Matthew DeLisa
@mattdelisa
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Cornell chem & bio engineering professor, bike racer and dad
Ithaca, NY
Joined March 2009
Glycosylation of Structured Protein Domains in Cell-Free Reaction Environments | ACS Synthetic Biology
pubs.acs.org
The production of N-linked glycoproteins in genetically tractable bacterial hosts and their cell-free extracts holds great promise for low-cost, customizable, and distributed biomanufacturing of...
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Intracellular delivery of full-length antibodies via organ targeted lipid nanoparticles https://t.co/VXTMY97WWZ
#biorxiv_bioeng
biorxiv.org
Antibodies are proteins prized for their ability to bind to extracellular antigens with exceptionally high affinities and specificities. These features have motivated researchers to utilize antibod...
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My PhD work is out in @NatureComms !โจFor the first time, we show that bacteria can glycosylate full-length monoclonal antibodies. A proof of concept and a key step toward making antibody therapies accessible to all.. https://t.co/TfOOutnNtv
#biotech #glycotime #SyntheticBiology
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Study led by @Cornell sets the stage for using E. coli to produce fully human antibodies! Read the full paper here ๐ https://t.co/WuL53j7sb8
https://t.co/WuL53j7sb8
nature.com
Nature Communications - Glycosylation of human IgG antibodies in bacterial hosts has proven challenging. Here, the authors identify a bacterial enzyme enabling E. coli to glycosylate IgGs at native...
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Target sequence-conditioned design of peptide binders using masked language modeling https://t.co/es8TEjrVTL
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PepMLM is out in @NatureBiotech! ๐ญWant a short binder for any target? Just input its sequence + desired binder length โ PepMLM unmasks it. Simple? No way? The results speak for themselves. ๐ ๐: https://t.co/RRZwQe82tu ๐ป: https://t.co/8l3nSNEtHo ๐ค: https://t.co/9aSfxzZZTo
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Antibodies are important therapeutics, but producing them in bacteria has been difficult due to glycosylation. w/ @mattdelisa @BelenSotomayor5 we discovered an enzyme that can glycosylate the native Fc acceptor sequence. Pretty cool. @NatureComms
https://t.co/V87U62C2G6
nature.com
Nature Communications - Glycosylation of human IgG antibodies in bacterial hosts has proven challenging. Here, the authors identify a bacterial enzyme enabling E. coli to glycosylate IgGs at native...
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Congratulations to @BelenSotomayor5 on receiving the Dr. Matilde Hidalgo de Prรณcel Medal, one of Ecuadorโs highest honors! This award recognizes her contributions to science and highlights the innovative research happening in our lab #news
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Congratulations to @BelenSotomayor5 for winning Merckโs Best Oral Presentation Award ๐ฅ and to Deepali for wining Corningโs Best Poster Presentation Award๐ฅ at the CBE Graduate Symposium! Delisa Lab is on fire, keep shining, team! #science
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Congratulations to @BelenSotomayor5 on receiving the Spring ๐๐๐๐ ๐๐ฎ๐ฌ๐ญ๐ข๐ง ๐๐จ๐จ๐๐ฒ ๐๐ซ๐๐๐ฎ๐๐ญ๐ ๐๐๐ฌ๐๐๐ซ๐๐ก ๐๐ฑ๐๐๐ฅ๐ฅ๐๐ง๐๐ ๐๐ฐ๐๐ซ๐, the highest honor awarded to a graduate student by @Cornellโs CBE Department!
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Congratulations to @BelenSotomayor5 on her induction into the ๐๐จ๐ฎ๐๐ก๐๐ญ ๐๐ซ๐๐๐ฎ๐๐ญ๐ ๐๐จ๐ง๐จ๐ซ ๐๐จ๐๐ข๐๐ญ๐ฒ at @Yale as one of the @Cornell representatives! Her leadership, scholarship, character, service, and advocacy embody this prestigious honor #STEM #Leadership
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What if bacteria could glycosylate full-length human IgG antibodies at their native site? In our new @NatureComms paper, we discovered an OST enzyme that enables E. coli to do just that for the first time. @BelenSotomayor5 @mattdelisa
https://t.co/OqMBUXeheq
#glycotime #biotech
nature.com
Nature Communications - Glycosylation of human IgG antibodies in bacterial hosts has proven challenging. Here, the authors identify a bacterial enzyme enabling E. coli to glycosylate IgGs at native...
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I'm usually not too emotional about paper acceptances, but this one justifies it. ๐ฅน It doesn't feel real, but PepPrCLIP is now published at @ScienceAdvances! Let me tell you its story. ๐ ๐: https://t.co/A9RbhEMgZB ๐ป: https://t.co/R3nVWnbyNe PepPrCLIP (๐ถ๏ธ๐) began as
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Exciting news from the lab! ๐ We have updated PepMLM on the @arxiv with new computational and experimental benchmarking results! ๐ฅณ Just as a reminder: we trained PepMLM via a novel span masking strategy that positions peptide binder sequences at the C-terminus of their target
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In our latest paper, we've discovered a new PglB enzyme that enables glycosylation of hinge-Fc and full-length IgGsโmarking the first instance of full-length IgG glycosylation in bacteria Check out more here: https://t.co/RJhc5Q9Lk5
#BioTech #glycotime #bacteria
biorxiv.org
Human immunoglobulin G (IgG) antibodies are one of the most important classes of biotherapeutic agents and undergo glycosylation at the conserved N297 site in the CH2 domain, which is critical for...
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Many therapeutic proteins require #glycosylation for function. How can we advance #biomanufacturing of human-like glycans on proteins? @MaddieDeWinter Derek Wong, Ariel Thames @mattdelisa @WKightlinger report new strategies in @ACSPublications
https://t.co/O5PBpakFMZ
pubs.acs.org
N-linked glycosylation plays a key role in the efficacy of many therapeutic proteins. One limitation to the bacterial glycoengineering of human N-linked glycans is the difficulty of installing a...
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A bioconjugation-based approach to remodel protein surface charges using novel anionic tags allows for the functional delivery of proteins using lipid-based nanoparticle carriers NEW #ASAP by @alabiac @mattdelisa & colleagues @CornellChem Read it here: https://t.co/H5hAAcwphH
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Matt DeLisa, Christopher Alabi et al @Cornell investigated a reversible bioconjugation method to alter the surface charge of protein cargos in LNPs, employing an anionic "cloak." This approach aimed to enhance electrostatic complexation of LNP formulations https://t.co/ZKHNuT9h1J
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We are happy to finally recognize our 2023 Marvin J. Johnson Award in Microbial and Biochemical Technology winner @mattdelisa here in New Orleans! Congratulations Matt!
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Bio-orthogonal Glycan Imaging of Culture Cells and Whole Animal C. elegans with Expansion Microscopy https://t.co/DeGZGCfkhz
#biorxiv_bioE
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