Lipid Metabolism Lab
@HoyLipidLab
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Located @cpc_usyd @Sydney_Uni with research interests in type 2 diabetes, cancer metabolism, obesity led by Dr Andrew Hoy
Sydney, New South Wales
Joined December 2016
Super excited to share our review in @NatureRevCancer with my co-authors @LisaButler5 and @shilpainthelab on tumor FA metab in treatment resistance and obesity. The full text can be viewed at @Sydney_Uni @syd_health @CPC_usyd @UniofAdelaide @OCDEM
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Many thanks to the very helpful reviewers and editor, and the support from @Sydney_Uni Robinson Fellowship, @CPC_usyd , @syd_health and School of Medical Sciences.
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Ultimately, we believe that there is significant potential for pathway-centric approaches to reveal new aspects of cellular metabolism from metabolomic data.
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Finally, in silico analyses of loss-of-function and drug sensitivity screens showed that Cluster 4 cells were more susceptible to gene deletion and drug targeting of glutamine metabolism and OXPHOS than cells in Cluster 3.
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Notably, Cluster 4 cells had high TCA cycle metabolites/pyr ratios, produced more lactate yet consumed less glucose and glutamine, & > OXPHOS activity compared to Cluster 3 cells with low TCA cycle metabolite ratios; explained by more glut cataplerotic efflux and not glycolysis.
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We started by determining if cancer cells can be clustered into subtypes based on metabolic pathway activity. By calculating pathway-centric metabolite ratios, we identified 5 clusters that were not explained by media composition, tissue type or origin, or mutational status.
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Incredibly proud of our latest publication in.@MolSystBiol led by @Nancy_T_S .in collab Jean Yang and Lake-Ee Quek. We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.
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RT @Nancy_T_S: Thrilled to share our work from @HoyLipidLab @CPC_usyd @ausrotaryhealth in @MolSystBiol that shows cells of different tissu….
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RT @DPhaz: We have a postdoc position available in our team to undertake a UKRI-funded project to develop a new cultured skeletal muscle mo….
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RT @robinsall: @OdedRechavi In the 90s (?), NIH started giving separate grades for technical advance and scientific excellence; the grant's….
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RT @AlexanderMWolf7: @OdedRechavi The low hanging fruit is gone, thinking is hard and Nature publishing groups made clear that results are….
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RT @VivekSubbiah: 🚨The exodus of #MedTwitter #OncTwitter to #BlueSky @bluesky #OncSky is fascinating. All the #Twitter birds are now flyi….
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RT @OdedRechavi: Reading is one of the top 3 perks of the job but the first thing we postpone so we can complete other bureaucratic tasks.
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RT @nickvangastel: We are hiring! If you’re interested in how stem cell behavior is regulated by metabolism and you have mass spectrometry….
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RT @airdlab: Some great grant news means my lab is hiring at the postdoc level for multiple positions! If you are broadly interested in can….
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RT @georgestern: Burnout isn't about hours worked. In fact, there are usually much deeper causes. Leaders should start to recognize when….
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RT @TanentzapfLab: Gonna get a tattoo on my chest that reads "just because a result is statistically significant does not mean it is biolog….
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RT @LyssiotisLab: 🚨 TWITTER!! 🚨 Our Dept is recruiting junior faculty! Please RT and share in your circles 🙏🏼😊. This is a broad search in….
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RT @CterminiPhD: Leadership opportunities are often limited at institutes. Folks who remain in leadership positions for extended periods co….
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RT @lydfinley: Save the date! The annual Cancer Metabolism Symposium @NYASciences will be April 8, 2025 @nyulangone featuring another grea….
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