We have developed an entirely new mechanism of action for gene knockdown -> trafficking of targeted mRNAs to the lysosomal, using lysosomal trafficking oligonucleotides (LyTONs)!. Published in @ChemicalScience . Led by @disha_kashyap_, with @milnetom68 .

RT @disha_kashyap_: We’ve integrated DNA nanotech into targeted protein degradation! . Our oligoPROTACs act like small mol PROTACs but can….

RT @disha_kashyap_: We have engineered lysosomal trafficking-ASOs (LyTONs)! Novel mechanism of gene knockdown🧬 . LyTONs don’t need RNase H….

New preprint 🎇 We developed oligonucleotide PROTACs (OligoPROTACs), which show comparable activity to small molecule equivalents - but can be *switched off*, using DNA nanotech, to restore protein levels!. Last of @disha_kashyap_'s trilogy!.@milnetom68.

🚨 Preprint alert 🚨 We have developed an entirely new mechanism of action for ASO gene knockdown -> lysosomal trafficking 🧬! . Works with non-DNA ASOs (unlike RNase H mech) and higher activity than corresponding gapmers!. Led by @disha_kashyap_ @UCLChemistry @OxfordChemistry.

Massive congratulations to @DrZoeWaller for winning the 2024 @RoySocChem Chemical Biology and Bioorganic Lectureship - today, giving her fantastic award lecture at the 2025 RSC CBBG Forum, in Bristol 🥳🏆

RT @guido_bolognesi: Still time to apply for this #PhD project to join my group and @DrMikeBooth group at @UCLChemistry. Project is part of….

RT @disha_kashyap_: Read our review on next-generation covalent modifications for nucleic acid therapeutics! 🧬💊.

One of the (hopefully) useful things we did as part of this review is put together a table of all the currently approved short oligo therapeutics, their target/mechanism of action, and their CHEMISTRIES! We didn't manage to find anything out there like this!

We just published a review in ACS Bio & Med Chem Au on the state-of-the-art and future of covalent nucleic acid conjugates as therapeutics 🧬💊!. Led by @disha_kashyap_ .@ACSBioMed @ACS_DivBioChem.@UCLChemistry @OxfordChemistry @chem_in_cells

RT @disha_kashyap_: #ASO nuclear localisation unlocked via (+)-JQ1 conjugation! We’ve enhanced the splice switching activity and RNase H-re….

RT @KentsisResearch: JQ1 4EVA! @jaybradner @JunQiLab.

RT @wgibson: Fascinating work showing that the covalent addition of a nuclear importing compound, JQ1, to therapeutic oligonucleotides enha….

RT @YiliangDing: Super congratulations! 👍👍👍.

RT @ZutaoYu: Really cool design: sending ASO to nucleus via conjugating JQ1.

RT @guido_bolognesi: #Phd project available to join my group and @DrMikeBooth's group at @UCLChemistry on the #CDT in #Engineering Solutio….

We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer!. Preprint led by @disha_kashyap_ .@milnetom68 @chem_in_cells @OxfordChemistry @UCLChemistry

Excited to be at @BiochemSoc Synthetic Biology UK 2024 #SBUK24 at the Sanger Institute near Cambridge! Going to give a little talk about our magnetic activation work 😊 will be posting on the bluer place. #biochemevent

The annual @RSC_CBBG Forum is being held in Bristol next February!. This is fantastic opportunity for new group leaders and postdocs in #chembio to talk about their science - oral abstract deadline is 6th December!!!.

RT @KCGOrtiz: "Actually the term 'doctor' was originally used for doctoral degree holders and was co-opted by the medical field".