Yinyin Zhuang
@YinyinZhuang
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PhD Candidate @UCIBioSci with @XiaoyuShi2, postgraduate @YaleCellBio with @WUMIN_LAB | Nuclear Lamina | Expansion Microscopy | Cell Membrane
Irvine, CA
Joined August 2018
Excited to share my first preprint in @XiaoyuShi2 lab! A 3D stack ExM image of cell is attached here to share you with my daily observation (magenta: whole lipid, cyan: whole protein). I believe every tiny structure has a story. And this time it is about the nuclear invagination.
Check out our surprising finding in nuclear invagination's function: regulating ribosome biogenesis. Nuclear tunnels = more ribosomes! I am proud of my talented student @YinyinZhuang, and inspiring collaborators @wtzhaolab, @ChrisEMiles, and @razorenovalab!
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RT @ShorterLab: Transcription factor condensates: Preventing aggregation by DNA binding: Cell
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RT @WUMIN_LAB: When Ca2+ oscillates, [Ca2+] is the variable. Is [Ca2+] also the control parameter that defines the system's stability?. Hap….
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RT @JCellBiol: Our new #Cancer Cell Biology collection comprises mechanisms underlying cancer cell invasion, including analyses of lipogene….
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RT @SergioCruzLeon1: Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬.w/ @jpkreysing, Johan….
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RT @ShorterLab: Overlapping nuclear import and export paths unveiled by two-colour MINFLUX:
nature.com
Nature - High spatiotemporal precision tracking using 3D MINFLUX shows that nuclear import and export occur in overlapping regions of the central pore, providing insight into transport across the...
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RT @WUMIN_LAB: What do action potential, hearing, calcium oscillations have in common? A periodic, synchronous opening of ion channels that….
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RT @JCellBiol: Cytoplasmic #ribosomes on #mitochondria alter the local membrane environment for protein import, say Ya-Ting Chang, Danielle….
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RT @LammerdingLab: Interested in nuclear #mechanobiology, and how advanced genomic tools can shed light on how the cell nucleus might sense….
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RT @MAG2ART: "Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties" and are made by multiple cell types.….
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RT @ShorterLab: Single-molecule live-cell RNA imaging with CRISPR–Csm:
nature.com
Nature Biotechnology - Single-molecule live-cell fluorescence in situ hybridization uses an RNA-targeting CRISPR–Csm complex to image and track endogenous RNAs.
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RT @naxerova: You are never too senior to work hard & get yourself a nice first author Science paper! 👏🏻👏🏻👏🏻.
science.org
Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)...
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RT @cppape: After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for int….
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RT @vnzloy: SAMCell: Generalized Label-Free Biological Cell Segmentation with Segment Anything.Alexandra Dunnum VandeLoo, Nathan J. Malta,….
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RT @MBIsg: Our heartfelt condolences to Linda and all affected by this devastating news. Prof Michael Sheetz was an inspirational Founding….
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Powerful tool for endogenous level live cell imaging! Pain of CRISPR KI bye bye👋.
Explore our tagging tools from the @Pelletierlab! They feature cassettes with mStayGold for bright and photostable endogenous fusions. Now available on @Addgene: Check out the paper in @embojournal: #FluorescenceFriday
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RT @biorxiv_cellbio: The dark side of fluorescent protein tagging: the impact ofprotein tags on biomolecular condensation .
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RT @arjunrajlab: Check out this amazing resource! High quality illustrations for free!.HT @LuciaScience.
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RT @ShorterLab: Disordered regions of human eIF4B orchestrate a dynamic self-association landscape:
nature.com
Nature Communications - This study reveals how the intrinsically disordered region of eIF4B governs its transition from monomers to oligomers and condensed droplets, providing key insights into how...
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