Super excited to share our review in @NatureRevCancer with my co-authors @LisaButler5 and @shilpainthelab on tumor FA metab in treatment resistance and obesity. The full text can be viewed at https://t.co/PA9qNCMv6U @Sydney_Uni @syd_health @CPC_usyd @UniofAdelaide @OCDEM

Many thanks to the very helpful reviewers and editor, and the support from @Sydney_Uni Robinson Fellowship, @CPC_usyd , @syd_health and School of Medical Sciences.

Ultimately, we believe that there is significant potential for pathway-centric approaches to reveal new aspects of cellular metabolism from metabolomic data.

Finally, in silico analyses of loss-of-function and drug sensitivity screens showed that Cluster 4 cells were more susceptible to gene deletion and drug targeting of glutamine metabolism and OXPHOS than cells in Cluster 3.

Notably, Cluster 4 cells had high TCA cycle metabolites/pyr ratios, produced more lactate yet consumed less glucose and glutamine, & > OXPHOS activity compared to Cluster 3 cells with low TCA cycle metabolite ratios; explained by more glut cataplerotic efflux and not glycolysis.

We started by determining if cancer cells can be clustered into subtypes based on metabolic pathway activity. By calculating pathway-centric metabolite ratios, we identified 5 clusters that were not explained by media composition, tissue type or origin, or mutational status.

Incredibly proud of our latest publication in @MolSystBiol https://t.co/GPAE9wMvOS led by @Nancy_T_S in collab Jean Yang and Lake-Ee Quek. We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.

Thrilled to share our work from @HoyLipidLab @CPC_usyd @ausrotaryhealth in @MolSystBiol that shows cells of different tissue origins can be grouped by metabolic pathway ratios to identify common therapeutic vulnerabilities! https://t.co/l1TcHZsW4u

We have a postdoc position available in our team to undertake a UKRI-funded project to develop a new cultured skeletal muscle model for studying glc metabolism and insulin action. https://t.co/jnObCCq8vh @IMS_MRL Please RT. Please email if interested.

@OdedRechavi In the 90s (?), NIH started giving separate grades for technical advance and scientific excellence; the grant's overall score was the sum of both. Getting more scientific excellence is REALLY difficult. Technical advance is easy - buy a bigger, newer machine. Guess what happened?

@OdedRechavi The low hanging fruit is gone, thinking is hard and Nature publishing groups made clear that results are optional as long as you have 5+ colorful figures, 3+ people from Harvard, paid the $10k+ open access fee and the title is "Comprehensive multi-omics landscape of <X> in <Y>".

🚨The exodus of #MedTwitter #OncTwitter to #BlueSky @bluesky #OncSky is fascinating. All the #Twitter birds are now flying freely in the Bluesky. 🐦💙 Will #Bluesky succeed where #Threads and #Mastodon struggled? #MedTwitterMigration #BlueSkySocial @OncoAlert @tmprowell

Reading is one of the top 3 perks of the job but the first thing we postpone so we can complete other bureaucratic tasks

We are hiring! If you’re interested in how stem cell behavior is regulated by metabolism and you have mass spectrometry experience, this may be the postdoc position for you. Come join our international team in Brussels (link with application details in post below)! 🧫🔬🥼👩‍🔬👨🏽‍🔬

Some great grant news means my lab is hiring at the postdoc level for multiple positions! If you are broadly interested in cancer metabolism, check out our projects: https://t.co/wI5ptrsTVr.

Burnout isn't about hours worked. In fact, there are usually much deeper causes. Leaders should start to recognize when it's occurring, And take steps to help. Use this graphic to find causes of burnout in your organization.

Gonna get a tattoo on my chest that reads "just because a result is statistically significant does not mean it is biologically significant" & a matching tattoo on my back that reads "just because a result is biologically significant does not mean it is statistically significant"

🚨 TWITTER!! 🚨 Our Dept is recruiting junior faculty! Please RT and share in your circles 🙏🏼😊 This is a broad search in GI patho/physiology. But, pancreatic cancer researches, do take note! Contact @YatrikShahLab or @LyssiotisLab with questions 🤝

Leadership opportunities are often limited at institutes. Folks who remain in leadership positions for extended periods contribute to the scarcity. I urge scientists in leadership roles to consider creating co-leadership or assistant leadership roles for folks on the rise.

Save the date! The annual Cancer Metabolism Symposium @NYASciences will be April 8, 2025 @nyulangone featuring another great lineup of speakers @KivancBirsoy @Chiolaboratory @HaigisLab @IntlekoferLab @ThalesPapaG @RutterLab @DanWahlMD @EileenWhitePhD @ElaineFuchsLab