Have you checked out our latest @NatureComms article? Learn about how #phosphorylation can impact the conformation of the ubiquitous protein #HSP90 thus opening therapeutic avenues & drugging the undruggable #epichaperome #CancerResearch #PrecisionMedicine

@ChiosisLabMSKCC sushi dinner a few weeks ago! It is always so nice to gather as a lab for dinner - this time we were joined by a collaborator and friend, Hediye, and a couple of our summer interns! 🍣😋

RT @chiosislabmskcc: Heat Shock Protein 90 (#HSP90) is a cellular chaperone protein ubiquitously present in human body and is responsible f….

RT @chiosislabmskcc: 🧵Follow this thread by @Tanaya_rc to learn about the intriguing case of #HSP90 - adapted from our recent publication i….

To know more about this strange and intriguing case check out our work linked below (8/8) .#phosphorylation #epichaperome #cancer #conformation #cellstress.

In cancer, Casein Kinase 2 (CK2) interacts with #HSP90 and puts phosphate groups on Serine 255 and Serine 226 positions of the charged linker region of HSP90 thereby changing its structure or conformation. This dangerous alter ego of HSP90 helps the cancer cells to survive. (7).

This switch of HSP90 to "bad" and the formation of the epichaperome makes it so the #epichaperome now aids #cancer. (6).

#Cancer is a multifactorial disease that manifests as a result of chronic cellular stress, a trigger that turns HSP90 into Mr. Hyde. Mr. Hyde can now associate with other chaperone protein members and form a gang (high molecular weight assembly) called “#epichaperome”. (5).

In our latest work, now published in @NatureComms, we uncover how #HSP90 switches from “good” to “bad” in cancer. (4).

Heat Shock Protein 90 (#HSP90) is a cellular chaperone protein ubiquitously present in human body and is responsible for folding other important proteins in the cell. However, it can exist either as Dr. Jekyll or Mr. Hyde depending on how stressed the cells are. (3) #cellstress.

Any protein consists of strings of amino acids that fold into distinct different shapes and structures inside the cell depending on the cellular environment. (2).#proteinstructure #HSP90 #chaperone #cancer #chembio.

🧵Follow this thread by @Tanaya_rc to learn about the intriguing case of #HSP90 - adapted from our recent publication in @NatureComms (1/8). #cancer #phosphorylation #epichaperome #conformation #cellstress.

RT @chiosislabmskcc: 🧵Have you checked out our recent article in @COSB_CRSB? Follow along with this thread by @souparna_c to learn about th….

🚀 Integrating dfPPI with other omics could reveal comprehensive disease mechanisms, paving the way for groundbreaking discoveries and precision therapeutics across numerous diseases. #MultiOmics #FutureResearch #Omics #dfPPI #SystemsBiology #Bioinformatics (11/11).

🌐The open-access dfPPI Platform lets researchers worldwide visualize and analyze dfPPI data interactively, empowering researchers with access to cutting-edge proteomics analysis. #OpenScience #Proteomics (10).

⚕️dfPPI helps identify a hyperconnectivity state—an increased level of protein interactions in tumors, where cells become highly sensitive to therapies enhancing their effectiveness. #PrecisionMedicine #CancerTherapy (9)

🔗Protein connectivity changes detected by dfPPI show minimal correlation with overall protein expression—demonstrating the need to look beyond protein levels to understand true disease biology. #Proteomics #dfPPI #DiseaseBiology #ChemicalBiology (8)

🎗️In cancer cells, #dfPPI identifies dysfunctional PPIs critical for malignant behavior—offering insights into novel therapeutic vulnerabilities like mitotic network disruptions. #CancerResearch #Therapeutics #ProteinProteinInteractions #NovelTherapeutics (7)

🧠In Alzheimer’s research, dfPPI unveiled significant changes in protein connectivity, with extensive losses and gains of interactions, highlighting disrupted pathways crucial for memory. #Alzheimers #Neurodegeneration (6)

🖥️New #bioinformatics pipelines now make dfPPI data analytics user-friendly, aiding scientists to map disease-specific protein interactions and pathways without specialized training. #DataScience #Bioinformatics #ProteinInteraction (5).

🔍Specialized #ChemicalProbes are central to dfPPI, capturing dysfunctional interactions—trapping thousands of protein interactors, enabling precise identification of disease-driven interactome changes. #MassSpec #Proteomics (4)