Jinrong Hu
@HJRBio
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Postdoc at Hadjantonakis lab@MSK. PhD w/ Rong Li & @AlexanderBersh1 @MBIsg. Cell bio, development, cytoskeleton, cardiomyocyte. Views mine. @jinrong.bsky.social
New York, USA
Joined August 2013
Congrats Scott @asdScott0331 🎉exciting work manipulating anaphase chromosome movement with optogenetics! https://t.co/DN0R3cnC4f
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Nature research paper: GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling https://t.co/dJ7FVVlavU
nature.com
Nature - Heparan sulfate proteoglycans facilitate the assembly of clusters of glycoRNAs and cell surface RNA-binding proteins, which negatively modulate VEGF-A signalling and angiogenesis.
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Biomolecular condensates sustain pH gradients at equilibrium through charge neutralization:
nature.com
Nature Chemistry - pH is a critical regulator of (bio)chemical processes and therefore tightly regulated in nature. Now, proteins have been shown to possess the functionality to drive pH gradients...
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CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis: Cell
cell.com
CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that...
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Metabolically regulated proteasome supramolecular organization in situ: Cell
cell.com
Structural steps along the assembly of proteasome storage granules—membraneless organelles that form in response to metabolic shifts in yeast—are visualized inside cells by cryo-electron tomography....
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Our new paper on reassessing the heritability of human lifespan is out in @ScienceMagazine! 🧬 For decades, the consensus has been that genetics explains just 20–25% of lifespan differences. We found that after accounting for extrinsic mortality, that number jumps to ~50%. A 🧵
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Today in @NatMetabolism! 🖨️ A @dzhk_germany research team identify lamin A/C as a key regulator of cysteine catabolic flux essential for proper cell fate and longevity. 💡 Learn more: https://t.co/vyjELFZPW6
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Check out our paper @CellCellPress where we visualized the interplay between two key DNA replication factors PCNA & RFC and found an unexpected non-catalytic role of RFC in stabilizing PCNA’s interaction with DNA polymerase and enabling efficient synthesis
cell.com
The RFC clamp loader remains associated with PCNA beyond the loading step, supporting processive DNA replication by stabilizing the inherently unstable PCNA-polymerase ẟ complex.
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AlphaGenome is out in @nature today along with model weights! 🧬 📄 Paper: https://t.co/1fHzSPiY1x 💻 Weights: https://t.co/z6JWLT4Mpv Getting here wasn’t a straight path. We sat down @googledeepmind to discuss the story behind the model, paper & API: https://t.co/cT8CiXfnxQ
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Our paper is out today in Nature Physics! 🎉 https://t.co/cdDVIgtREc It was highlighted by Brown News: https://t.co/MTWpQJIs5Y Huge thanks to my amazing co-authors @hyuntae_jeong and @carles_falco, and deepest gratitude to my mentor @ianywonglab for leading this journey. 🧵
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Thrilled to see our work on land-ExM 🏜️published in @JCellBiol! It is a high signal, super-res approach that maps protein and lipid ultrastructure simultaneously, allowing us to see 3D interactions of organelles and phase separations like never before. 🔬#ExM #CellBiology
.@YinyinZhuang, @XiaoyuShi2 et al. @UCIrvine introduce land-ExM, a superresolution approach that simultaneously maps protein and #lipid ultrastructure to reveal 3D interactions of #membrane #organelles and condensates. https://t.co/UMyZSYePGW
#ExM #Microscopy #StructuralBiology
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Fantastic😍
DeepSpaceDB https://t.co/ElmSf9UOsT >2k #SpatialTranscriptomics Visium samples 👉Interactive, downloadable data analysis QC➡️ manual/LLM image annotation➡️ in-sample or cross-sample spot clustering BASS BayesSpace➡️ Spatially variable genes singleCellHaystack SPARK-X binSpect➡️
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Our CytoTape work is published today in @Nature! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. https://t.co/frFwoQeIRZ
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How STABLE is chromosomal INSTABILITY? We followed copy numbers over years in colorectal cancer patients. Chromosomal instability is high at single cell level, but does not manifest macroscopically, suggesting negative selection of karyotypes: https://t.co/Oef8YppVXT
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Cancer patients rarely get Alzheimer's. And a 15-year study in @Cell just explained why. They found a protein that clears brain plaques in mice - by activating the brain's own IMMUNE CELLS 🧵
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My friend threw me a funny paper updated on biorxiv yesterday, reminding me Nat. aging paper onlined this week on ESCRT III exporting chromatin fragment. The funny paper is on ESCRT III in nuclear envelop budding for transferring giant mRNA like titin😆 https://t.co/JpNRBBgkem
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Now online! MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids
cell.com
RNA-binding-mediated multimerization of MYC concentrates RNA-degrading factors around double-stranded RNAs and R-loops. This prevents aberrant RNAs from accumulating and leaking into the cytosol....
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pretty much like migrasome, is it?😆
Great story from the @NieswandtLab in @ScienceMagazine: uncovering a non-classical platelet mechanism that drives inflammation via integrin- and tetraspanin-rich tethers. A fresh angle on thrombo-inflammation. Happy to be part of this work!
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