Kraft Lab
@KraftLabFR
Followers
218
Following
89
Media
13
Statuses
42
Research group led by Claudine Kraft at the @UniFreiburg. Our focus is on understanding the molecular mechanisms of #yeast and #mammalian #autophagy.
Albert-Ludwigs-Universität
Joined May 2023
Following the lead of @UniFreiburg , we’re officially saying goodbye to Twitter (X). Our account will be archived and no longer updated. See you on Bluesky! Find us at @kraftlabfr! #eXit
0
0
3
#UniFreiburg vollzieht #eXit aus X. Der Account bleibt als Archiv sichtbar, neue Tweets wird es nicht geben. Wir setzen auf dezentrale Kurznachrichtendienste: Folgen Sie uns auf #Mastodon ( https://t.co/2hyjZJ5KYV) & #Bluesky (@uni-freiburg.de)! Mehr dazu https://t.co/KV3Snf3jzJ
3
7
19
#CIBSS is leaving X, this account will be archived and no longer updated. Follow us on #Bluesky and find us there as @cibss.bsky.social! More info on the #eXit of @UniFreiburg:
0
3
6
Big thanks to Chunmei Chang and Yi Lu for their insightful "News and Views" article on our recent paper! We really appreciate the way they explained our findings. 📰 You can read it here: https://t.co/ARseoCrdDr And thanks, @NatureCellBio , for highlighting our work!
nature.com
Nature Cell Biology - The clearance of biomacromolecules through selective autophagy is crucial for cellular homeostasis. A study now identifies receptor mobility as a key factor influencing cargo...
0
0
7
🔬 Excited to share the latest research findings of @sfb1177 members @KraftLabFR and @WilflingLab on the conditions required for the initiation of #autophagy. 🤝 @CIBSS_UniFR @NatureCellBio
Our latest publication together with the @KraftLabFR, with a nice summary of the findings in this thread 🧵👇🏼
0
3
7
Wie entsorgen Zellen Abfall? Forschende aus Freiburg @KraftLabFR @CIBSS_UniFR & Frankfurt @WilflingLab zeigen in @NatureCellBio, wie schwache Molekül-Wechselwirkungen #Autophagie auslösen – ein möglicher Schlüssel für die Forschung zu #Alzheimer & #Krebs. https://t.co/J1xAtDOGuq
0
2
6
📢 Check out the full paper here: https://t.co/KLEgfgHAVu And feel free to reach out for any questions or comments! #Autophagy #PhaseSeparation #CellBiology
nature.com
Nature Cell Biology - Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein...
0
0
1
🔑 In summary, we uncovered an unknown mechanism where Atg11/FIP200 phase separation drives initiation hubs formation for selective autophagy initiation in both yeast and mammals. Thanks to all collaborators & the first authors @_mariyalicheva, Jeremy, Riccardo, and @Hesktorplay
1
0
2
4️⃣ In mammalian cells, FIP200 (Atg11 homolog) clusters on cargo surfaces—membrane-bound & membrane-less. These clusters connect the phagophore assembly site to the ER, essential for autophagy initiation.
1
0
0
3️⃣ Using a neo-cargo (μNS) in yeast, we showed that low-affinity binding to a common autophagy receptor triggers degradation. This opens pathways for targeting artificial cargoes via autophagy.
1
0
0
2️⃣ The scaffold protein Atg11 forms phase-separated clusters on cargo surfaces. These clusters act as platforms to recruit core machinery proteins like Atg1 and Atg9 by avidity, initiating autophagy.
1
0
0
1️⃣ We showed the importance of low-affinity interactions between autophagy receptors and cargoes for autophagy machinery assembly. Enhancing the affinity of the receptor-cargo interaction impairs selective autophagy by preventing receptor clustering and thus machinery assembly!
1
0
0
🚨 Paper Alert! We’re starting off the year with our latest publication in @NatureCellBio on the role of phase separation in selective autophagy initiation! This work was a close and exciting collaboration with @WilflingLab 🔗 https://t.co/KLEgfgHAVu Here are the key findings👇
2
26
101
Congrats @WilflingFlorian !
Congratulations to the @WilflingLab for this incredible achievement! @WilflingFlorian is now an EMBO Young Investigator! 🧪🧪 https://t.co/AkMPQI420G
@EMBO
1
2
6
Big congrats to Dr. Christopher Eickhorst for successfully defending his thesis on the role of FIP200 in autophagy! 🎓 So grateful to have Chris as a colleague and to have shared countless moments of scientific discovery together. 🔬 #Autophagy #CellBiology #AcademicResearch
0
1
14
Just over 2 weeks left to apply! Our highly collaborative and interdisciplinary Cluster of Excellence is looking for a new colleague with expertise in #cryoEM #structuralbiology and #signaling
#facultypositions #professorship
🚨 #JobAlert: W3 Professorship in Physical Chemistry with a focus on Cryo-Electron Microscopy. Join the Faculty of #Chemistry and #Pharmacy @UniFreiburg and contribute to cutting-edge research in the Cluster of Excellence #CIBSS. Apply by Nov 12, 2024! 👉
0
5
9
Recruitment of autophagy initiator TAX1BP1 advances aggrephagy from cargo collection to sequestration | The EMBO Journal
embopress.org
imageimageIn aggrephagy, cargo is collected in condensates prior to its sequestration; however, the transition between these two processes is unclear. This article shows that the recruitment of the...
1
6
23
🎉 We're thrilled to share that our former colleague, @_mariyalicheva, now with the @GraefLab, received the prestigious Hans-Grisebach-Preis from @UniFreiburg for her dissertation! 🏅Congrats on this great achievement, Mariya! Photo credit: Universität Freiburg / Jürgen Gocke
3
1
8
How do plants control their growth? A team of researchers @UniFreiburg led by CIBSS member Thomas Laux identified the HAN molecule as an important regulator of plant root growth in conjunction with WOX5. Published in @NaturePlants. 🌱 ➡️ https://t.co/u1bEWIriMN
0
7
16
Condensates can not only bend biomembranes, but also cut them (fission). Check out the first evidence in our @nature paper: https://t.co/ZUBpp3tKuJ Great collaboration between maths, physics and biology @AgudoCanalejo @XiaofengFangLab @KnorrLab @csbdresden
2
14
75