Hsp90 Chaperone Machine
@Hsp90Machine
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Joined October 2018
Fantastic meeting -- thanks @CNIOStopCancer (and Paul Workman, @FrydmanLab, @GabrielaChiosis, @NabilDjouder, & @LlorcaLab) for the invitation & hospitality, and to everyone for the great science!
Ends the #CNIOStopCancer-@CaixaResearch Frontiers Meeting Molecular chaperones in cancer and protein quality control, #CFM_MolChaperones. Thank you all for coming!👏
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Excited to see this out having contributed to the work with @TroemelEmily lab! It expands on our previous paper @PLOSBiology showing that knockdown of Hsp90 in the intestine promotes thermotolerance #Hsp90
CUL-6/cullin ubiquitin ligase-mediated degradation of HSP-90 by intestinal lysosomes promotes thermotolerance
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Can computation help understand biology? We discuss it in this paper. @elsbiomedchem @COSB_CRSB @unipv #compchem #machinelearning #drugdesign Structures, dynamics, complexes, and functions: From classic computati...
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Check out our new review from our lab (@mochigianna and others) on the regulation of mitochondrial chaperone function @ChaperoneCode @Hsp90Machine in @StressCell!
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Elegant study by @DerbyLabDuke and Haystead Lab on selective targeting Hsp90 in Malaria!
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Chaperones are TRENDy! Our new review on the specific molecules that target TRAP1 as promising leads for drawing innovative therapeutic strategies https://t.co/za5fohcZQY
@TrendsinPharma @arasola @eli_moroni
@cnr_scitec @lab_colombo @carlossm_82
@Hsp90Machine @ChaperoneCode
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Congratulations to a fantastic @UrologyUpstate @UpstateUroRes resident Dr Nathan Nahhas on an excellent presentation of results from his research rotation in my lab at @InnovateUpstate @UpstateNews Beyond the Doctorate Day!
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Yay, so happy to see this out! Congratulations on a beautiful, thorough mechanistic study, @KravatsLab @ysarfowah and team 👏🏽👏🏽👏🏽
Congrats to @ysarfowah @KravatsLab and co-authors for uncovering important structural transitions in the chaperone activities of Grp94 (aka gp96, endoplasmin, ERp99, Hsp90b1). Honored to play a small role here. https://t.co/ttwZcYcZST
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Congrats to @ysarfowah @KravatsLab and co-authors for uncovering important structural transitions in the chaperone activities of Grp94 (aka gp96, endoplasmin, ERp99, Hsp90b1). Honored to play a small role here. https://t.co/ttwZcYcZST
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The HSP90 chaperone code regulates the crosstalk between proteostasis and autophagy
tandfonline.com
Proteostasis, the maintenance of proper protein folding, stability, and degradation within cells, is fundamental for cellular function. Two key players in this intricate cellular process are macroa...
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💥 Happy to announce new publication on Hsp90/Hsp70 complexes! Great work from @lab_colombo and collab with @sofiaol43489629! How distinct ligand-states lead to unique functional profiles at different chaperone folding stages. #compchem #chaperone #HSP90
https://t.co/G0iJxgdwPI
onlinelibrary.wiley.com
Molecular chaperones, a family of proteins of which Hsp90 and Hsp70 are integral members, form an essential machinery to maintain healthy proteomes by controlling the folding and activation of a...
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Ever wonder how too much or too little #sugar leads to #disease? https://t.co/pcW6kxCClm
https://t.co/9B4rDasGUt
@MDPIOpenAccess from @chiosislabmskcc @MSKCancerCenter @lab_colombo #Research #HealthScience #Covid_19 #Cancer #Neurology
mdpi.com
Glycosylation, a prevalent post-translational modification, plays a pivotal role in regulating intricate cellular processes by covalently attaching glycans to macromolecules. Dysregulated glycosyla...
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📢 The Call for Applications for our 2024 Early Career Fellowships is now OPEN! If you're a woman scientist in a developing country, don't miss this opportunity for funding that lets you do your own research, without leaving home. All info @ https://t.co/ltsjopjgNl
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Join us for tomorrow’s Hsp90 webinar! John Catravas: Hsp90 inhibitors in pre-clinical models of acute and chronic pulmonary pathologies.
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I love it!! You two have inspired me!!!
Hsp70-Hsp90 complex seen in the wild today at UNC Charlotte 🔥🔥🔥 @unccharlotte @UNCCBiology with @HawleLab #chaperones #proteostasis #hsp70 #hsp90
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I love it!!! Now all we need is some Co-chaperones🤣🤣
Hsp70-Hsp90 complex seen in the wild today at UNC Charlotte 🔥🔥🔥 @unccharlotte @UNCCBiology with @HawleLab #chaperones #proteostasis #hsp70 #hsp90
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Hsp70-Hsp90 complex seen in the wild today at UNC Charlotte 🔥🔥🔥 @unccharlotte @UNCCBiology with @HawleLab #chaperones #proteostasis #hsp70 #hsp90
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Our next Hsp90 webinar is on Monday Dec4, with Marco Prado @maximoprado presenting on the Hsp90 chaperone machinery in neurodegenerative diseases. 12pm EST/6pm CET. Excited to hear this talk🌟Find out more on
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📢In recognition of his fundamental contributions to #ProteinStructure formation and the role of #chaperones, Prof. Johannes Buchner @buchnerlab_tum @TU_Muenchen will be awarded the #OttoWarburgMedal 2024 of the GBM and its sponsors @ElsevierConnect and @BBAjournals🏅Congrats🎉
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