New book out: Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults ☛

US Senate: Pass the Mikaela Naylon Give Kids a Chance Act! Viewers: Please repost. @LeaderJohnThune @SenSchumer @BernieSanders @PattyMurray @SenatorBaldwin @ChrisMurphyCT @timkaine @SenatorHassan @Hickenlooper @SenMarkey @AlsoBrooksforMD @SenLBR @SenatorAndyKim @SenCassidy

SENATE: PASS THE MIKAELA NAYLON GIVE KIDS A CHANCE ACT NOW! "The thought of making it to the end of the day isn't in the cards for me right now. I'm still taking chemo in hopes that it will kill this thing, but it keeps taking everything away from me. I am 16. I have dreams

An inspirational example of 𝐬𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐜𝐫𝐞𝐚𝐭𝐢𝐯𝐢𝐭𝐲, 𝐨𝐫𝐢𝐠𝐢𝐧𝐚𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐫𝐢𝐠𝐨𝐫: Chemiosmosis remains one of the most striking examples of originality in modern biology. At a time when biochemical dogma insisted on high-energy intermediates, Peter

🚨The FDA approved durvalumab in combination with a chemotherapy regimen before & after surgery for people with early stage #gastriccancer and gastroesophageal #cancers. Congrats to @YJanjigianMD, who led the trial that resulted the approval! Learn more: https://t.co/09Zc6DTr4e

Wow! Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma | Science Advances

The @FDA has granted full approval to the targeted immunotherapy drug tarlatamab (Imdelltra®) for treating adults with advanced small cell #lungcancer (#SCLC) that that has spread after platinum-based chemotherapy. The approval was based on an international phase 3 clinical

1/ Excited to share our newest study in Nat Med on a vaccine targeting the recurrent fusion DNAJ-PKAc in #fibrolamellar carcinoma (FLC), a rare liver cancer affecting kids & young adults Full paper: https://t.co/ZjKtNEcAup @PGTimmune & @marinabaretti & @FibroFoundation

Preprints are much older than I thought. "In 1961, the [NIH] began to circulate biological preprints in a forgotten experiment called the Information Exchange Groups {IEGs)." A precursor to bioRxiv, the IEG apparently had more than 3,600 people on its mailing list and sent out

After leukemia treatments failed, Alyssa Tapley, at age 13, was told she would die. Then, doctors tried an experimental gene-edited therapy. She became the first human to try the treatment made possible by U.S. federal funding. Now 16, she’s cancer-free and planning her future.

Read and use the published “Modular Platform for Therapeutic Drug Delivery Using Trifunctional Bio-Orthogonal Macromolecular Conjugates”

“Housekeeping” proteins are cell type specific, eg different for neurons versus lymphocytes etc. This is why we include a variety of cytosolic, nuclear and other proteins as reference normalization standards in https://t.co/eO4BF89Fqu Quantitative Cell Proteomic Atlas

Tonight’s episode of @60Minutes will include a segment on the impact of federally funded science and recent cuts to science funding. Our lab’s development of base editing and prime editing and their clinical applications will be among the work described in the episode.

Where do cancers start? In the liver, not all cells are the same. The liver is divided into 3 “zones,” and each specializes in different metabolic tasks. We show in @Science that where a mutation occurs in a liver lobule can determine a cell’s fate. https://t.co/3YTc77gZcd (1/9)

Excited to launch an openRxiv partnership with the scientist-run AI review service qed science, the brainchild of @OdedRechavi https://t.co/QOhJIsoDj9 1/n

Our latest paper has just been published in Cell! https://t.co/5iAl1EaGEJ We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

Important PSA! The ASH Scientific Workshop website is experiencing a technical problem; YES, the Myeloid Workshop is on and should be on the website. Excellent speaker lineup ahead, stay tuned! Friday, Dec 5, 3-7 ET! 🫵🐔🐔🐔🫵

Disparate leukemia mutations converge on nuclear phase-separated condensates: Cell

Together with @mito_oncogene, today we report in Nature Genetics a peculiar + exciting discovery: positive selection of mutations to mitochondrial ribosomal RNA in cancer. Led by Sonia Boscenco, Jacqueline Tait-Mulder, and Minsoo Kim

Congratulations to this year’s recipients of the Memorial Sloan Kettering Cancer Center (MSK) 2025 Paul Marks Prize for Cancer Research: Dr. @AbdelWahablab, of @MSKCancerCenter; Dr. Andrea Ablasser, of @EPFL_en; and Dr. @cncurtis, of @StanfordMed. The prize, named in honor of

🚨Thrilled to share our latest work, published online today @Nature in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort @MSKCancerCenter led by superstars @VarunNarendraMD + @das_tandrila 🧵1/ https://t.co/0ubLHCbR9I