We are so grateful to our structural biology community for helping us grow Current Research in Structural Biology for the past 2 years, shaping it into a great place to publish, raise visibility of all your structural biology research! https://t.co/wEGqfBXGzI

Deep learning is reshaping how we predict protein disorder. This COSB review covers cutting-edge methods and how community efforts are advancing the field. 🔗 https://t.co/phz8DAmGBm #proteinDisorder #deeplearning #COSB

Genotype to Phenotype: Bridging Biochemistry & Genetics. How do variants lead to disease? This COSB review blends genetics and biochemistry to decode the path from genotype to complex phenotype. 🔗 https://t.co/PC3iuWrvDl #genomics #biochemistry #COSB

From mRNA vaccines to Paxlovid: the Protein Data Bank was key to COVID-19 drug and vaccine design. Read how structural data saved lives. 🔗 https://t.co/vnZOSLgMBK #COVID19 #PDB #structuralbiology

How do disordered regions evolve to fine-tune protein interactions? This COSB review applies an evolutionary lens to the folding-upon-binding process. 🔗

Protein language models (pLMs) are redefining structure prediction, capturing the “grammar of life” directly from sequences and often outperforming MSA-based methods with fewer resources. 🔗

Residue Interaction Networks reveal the logic behind protein structure and evolution. This review showcases how graph theory guide ms protein engineering. 🔗 https://t.co/J2plBpYRFZ #proteinengineering #bioinformatics

Missense mutations in intrinsically disordered regions can reshape protein structural ensembles—and their function. Learn how a single point mutation can shift the dynamic landscape of disordered proteins. 🔗

Where did proteins come from? This COSB review explores how short peptide “building blocks,” traced by bottom-up chemistry & protein space mining, illuminate the ancient origins and evolution of modern proteins. 🔗 https://t.co/mlpneqW8mp #proteinevolution #structuralbiology

Guest editors Yana Bromberg and Benjamin Schuler introduce article collection on Folding and Binding (2025), discussing Protein folding and binding with a little help from AI:

Molecular simulations are unlocking the physics of biomolecular condensates. Explore how coarse-grained and all-atom MD reveal atomistic and residue-level drivers of phase separation, charting the path ahead for simulating complex condensate systems. 🔗

From sequence to mechanism: Enzymology is being transformed by metagenomics, structural biology, and AI. This COSB perspective explores how disordered regions, mechanistic bioinformatics, and in silico catalysis are redefining our understanding of enzymes. https://t.co/NuMXdFXhc1

New COSB review unpacks cutting-edge tools to predict 3D structure & binding affinity in protein–DNA/RNA complexes—essential for understanding gene regulation & repair. 🔗 https://t.co/CH0oHonVec #bioinformatics #proteinDNA

From noisy data to molecular insights: simulation-based inference (SBI) is revolutionizing single-molecule experiments with Bayesian frameworks + deep learning. Explore how SBI bridges models and reality. 🔗 https://t.co/RBqxE7fKqO #SingleMolecule #MachineLearning

Missense protein variants shape disease outcomes, but mechanisms are elusive. This COSB review highlights structure-based ensemble frameworks linking amino acid substitutions to stability, interactions & regulation. 🔗 https://t.co/5ys1qKVrnT #genomics #precisionmedicine

Proteins are finely tuned machines—mutations far from the active site can shift dynamics and allostery. Learn how to design function via conformational landscapes. 🔗 https://t.co/5nihe6TLWm #proteinengineering #allostery #COSB

Amyloid aggregation is complex, and so are its intermediates. New insights into their heterogeneity could unlock therapies for neurodegenerative diseases. 🔗 https://t.co/bLBo6mXoKW #amyloids #neurodegeneration #COSB

Dynamic IDPs, complex binding modes, and AI tools like AlphaFold are shaping a new era in protein interaction studies. This COSB review explores it all. 🔗 https://t.co/ub2ukQjBzn #IDPs #AIinBiology #structuralbiology

Check out our latest article collection on Folding and Binding (2025), guest edited by Yana Bromberg and Benjamin Schuler!

From static snapshots to dynamic ensembles—advances in RNA modeling are bridging in vitro insights with cellular function, accelerating RNA biology and therapeutic discovery. #RNA #EnsembleModeling #StructuralBiology #COSB https://t.co/yaFXRoEDIa

Unlocking RNA dynamics with molecular rulers! Learn how EPR, FRET, and XSI—enabled by unnatural base pair labeling—are revealing the structure and flexibility of large RNAs like flavivirus genomes. #RNA #StructuralBiology #MolecularRulers #COSB https://t.co/T5Dkm05O2x