Following the lead of @UniFreiburg , we’re officially saying goodbye to Twitter (X). Our account will be archived and no longer updated. See you on Bluesky! Find us at @kraftlabfr! #eXit.

RT @UniFreiburg: #UniFreiburg vollzieht #eXit aus X. Der Account bleibt als Archiv sichtbar, neue Tweets wird es nicht geben. Wir setzen au….

RT @CIBSS_UniFR: #CIBSS is leaving X, this account will be archived and no longer updated. Follow us on #Bluesky and find us there as @cibs….

Big thanks to Chunmei Chang and Yi Lu for their insightful "News and Views" article on our recent paper! We really appreciate the way they explained our findings. 📰 You can read it here: And thanks, @NatureCellBio , for highlighting our work!.

RT @sfb1177: 🔬 Excited to share the latest research findings of @sfb1177 members @KraftLabFR and @WilflingLab on the conditions required fo….

RT @UniFreiburg: Wie entsorgen Zellen Abfall? Forschende aus Freiburg @KraftLabFR @CIBSS_UniFR & Frankfurt @WilflingLab zeigen in @NatureCe….

📢 Check out the full paper here: And feel free to reach out for any questions or comments!.#Autophagy #PhaseSeparation #CellBiology.

🔑 In summary, we uncovered an unknown mechanism where Atg11/FIP200 phase separation drives initiation hubs formation for selective autophagy initiation in both yeast and mammals. Thanks to all collaborators & the first authors @_mariyalicheva, Jeremy, Riccardo, and @Hesktorplay.

4️⃣ In mammalian cells, FIP200 (Atg11 homolog) clusters on cargo surfaces—membrane-bound & membrane-less. These clusters connect the phagophore assembly site to the ER, essential for autophagy initiation.

3️⃣ Using a neo-cargo (μNS) in yeast, we showed that low-affinity binding to a common autophagy receptor triggers degradation. This opens pathways for targeting artificial cargoes via autophagy.

2️⃣ The scaffold protein Atg11 forms phase-separated clusters on cargo surfaces. These clusters act as platforms to recruit core machinery proteins like Atg1 and Atg9 by avidity, initiating autophagy.

1️⃣ We showed the importance of low-affinity interactions between autophagy receptors and cargoes for autophagy machinery assembly. Enhancing the affinity of the receptor-cargo interaction impairs selective autophagy by preventing receptor clustering and thus machinery assembly!.

🚨 Paper Alert! We’re starting off the year with our latest publication in @NatureCellBio on the role of phase separation in selective autophagy initiation! .This work was a close and exciting collaboration with @WilflingLab.🔗 .Here are the key findings👇

Congrats @WilflingFlorian !.

Big congrats to Dr. Christopher Eickhorst for successfully defending his thesis on the role of FIP200 in autophagy! 🎓 So grateful to have Chris as a colleague and to have shared countless moments of scientific discovery together. 🔬 #Autophagy #CellBiology #AcademicResearch

RT @CIBSS_UniFR: Just over 2 weeks left to apply! Our highly collaborative and interdisciplinary Cluster of Excellence is looking for a new….

RT @cell_club: Recruitment of autophagy initiator TAX1BP1 advances aggrephagy from cargo collection to sequestration | The EMBO Journal htt….

🎉 We're thrilled to share that our former colleague, @_mariyalicheva, now with the @GraefLab, received the prestigious Hans-Grisebach-Preis from @UniFreiburg for her dissertation! 🏅Congrats on this great achievement, Mariya!. Photo credit: Universität Freiburg / Jürgen Gocke

RT @CIBSS_UniFR: How do plants control their growth? .A team of researchers @UniFreiburg led by CIBSS member Thomas Laux identified the HAN….

RT @aland_lab: Condensates can not only bend biomembranes, but also cut them (fission). Check out the first evidence in our @nature paper:….