Graef Lab
@GraefLab
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We are interested in the #cell_biology of #autophagy, #mitochondria, and #ageing.
Cornell University (+ MPI-Age)
Joined January 2020
Excited to start this new adventure with fantastic colleagues! If you are interested in working on the molecular mechanisms of autophagy and cellular ageing, please contact me!.
Martin Graef (@GraefLab), new assistant professor in our Department of Molecular Biology and Genetics, joined CALS this spring to study how cells maintain their homeostasis and function under diverse stresses. Welcome Martin! @CornellMBG
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RT @TheHurleyLab: Proud of new work from the lab by Zhicheng (Chen) Cui @Chen3dem using single-particle cryo-EM on….
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RT @KraftLabFR: 🎉 We're thrilled to share that our former colleague, @_mariyalicheva, now with the @GraefLab, received the prestigious Hans….
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Congratulations, Costas! Such a beautiful paper.
📢 I am so incredibly happy and proud about this one!.🔟+ years in the making, 2,5 years since first submission, 1⃣ year since we posted it @biorxivpreprint, it finally found it’s home @NatureCellBio!. Open access 👇. Detailed 🧵down below ⏬
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RT @RagusaLab: Our work on the biochemical reconstitution of mitophagy initiation led by @Devika_An has been updated on bioRxiv. You can c….
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RT @weillinstitute: 🚨🚨Come join us! We’re searching for two assistant professor positions in cell and molecular biology, in collaboration w….
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RT @CornellMBG: Excited to announce an MBG faculty search for two assistant professor positions in collaboration with the Weill Institute f….
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RT @bealelab: We’ve worked out how the molecular machines that create acidic compartments can recruit autophagy (self-eating) machinery whe….
cell.com
Timimi et al. reveal that the targeting of de-acidified compartments with ATG8s is mediated by a direct interaction between the V-ATPase subunit V1H and ATG16L1. This interaction is important for...
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RT @osman_lab: 🚀Excited to share our latest paper, where we explore dynamic changes in mtDNA heteroplasmy in living cells! Discover how as….
embopress.org
imageimageThe basis for dynamic changes in mitochondria DNA variations in cell populations, known as heteroplasmy, remains unclear. Here, live-cell tracking of mtDNA variants in yeast populations...
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RT @langer_lab: Huge congrats to Sadig @SNiftullayev who has successfully defended his doctoral thesis🥳✨🍻!!! #PhDone @MPIAGE @CGA_age.
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RT @WollertLab: Eat less to live longer? #Autophagy degrades damaged or toxic cellular material to keep cells in good shape. We discovered….
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Beautiful work from the Lackner Lab as always!.
From MBoC.Temporal control of contact site formation reveals a relationship between mitochondrial division and Num1-mediated mitochondrial tethering. @LLLackner developed systems to control the formation and depletion of mitochondria-PM contact sites.
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RT @weillinstitute: 🚨The Weill Institute is hiring a new faculty member!🚨. Assistant Professor position is now open in @weillinstitute, joi….
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RT @AutophagyAarhus: We are happy to share the publication below, which sheds light on the role of Atg1, Atg11 and Atg13 in bulk autophagy….
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RT @MariaBohnert: I am thrilled to see our work on the #Vacuole #LipidDroplet #MembraneContactSite vCLIP published in @Dev_Cell! Fantastic….
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RT @Plusk4u: Dynamin-like proteins at the nuclear envelope? That and other surprises in excellent work by @PhilipMannino1 with help from @N….
biorxiv.org
Autophagic mechanisms that maintain nuclear envelope homeostasis are bulwarks to aging and disease. By leveraging 4D lattice light sheet microscopy and correlative light and electron tomography, we...
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RT @JakobsLab: The human prohibitin complex forms a bell-shaped structure in the inner mitochondrial membrane. Check out our #preprint toge….
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RT @ShoSuzuki20: I am super excited to share that my first corresponding author paper has been published in JCB (@JCellBiol). Surprising ro….
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RT @LazarouLab: Molecular simulations, biochemistry, and cell biology come together to reveal how a crucial step in autophagy is executed.….
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RT @mito911_: Congrats to Dr. Shanlin Rao @HummerLab et al. for revealing in high detail the gymnastic of the LC3 lipidation machinery as i….
science.org
Three distinct membrane-docking steps of the ATG12–ATG5-ATG16L1-ATG3–LC3 complex control LC3 lipidation at the phagophore.
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