The Colombo Lab
@lab_colombo
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Giorgio Colombo's Computational Chemistry and Biology Lab; Always Room for Improvement; University of Pavia, Italy. @lab-colombo.bsky.social
The University of Pavia
Joined April 2020
In memory of Len Neckers, whose pioneering work on #HSP90 and #PTMs laid the foundation for how we think about chaperone regulation. Our latest @TrendsBiochem review builds on this legacy to explore the formation and function of #epichaperomes. https://t.co/m0ZwHqoGDy
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Online now! Design of multi-target peptide modulators for protein chaperone networks
cell.com
Torielli et al. describe a computational approach that allows the identification of peptide Cdk4-2 to dually inhibit the molecular chaperones Hsp70 and Hsp90. This multi-target inhibitor binds the...
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🚀New adventures in #DrugDiscovery: We designed multitarget leads that hit Hsp70, Hsp90 & Cdc37 at once—disrupting chaperone networks that fuel tumor growth. Collaboration with @MedMol, @GestwickiLab Labs #CancerResearch #CompChem @AIRC @Structure_CP
https://t.co/rDGqKFj4fa
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Impact of Genetic Variants Associated with Neurodevelopmental Disorders on the WAVE Regulatory Complex https://t.co/d5uAyqmKAL
@DeRubeisLab @lab_colombo
#JCIM Vol65 Issue14 #Letter
pubs.acs.org
The WAVE regulatory complex (WRC) is a heteropentamer necessary for the regulation of actin cytoskeleton. Genetic variants in components of the WRC have been associated with increased risk for...
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#descriptoroftheday #moleculardescriptors #qsar #cheminformatics #alvatips Intrinsic state pseudoconnectivity indices have been described in "Modeling with Molecular Pseudoconnectivity Descriptors. A Useful..." https://t.co/HEAIDt79jP Check #alvaDesc at: https://t.co/sqJE1r2XAR
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It takes two to tango! Here our latest two works exploring the roles of TRAP1 in tumor biology ! @arasola @dsb_unipd @LaviniaFerrone @FilomeniL @lab_colombo
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Exciting to share our latest work now out on RedoxBiology! A stimulating journey with @arasola @FilomeniL @lab_colombo @LaviniaFerrone @dsb_unipd Disulfide-mediated tetramerization of TRAP1 fosters its antioxidant an...
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Inhibition of sperm-egg interaction through a synthetic water soluble analogue of seminolipid. Towards the development of a non-hormonal contraceptive? Check it out! @LaStatale @LPanza61249 @lauramorelli5 #glycotime #glycochemistry #glycolipids
mdpi.com
Background/Objectives: Seminolipid (sulfogalactosylglycerolipid (SGG)) is abundantly present on the sperm surface and its roles in sperm–egg interaction are well-documented. SGG liposomes have direct...
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💡Featured by @MSKLibrary: Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation Our recent publication in @NatureComms - check it out! #Phosphorylation #Epichaperome #HSP90 #PrecisionMedicine
https://t.co/enqGwNx4Cr
nature.com
Nature Communications - Epichaperomes are chaperone assemblies that reorganize protein networks under stress. Here, authors reveal how HSP90 phosphorylation drives epichaperome formation, linking...
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See our latest paper in @NatureComms, by @LucaTorielli @FedericaGuarra Stefano Serapian @GestwickiLab. We show how pathogenic mutations disrupt dynamics, rewire allosteric routes and impair function in chaperone Hsp60. #CompChem #MolecularBiology
https://t.co/2v3mD0nFKu
nature.com
Nature Communications - Mutations cause impairment of function in the chaperone Hsp60. Here, the authors investigate their impact with MD simulations from the monomer to the 28-mer complex, and...
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How do stressors remodel #brain function before symptoms emerge? &network-centric intervention strategies as a promising avenue for disease-modifying #therapy in AD #Alzheimers #epichaperomes #neuroscience #SystemsBiology #networkbiology #drugdiscovery
researchsquare.com
Alzheimer’s disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we...
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Read our latest research with @arasola on how mutations on the mitochondrial protein TRAP1 impact its function and cancer related activities, published with @springernature on Cell Death and Disease in
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Happy to share our latest work "Large-scale energy decomposition for the analysis of protein stability". We use simple simulations to predict the impact of mutations on stability of more than 250 mutants in different folds. https://t.co/ozw2RVrcTG
#CompChem #CompBiol #AI #Biotech
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A friendship from childhood goes a long way - sometimes even to a paper in JACS😎I was fortunate to take part in this fantastic work of @TomSolomek and his team, combining their passion for strained compounds and photocages @UZH_Chemistry @HimsUva @snsf_ch
Cutting of fragile ferrocene with green light✂️ Very proud of the awesome team who made this work possible: Remek,@malincij,Simon and @PStacko💪🏻 Thanks to @HimsUva, @UZH_Chemistry,@ERC_Research,@snsf_ch Enjoy your reading👍🏻🙂 Picture by @PStacko🙌🏻
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My postdoc, Iris Guo, and I will offer an online course in February/March 2025, applied machine learning in chemistry. I will have five spots for students outside TU Berlin. Students from underrepresented groups will have priority. More info: https://t.co/xhxsPnrflH
#compchem
anunesalves.owlstown.net
My postdoc, Dr. Iris Guo, and I will offer an online course in February/March 2025, applied machine learning in chemistry. Classes: - online - from 02.17 to ...
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To be or not to be an oxidase? 🧪 Dive into our latest exploration of this classic enzymatic conundrum, now published in @ACScatalysis: 10.1021/acscatal.4c05944. Grateful for the fantastic collaboration with @lab_colombo, @dirktischler, and @fraaije1!
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Re-upping this ad for a #postdocposition in our lab 🧠 🧬🔬 RT appreciated 🙏
We are recruiting a postdoc! Have expertise in RNA biology and want to apply it to neuro and neurodev disorders? Then apply 👇🏼 📌 $73,588 💰 📌 access to postdoc housing 🏠 📌 Support for internationals 🌍 📌 Awesome view 😅 🙏 RT https://t.co/vt7vREDrSx
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This is what happens when you let computer scientists design molecules 🤯 Oral presentation @NeurIPSConf #NeurIPS2024
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Special Issue #ProteinNetworks by @lab_colombo Dr. Fuxreiter @UniPadova Dr. Emili @CNSB_OHSU Dr. Kastritis @3Dstructure @DinaSchneidman @cxarramirez @RichardDoveston Dr. Vlassakis @Rice_BIOE Dr. Nyarko @OregonState @CerdaLab Dr. Komives @UCSanDiego @ionpetr @chiosislabmskcc et al
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Design and Test of Molecules that Interfere with the Recognition Mechanisms between the SARS-CoV-2 Spike Protein and Its Host Cell Receptors https://t.co/QfCNLZRXjD
@Francesca3995 @Ionica_Masgras @cla_laq @lab_colombo @arasola @eli_moroni @UniPadova
#JCIM Vol64 Issue21 #compchem
pubs.acs.org
The disruptive impact of the COVID-19 pandemic has led the scientific community to undertake an unprecedented effort to characterize viral infection mechanisms. Among these, interactions between the...
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