Andy Truman PhD
@TrumanLab
Followers
6K
Following
88K
Media
345
Statuses
7K
Professor in Biological Sciences @unccharlotte Group leader, Charlotte Group for Proteostasis Research Interested in the role of Hsp70 PTMs (Chaperone Code)
Charlotte, NC
Joined December 2018
1/Excited to share our latest study "Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications" in @PLOSBiology: https://t.co/GGSHx6UWvm This work started with a simple idea-
journals.plos.org
Interactions between the molecular chaperone Hsp70 and its client proteins are critical for cellular viability and the response to stress. This proteomics study uses cross-linking mass spectrometry...
12
34
192
Didn’t think I could love @TwistBioscience more, but then they sent me a goodie bag of cool stuff for my 11 year old daughter 🔥🔥🔥
2
1
14
How well do you think you understand chaperones? In our recent @MolSystBiol paper, @fried_lab's Divya Yadav shows that obligate chaperone clients in cells are totally different from the proteins that "need" chaperones during in vitro refolding. https://t.co/EAeGVuDSld
embopress.org
imageimageStructural profiling of the E. coli proteome deficient in DnaKJ or trigger factor shows which proteins are chaperone-dependent in vivo, a surprising temperature effect on DnaKJ dependency,...
2
3
9
Great to see this work by our team, lead by PhD student Thomas Walker. We found that the heat shock protein HSPB5 is a powerful chaperone that prevents TDP-43 fibrillation AND maintains TDP-43 condensate fluidity even more than its sibling HSPB1.
Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP-43 low complexity domain https://t.co/2BjRUIb7SB
#biorxiv_biochem
0
1
2
What if proteins that can’t refold in vitro fold perfectly fine inside cells? Our new News & Views article in Molecular Systems Biology, written with Dr. @TrumanLab , explores this interesting insight from Yadav et al. (2025). For decades, chaperone-client relationships have
4
6
32
Now more than ever in this crazed era, read my memoir about how William F. Buckley, Jr., one of the foremost Catholics of the 20th century befriended me, a Jewish kid, when I was 19. We need more of this and to celebrate it. WFB was a giant and we miss him more than ever! @NRO
4
12
68
Fantastic review!
How can post-translational modifications rewrite cellular networks? Read https://t.co/wGytP54NTl
@SpringerNature @TrendsBiochem
#Epichaperome #PTMs #NetworkBiology #SystemsBiology #MolecularChaperones #CellBiology #Neurodegeneration #CancerResearch
0
0
9
Thrilled to spotlight the Charlotte Biology and Biotechnology Exchange Group at the NCBiotech Summit 2025 @unccharlotte
@ncbiotech
Shan Yan, Ph.D. @unccharlotte shares how the Charlotte Biology and Biotech exchange group has hosted 36 distinguished speaker since 2017. CBB plans to expand the community and collaborations for continued impact. #NCBiotechSummit2025
0
1
2
Great presentation!
Shan Yan, Ph.D. @unccharlotte shares how the Charlotte Biology and Biotech exchange group has hosted 36 distinguished speaker since 2017. CBB plans to expand the community and collaborations for continued impact. #NCBiotechSummit2025
0
0
6
Had a wonderful time visiting @MarquetteU Biological Sciences to share our recent work on the Hsp70 Chaperone Code! Such a beautiful campus and loved talking with the students and faculty about the exciting research going on 🔥🔥🔥#hsp70
0
0
9
Great work by @MeganMitchem1 @DuhitaMirikar Ashley Choi and @Rajlekha_061424 @unccharlotte @UNCCBiology
0
0
2
In this work we engineered a collection of 46 yeast strains that express mutations in the 23 known phosphorylation sites of Cdc37. Through phenotypic fingerprinting we have chaaracterized master regulators vs fine tuner sites of this essential co-chaperone!
1
0
1
Excited to share our new work "Dissecting the Cdc37 Co-chaperone Code: Functional Roles in Chaperone-Mediated Stress Adaptation" in press at the Journal of Biological Chemistry https://t.co/VRaayVKoX7 🔥🔥🔥
jbc.org
Cell division cycle 37 (Cdc37) is a kinase-specific cochaperone that scaffolds protein kinase clients to the heat shock 90 (Hsp90) chaperone system. Although phosphorylation at residues S14 and S17...
1
10
30
Fantastic review by @GabrielaChiosis and team connecting the epichaorome with the chaperone code
⭐️Very excited to share that our article 'PTMs as Molecular Encoders: Reprogramming Chaperones into Epichaperomes for Network Control in Disease' is out online now in @TrendsBiochem
#PTMs #HSP90 #epichaperome #PPI #neuroscience
https://t.co/pszZWjRGLb
0
9
19
Thank you Coach Devaney @KyleDevaney17 and UTEP Football for the Game day invite. Super Blessed for this opportunity. Go Miners!!!!! @MaranaFB @CoachSWUTEP @CoachBobbyDaly @MaranaAthletics
@CoachSteward__
9
6
16
UNC Charlotte's momentum has never been stronger. From research growth to community impact, 2024–25 was a defining year. Check out our annual report ⤵️ https://t.co/u9wIaytBNu
153
12
35
Congratulations @rwsobol !
The #EMGS is pleased to announce that Dr. Robert W. Sobol @rwsobol has been appointed the new Editor-in-Chief for Environmental and Molecular Mutagenesis. This September, congratulate our new Editor-in-Chief in-person at the 56th Annual Meeting of the EMGS in Rochester, New
0
0
3
Incredibly proud of superstar colleague @dan_gard ! Looking forward to reading the research that comes from these studies 🔥🔥🔥 @unccharlotte @UNCCBiology
I'm absolutely thrilled to share that I've received a Notice of Award for my $3.7 million R01 grant!
0
0
5
Wonderful work!
Just out in Journal of Biological Chemistry! Our latest paper uses deep learning to dissect PTM crosstalk on Hsp90 and its role in drug binding. Proud of this team effort!
0
0
4
Not finding ways to get your app into Claude & ChatGPT is like not putting your business "on the internet". I don't know how that ends for you. ChatGPT is opening this up with it's Apps SDK, so I spent time building out a Rails 8 app with it's own custom UI in ChatGPT. It's
jasonsich.com
Learn how to use the OpenAI Apps SDK within Rails to create your own ChatGPT App
1
0
8
Wonderful new paper from @MedMol and team using innovative AI modeling to understand the complex array of PTMs on Hsp90 🔥🔥🔥 https://t.co/6sexPynlQe
#chaperonecode #hsp90
0
0
1
Two thoughts- 1) if they are not funding at 5% what are they funding and 2) given scoring variation I think we are at the point that the top 25% go into a lottery with winners selected for funding
5 percentile grant, I was suggested to re-submit...which I will, I guess.
2
1
9
NIH will only accept six applications per PI per calendar year. https://t.co/Ao76WopQj4 via @drugmonkeyblog
drugmonkey.wordpress.com
NIH has issued NOT-OD-25-132 Supporting Fairness and Originality in NIH Research Applications which informs us that NIH will only accept six new, renewal, resubmission, or revision applications fro…
6
14
30
Excited to begin my new role as Associate Chair for Research in Biological Sciences at UNC Charlotte 🔥 @unccharlotte
18
10
210
Welcome to Cytronic a robot-powered 3PL. No errors. No sick days. Just precision. See how much your business can save on fulfillment costs today.
0
7
37