a new cell-free system to build and study biosynthetic pathways. The system could lead to a modular way to make medicines on demand in resource-limited settings. https://t.co/LxL1lt3i4A
@jewettlab_NU
0
4
10